Abstract: The present disclosure provides methods of treating acute myeloid leukemia (AML) and methods of determining responsiveness to AML treatment regimens, including regimens comprising the administration of a BCL-2 inhibitor, a hypomethylating agent, a CD70-targeting agent, or any combination thereof, the methods comprising identifying the presence or absence of one or more biomarkers described herein.

Abstract: The present disclosure relates to compositions and methods for reducing cancer stem cells. In some aspects, the compositions and methods can comprise at least one metabolism modulating agent. In other aspects, the compositions and methods can comprise at least two metabolism modulating agents.

Abstract: Compositions and methods for reducing cancer stem cells and/or treating cancer are provided. In some aspects, the compositions and methods can comprise at least one metabolism modulating agent. In other aspects, the compositions and methods can comprise at least two metabolism modulating agents.

Abstract: Provided are an antibody or antigen binding fragment thereof that binds to CD70 for use in treating a myeloid malignancy in a human subject, who is resistant to BCL-2 inhibitor treatment and methods of treating a myeloid malignancy in a subject, said method comprising (a) selecting a human subject having a myeloid malignancy that has a reduced sensitivity or is refractory to a BCL-2 inhibitor; and (b) administering to the subject an antibody or antigen binding fragment thereof that binds to CD70. In certain embodiments, the myeloid malignancy is acute myeloid leukemia (AML). In certain embodiments, the antibody that binds to CD70 is cusatuzumab. In certain embodiments, a BCL-2 inhibitor is co-administered with the antibody or antigen binding fragment thereof that binds to CD70. In certain embodiments, the BCL-2 inhibitor is venetoclax.

Abstract: The present disclosure provides methods of treating venetoclax-resistant acute myeloid leukemia, including methods of identifying alternative treatment targets in specific subsets of patients who would otherwise be resistant to treatment with venetoclax and/or azacitidine.

Abstract: A fluid design with enhanced proppant-carrying capacity utilizes a low-viscosity fluid with high proppant carrying capacity and low required power for injection into a hydrocarbon-bearing, subterranean formation. A preferred viscosifying agent that comprises a copolymer polymerized from an acrylic acid monomer and a monomer selected from: a) at least one carboxylic acid monomer; b) at least one C1 to C5 alkyl ester and/or at least one C1 to C5 hydroxyalkyl ester of acrylic acid or methacrylic acid; c) one crosslinking monomer; and optionally d) at least one ?,?-ethylenically unsaturated monomer, may be used to produce a fracturing fluid that has the pumpability of a slick water fluid and the proppant-carrying ability of a cross-linked gel. An optimization process to optimize hydraulic fracture design evaluates and quantifies the proppant-carrying capacity of the invented fluid and its impact in the proppant transport during fracturing.

Abstract: The present disclosure relates to methods of identifying AML patients who will be resistant to venetoclax therapy and methods of treating venetoclax-resistant patients with myeloid leukemia cell differentiation protein (MCL-1) inhibitors.

Abstract: The present disclosure relates to compositions and methods for reducing cancer stem cells. In some aspects, the compositions and methods can comprise at least one metabolism modulating agent. In other aspects, the compositions and methods can comprise at least two metabolism modulating agents.

Abstract: An inflatable antenna may include an inflatable sock, an antenna, and an attachment port. The inflatable sock may have an inflated state and a deflated state, where the inflatable sock assumes an elongated inflated shape in the inflated state. The antenna may extend along the length of the inflatable sock. The attachment port may be configured for operable connection to an inflation mechanism.

Abstract: A fluid design with enhanced proppant-carrying capacity utilizes a low-viscosity fluid with high proppant carrying capacity and low required power for injection into a hydrocarbon-bearing, subterranean formation. A preferred viscosifying agent that comprises a copolymer polymerized from an acrylic acid monomer and a monomer selected from: a) at least one carboxylic acid monomer; b) at least one C1 to C5 alkyl ester and/or at least one C1 to C5 hydroxyalkyl ester of acrylic acid or methacrylic acid; c) one crosslinking monomer; and optionally d) at least one ?,?-ethylenically unsaturated monomer, may be used to produce a fracturing fluid that has the pumpability of a slick water fluid and the proppant-carrying ability of a cross-linked gel. An optimization process to optimize hydraulic fracture design evaluates and quantifies the proppant-carrying capacity of the invented fluid and its impact in the proppant transport during fracturing.

Abstract: Inflatable antenna assemblies are provided, including an inflatable container having an inflated state and a deflated state, the inflatable container having an interior surface and an exterior surface, a flexible antenna extending along the interior surface or the exterior surface of the inflatable container, such that the antenna deploys to an operable, extended configuration upon inflation of the inflatable container to the inflated state, and a port configured for operable connection to an inflation mechanism to inflate the container to the inflated state. Safety device structures, such as life rafts, life preservers, life jackets, buoys, and emergency beacons, having inflatable antenna portions, are also provided.

Abstract: A fluid design with enhanced proppant-carrying capacity utilizes a low-viscosity fluid with high proppant carrying capacity and low required power for injection into a hydrocarbon-bearing, subterranean formation. A preferred viscosifying agent that comprises a copolymer polymerized from an acrylic acid monomer and a monomer selected from: a) at least one carboxylic acid monomer; b) at least one C1 to C5 alkyl ester and/or at least one C1 to C5 hydroxyalkyl ester of acrylic acid or methacrylic acid; c) one crosslinking monomer; and optionally d) at least one ?,?-ethylenically unsaturated monomer, may be used to produce a fracturing fluid that has the pumpability of a slick water fluid and the proppant-carrying ability of a cross-linked gel. An optimization process to optimize hydraulic fracture design evaluates and quantifies the proppant-carrying capacity of the invented fluid and its impact in the proppant transport during fracturing.

Abstract: An internal combustion engine is coupled to an electric power generator. An exhaust manifold for the engine includes an exhaust gas conduit. A housing includes a catalyst in fluid communication with the conduit to receive exhaust produced by the engine. The catalyst is operable to reduce one or more constituents of the exhaust.

Abstract: Anti-accretion additives utilize silicone chemistry to prevent bituminous and heavy oil materials from sticking to metals surfaces such as drill bits, drillstring, casing and the like. Organopolysiloxanes and/or copolymers thereof are added directly to an aqueous drilling fluid or are first diluted in a solvent for adding to the drilling fluid. Further, an alkyl polyalkylene oxide may also be added. If a silicone oil is used as the solvent, the anti-accretion additive has the increased functionality of minimizing the amount of bituminous or heavy oil material which is retained in the drilling fluid when returned to surface and permits removal of the bituminous or heavy oil materials with the solids using conventional solids control equipment.

Abstract: Compositions for chemically removing sulfur deposits from reservoir formations, production tubing, flow lines, and other production equipment due to the production of sour gas and/or oil including reaction products of diamines and aldehydes at a mole ratio between about 1:1 and about 1:6, and methods for making and using same.

Abstract: An internal combustion engine is coupled to an electric power generator. An exhaust manifold for the engine includes an exhaust gas conduit. A housing includes a catalyst in fluid communication with the conduit to receive exhaust produced by the engine. The catalyst is operable to reduce one or more constituents of the exhaust.

Abstract: An internal combustion engine is coupled to an electric power generator. An exhaust manifold for the engine includes an exhaust gas conduit. A housing includes a catalyst in fluid communication with the conduit to receive exhaust produced by the engine. The catalyst is operable to reduce one or more constituents of the exhaust.

Abstract: An internal combustion engine is coupled to an electric power generator. An exhaust manifold for the engine includes an exhaust gas conduit. A housing includes a catalyst in fluid communication with the conduit to receive exhaust produced by the engine. The catalyst is operable to reduce one or more constituents of the exhaust.

Abstract: Compositions for chemically removing sulfur deposits from reservoir formations, production tubing, flow lines, and other production equipment due to the production of sour gas and/or oil including reaction products of diamines and aldehydes at a mole ratio between about 1:1 and about 1:6, and methods for making and using same.

Abstract: A substantially liquid gellant formed as one or more reaction products of a metal carboxylate or metal carboxylate amine salt, one or more organic acids, an ester which drives the reaction so that the reaction products are asymmetrical in structure, and a rheology modifier which preferentially interacts between the reaction products for prevent solidifying of the gellant reaction products until such time as the gellant is mixed with the fracturing fluid containing an activator after which the reaction products preferentially interact with the activator to gel the fracturing fluid. The resulting gellant is capable of gelling a hydrocarbon base fluid in less than about 30 seconds.