Patents by Inventor Clayton H. Johnson

Clayton H. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • chitin synthase sequences and their use for detection of and histoplasmosis
    Patent number: 7217519
    Abstract: The present invention describes Histoplasmosis capsulatum chitin synthase nucleic acid and protein sequences as reagents for the detection of H. capsulatum infection. Specifically, the invention describes intron sequences from the H. capsulatum chitin synthase gene which can be used for hybridization-based and PCR-based detection of H. capsulatum infection. In another embodiment, assays for H. capsulatum chitin synthase 2 polypeptide and/or mRNA used as a diagnostic test for H. capsulatum infection and/or histoplasmosis. Also described is the differentiation of H. capsulatum from Blastomyces dermititidis based on detection of intron 1 sequences specific to H. capsulatum chitin synthase 2. The present invention also comprises the production of H. capsulatum strains lacking functional chitin synthase 2 as a means to produce H. capsulatum having reduced pathogenicity.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: May 15, 2007
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Clayton H. Johnson, Joan E. McEwen
  • catalase sequences and their use in the detection of and histoplasmosis
    Patent number: 7052837
    Abstract: The present invention describes Histoplasmosis capsulatum catalase A and catalase P nucleic acid and protein sequences as reagents for the detection of H. capsulatum infection. Specifically, the invention describes intron sequences from the H. capsulatum catalase A (CATA) and catalase P (CATP) genes which can be used for hybridization and PCR based detection of H. capsulatum infection. In another embodiment, assays for H. capsulatum catalase P or catalase A polypeptides are used as diagnostic tests for H. capsulatum infection and histoplasmosis, respectively. Also described is the differentiation of H. capsulatum from Blastomyces dermititidis based on a H. capsulatum catalase P PCR based assay.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: May 30, 2006
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Clayton H. Johnson, J. Lyndal York, Joan E. McEwen
  • Histoplasma capsulatum catalase sequences and their use in the detection of Histoplasma capsulatum and Histoplasmosis
    Publication number: 20030082569
    Abstract: The present invention describes Histoplasmosis capsulatum catalase A and catalase P nucleic acid and protein sequences as reagents for the detection of H. capsulatum infection. Specifically, the invention describes intron sequences from the H. capsulatum catalase A (CATA) and catalase P (CATP) genes which can be used for hybridization and PCR based detection of H. capsulatum infection. In another embodiment, assays for H. capsulatum catalase P or catalase A polypeptides are used as diagnostic tests for H. capsulatum infection and histoplasmosis, respectively. Also described is the differentiation of H. capsulatum from Blastomyces dermititidis based on a H. capsulatum catalase P PCR based assay.
    Type: Application
    Filed: March 13, 2002
    Publication date: May 1, 2003
    Inventors: Clayton H. Johnson, J. Lyndal York, Joan E. McEwen