Patents by Inventor Cleber Trujillo

Cleber Trujillo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPIES FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH ABNORMAL EXPRESSION OF CDKL5 GENE
    Publication number: 20240122939
    Abstract: The disclosure provides methods for rescuing defects caused by abnormal CDKL5 expression in a subject in need thereof, comprising administering to the subject therapeutically effective amount(s) of a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, a muscarinic receptor inhibitor, a GSK3 inhibitor, a Notch inhibitor and any combination thereof. The disclosure further provides methods for screening candidate drug candidates in a tiered series of assays and models (neurons, CDKL5-mosaic neurospheres, and cortical organoids).
    Type: Application
    Filed: February 25, 2022
    Publication date: April 18, 2024
    Inventors: Alysson R. Muotri, Cleber Trujillo
  • Functional cortical organoids, methods of making, and uses thereof
    Patent number: 11821895
    Abstract: The disclosure provides methods of making functional cortical organoids from somatic cells and stem cells and methods of using the functional organoids.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: November 21, 2023
    Assignee: The Regents of the University of California
    Inventors: Alysson Renato Muotri, Priscilla Davidson Negraes, Cleber Trujillo, Pinar Mesci
  • FUNCTIONAL CORTICAL ORGANOIDS, METHODS OF MAKING, AND USES THEREOF
    Publication number: 20200348287
    Abstract: The disclosure provides methods of making functional cortical organoids from somatic cells and stem cells and methods of using the functional organoids.
    Type: Application
    Filed: July 26, 2018
    Publication date: November 5, 2020
    Inventors: Alysson Renato Muotri, Priscilla Davidson Negraes, Cleber Trujillo, Pinar Mesci