Abstract: The present invention relates to devices and methods for selectively removing contaminants from a crude product mixture. In an embodiment, the invention includes a method for removing free organic acids from a crude product mixture including contacting the crude product mixture with a metal oxide substrate, the metal oxide substrate having properties sufficient to bond with free organic acids in the crude product mixture, thereby removing free organic acids and forming a refined product mixture, and separating the refined product mixture from the metal oxide substrate. In an embodiment, the invention includes a device for removal of free organic acids from a crude product mixture including a first housing defining an interior volume, an input port, and an output port, and metal oxide media disposed within the first housing, the metal oxide media comprising a metal oxide selected from the group consisting of zirconia, alumina, hafnia, and titania. Other embodiments are also described herein.

Abstract: The present invention relates to methods and compositions for reducing L-pipecolic acid concentrations and/or effects in animals. In an embodiment, the invention includes a method of reducing plasma concentrations of L-pipecolic acid in animals including administering an effective amount of a composition including saponins. In an embodiment, the invention includes a method of reducing anorectic effects of L-pipecolic acid in animals including administering an effective amount of a composition including saponins. Other embodiments are also included herein.

Abstract: The present invention describes the use of porous metal oxides for the preparative purification of antibodies and biomolecules within a range of particle physical characteristics. Typically, particles from 15 to 100 microns in average diameter with pores sizes ranging from 400 to 600 angstroms and surface areas from 10 to 50 square meters per gram, and pore volumes from 0.1 to 0.4 mL/gram can be used for purification processes. The metal oxide particles that fall within this range of physical properties show enhanced utility and greater chromatographic capacity for antibodies than materials oxide particles falling outside of this range. Metal oxides such as zirconia, titania and alumina can all be modified with a multi-Lewis base moiety such as an organophosphate ethylenediamine-N,N-tetra(methylenephosphonic) acid (EDTPA), to produce a bio-compatible purification media for, biomolecules.

Abstract: The present disclosure is generally directed to systems and methods for applying liquid feed additives to a feed composition. In one embodiment, the system has a spray housing defining a spray chamber located adjacent a mix housing carrying a material composition. The mix housing defines a mix chamber, which contains an actuating device, such as an auger, that moves the material stream through the mix chamber. The mix chamber and spray chamber are in fluid communication. A spray nozzle is coupled to the spray housing and in fluid communication with an air source and liquid additive tank. The spray nozzle sprays a fog of air and liquid additive through the spray chamber and into the mix chamber, which gets deposited on the passing feed stream.

Abstract: The present invention relates to compositions comprising surface modified carbon-clad metal oxide membranes and monoliths. In particular the invention relates to membranes and/or monoliths comprising carbon-clad metal oxide, functionalized with an organic functional group. This organic functional group, either a small molecule or a polymer, can be chosen for specific end-uses, such as selective protein binding, ion exchange, hydrophobic interaction, chiral selection to enhance separations technology.

Abstract: The present invention describes the use of porous metal oxides for the preparative purification of antibodies and biomolecules within a range of particle physical characteristics. Typically, particles from 15 to 100 microns in average diameter with pores sizes ranging from 400 to 600 angstroms and surface areas from 10 to 50 square meters per gram, and pore volumes from 0.1 to 0.4 mL/gram can be used for purification processes. The metal oxide particles that fall within this range of physical properties show enhanced utility and greater chromatographic capacity for antibodies than materials oxide particles falling outside of this range. Metal oxides such as zirconia, titania and alumina can all be modified with a multi-Lewis base moiety such as an organophosphate ethylenediamine-N,N-tetra(methylenephosphonic) acid (EDTPA), to produce a bio-compatible purification media for, biomolecules.

Abstract: Metal oxide microspheres, particularly zirconia microspheres, produced by a method of hydrolysis of metal alkoxides in alcohol solutions in the presence of an organic acid or salt thereof with washing step or addition of a surfactant.

Abstract: Separation devices and systems are described which have a stationary phase and a mobile phase, wherein the stationary phase contains carbon-clad zirconium dioxide particles having attached at least one organic group. The stationary phase which is used in the present invention has the ability to dial in the selectivity by attaching the proper organic groups onto the carbon-clad zirconium dioxide particles in order to achieve the desired separation. Various separation processes are described such as chromatography, electrophoresis, magnetic separations, membrane separations, and the like. The processes to accomplish these types of separations are also described.

Abstract: A method and apparatus for controlling the addition of a liquid to a continuous flow of material. An algorithm is described for controlling the hydration process within a computerized grain delivery system. The grain delivery system operates by adding moisture to grain moving through the system, testing the moisture level of the hydrated grain and controlling the rate of flow of the wetting agent as a function of the wet grain moisture reading. In addition, a method is described for determining the relationship between dry grain moisture level, hydration level and the expected wet grain moisture level reading. Finally, a communications link is described which connects the grain delivery system to a remote computer.