Patents by Inventor Clemencia Pinilla

Clemencia Pinilla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective small molecule peptidomimetic melanocortin ligands
    Patent number: 11932628
    Abstract: The invention provides compounds having the general formula I: and salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Grant
    Filed: January 3, 2022
    Date of Patent: March 19, 2024
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Carrie Haskell-Luevano, Skye Ross Doering, Marcello A. Giulianotti, Clemencia Pinilla, Radleigh G. Santos, Richard A. Houghten
  • MELANOCORTIN LIGANDS AND METHODS OF USE THEREOF
    Publication number: 20240002438
    Abstract: Certain embodiments of the invention provide a compound of formula (I) or a compound of formula (II): R1—A1—A2—A3—A4—N(R2)2 ??(I) R3—A5—A6—A7—A8—N(R4)2 ??(II) or a salt thereof, wherein R1, R2, R3, R4, A1, A2, A3, A4, A5, A6, A7, and A8 are as defined herein, as well as methods of use thereof.
    Type: Application
    Filed: September 14, 2022
    Publication date: January 4, 2024
    Inventors: Carrie Haskell-Luevano, Mark David Ericson, Richard A. Houghten, Clemencia Pinilla, Marcello Angelo Giulianotti, Radleigh G. Santos
  • SELECTIVE SMALL MOLECULE PEPTIDOMIMETIC MELANOCORTIN LIGANDS
    Publication number: 20220213068
    Abstract: The invention provides compounds having the general formula I: and salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Application
    Filed: January 3, 2022
    Publication date: July 7, 2022
    Inventors: Carrie Haskell-Luevano, Skye Ross Doering, Marcello A. Giulianotti, Clemencia Pinilla, Radleigh G. Santos, Richard A. Houghten
  • Melanocortin ligands and methods of use thereof
    Patent number: 10899793
    Abstract: Certain embodiments of the invention provide a compound of formula (I): R1—C(?O)—W—X—Y—Z—N(R2)2??(I) or a salt thereof, wherein R1, R2, W, X, Y and Z are as defined herein, as well as methods of use thereof.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: January 26, 2021
    Assignees: Regents of the University of Minnesota, Torrey Pines Institute for Molecular Studies
    Inventors: Carrie Haskell-Luevano, Skye Ross Doering, Jon R. Appel, Marc A. Giulianotti, Richard A. Houghten, Clemencia Pinilla, Radleigh G. Santos
  • High-affinity small molecule formylpeptide receptor ligands from screening of combinatorial mixture-based libraries
    Patent number: 10048272
    Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution. The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: August 14, 2018
    Assignees: STC.UNM, Torrey Pines Institute for Molecular Studies
    Inventors: Bruce S. Edwards, Larry A. Sklar, Clemencia Pinilla, Richard A. Houghten, Jon R. Appel, Marc A. Giulianotti, Jose Medina-Franco
  • MELANOCORTIN LIGANDS AND METHODS OF USE THEREOF
    Publication number: 20170342107
    Abstract: Certain embodiments of the invention provide a compound of formula (I): R1—C(?O)—W—X—Y—Z—N(R2)2 ??(I) or a salt thereof, wherein R1, R2, W, X, Y and Z are as defined herein, as well as methods of use thereof.
    Type: Application
    Filed: May 25, 2017
    Publication date: November 30, 2017
    Inventors: Carrie Haskell-Luevano, Skye Ross Doering, Jon R. Appel, Marc A. Giulianotti, Richard A. Houghten, Clemencia Pinilla, Radleigh G. Santos
  • HIGH-AFFINITY SMALL MOLECULE FORMYLPEPTIDE RECEPTOR LIGANDS FROM SCREENING OF COMBINATORIAL MIXTURE-BASED LIBRARIES
    Publication number: 20160320402
    Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution. The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
    Type: Application
    Filed: February 2, 2016
    Publication date: November 3, 2016
    Inventors: Bruce S. Edwards, Larry A. Sklar, Clemencia Pinilla, Richard A. Houghten, Jon R. Appel, Marc A. Giulianotti, Jose Medina-Franco
  • High-affinity small molecule formylpeptide receptor ligands from screening of combinatorial mixture-based libraries
    Patent number: 9310364
    Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution. The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: April 12, 2016
    Assignees: STC.UNM, TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
    Inventors: Bruce S. Edwards, Larry A. Sklar, Clemencia Pinilla, Richard A. Houghten, Jon R. Appel, Marc A. Giulianotti, Jose Medina-Franco
  • CANCER VACCINES AND VACCINATION METHODS
    Publication number: 20120156232
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Application
    Filed: December 15, 2011
    Publication date: June 21, 2012
    Inventors: John S. Yu, Gentao Liu, Keith L. Black, Clemencia Pinilla
  • Conjugates of membrane translocating agents and pharmaceutically active agents
    Patent number: 8017727
    Abstract: Membrane translocation peptides, compositions comprising them, chimeric molecules comprising them, and methods of using them to achieve transmembrane transport of various agents.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: September 13, 2011
    Assignee: Merrion Research III Limited
    Inventors: Daniel O'Mahony, Imelda Lambkin, Clemencia Pinilla, Richard Houghten
  • METHODS AND COMPOSITIONS FOR DEREPRESSION OF IAP-INHIBITED CASPASE
    Publication number: 20110183358
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Application
    Filed: March 17, 2006
    Publication date: July 28, 2011
    Applicants: THE BURNHAM INSTITUTE, TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
    Inventors: John C. Reed, Richard A. Houghten, Adel Nefzi, John M. Ostresh, Kate Welsh, Clemencia Pinilla
  • CONJUGATES OF MEMBRANE TRANSLOCATING AGENTS AND PHARMACEUTICALLY ACTIVE AGENTS
    Publication number: 20100168381
    Abstract: Membrane translocation peptides, compositions comprising them, chimeric molecules comprising them, and methods of using them to achieve transmembrane transport of various agents.
    Type: Application
    Filed: December 23, 2009
    Publication date: July 1, 2010
    Inventors: Daniel O'Mahony, Imelda Lambkin, Clemencia Pinilla, Richard Houghten
  • Conjugates of membrane translocating agents and pharmaceutically active agents
    Patent number: 7638599
    Abstract: Membrane translocation peptides, compositions comprising them, chimeric molecules comprising them, and methods of using them to achieve transmembrane transport of various agents.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: December 29, 2009
    Assignee: Merrion Research III Limited
    Inventors: Daniel O'Mahony, Imelda Lambkin, Clemencia Pinilla, Richard Houghten
  • Peptide mixtures with immunomodulatory activity
    Publication number: 20090214580
    Abstract: The present invention is related to complex peptide mixtures with immunomodulatory effects and methods for their use. The invention is further directed toward treatments of diseases through the modulation of the immune system with complex peptide mixtures. The invention is also directed to methods for improving the characteristics of complex peptide mixtures.
    Type: Application
    Filed: February 2, 2005
    Publication date: August 27, 2009
    Inventors: Richard A. Houghten, Clemencia Pinilla, Roland Martin, Claus-Steffen Sturzebecher, Jacquline Shukaiak-Quant, Henry F. McFarland
  • Methods and compositions for derepression of IAP-inhibited caspase
    Publication number: 20090043099
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Application
    Filed: October 31, 2007
    Publication date: February 12, 2009
    Applicant: The Burnham Institute
    Inventors: John C. Reed, Richard A. Houghten, Adel Nefzi, John M. Ostresh, Clemencia Pinilla, Kate Welsh
  • CANCER VACCINES AND VACCINATION METHODS
    Publication number: 20080311142
    Abstract: Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
    Type: Application
    Filed: September 28, 2007
    Publication date: December 18, 2008
    Inventors: John S. Yu, Gentao Liu, Keith L. Black, Clemencia Pinilla
  • Methods and compositions for derepression of IAP-inhibited caspase
    Patent number: 7217688
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: May 15, 2007
    Assignees: The Burnham Institute, Torrey Pines Institute for Molecular Studies
    Inventors: John C. Reed, Richard A. Houghten, Adel Nefzi, John M. Ostresh, Clemencia Pinilla, Kate Welsh
  • Isolated, ssx-2 and ssx-2 related peptides useful as hla binders and ctl epitopes, and uses thereof
    Publication number: 20070105779
    Abstract: The invention related to peptides which bind to HLA molecules and are reactive with T cells that also react with complexes of HLA-A2 molecules and the peptide of SEQ ID NO: 17. Various uses of the peptides are disclosed.
    Type: Application
    Filed: July 23, 2003
    Publication date: May 10, 2007
    Inventors: Danila Valmori, Maha Ayyoub, Clemencia Pinilla
  • Pharmaceutical formulations and ligands for use therein; mimetics for UEA-1
    Patent number: 7166296
    Abstract: UEA-1 Mimetics, pharmaceutical formulations comprising them, and their uses as targeting agents for therapeutic and diagnostic purposes.
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: January 23, 2007
    Assignee: Sarlan, Ltd.
    Inventors: Richard Houghten, Clemencia Pinilla, Imelda Lambkin, Daniel O'Mahony, Christa Hamashin, Amy Schink, Lisa Osthues-Spindler
  • Methods and compositions for derepression of IAP-inhibited caspase
    Publication number: 20070003535
    Abstract: The invention provides isolated agents having novel chemical structures and possessing superior activity as derepressors of IAP inhibited caspase. The invention further provides a method of derepressing an IAP-inhibited caspase. The invention further provides assay methods employing labeled compounds of the invention, especially fluorescent labeled compounds.
    Type: Application
    Filed: March 17, 2005
    Publication date: January 4, 2007
    Inventors: John Reed, Richard Houghten, Adel Nefzi, John Ostresh, Clemencia Pinilla, Kate Welsh