Patents by Inventor Clemens A. van Blitterswijk

Clemens A. van Blitterswijk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6733503
    Abstract: The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. The invention further relates to a medical implant coated in said method and to a device for use in said method.
    Type: Grant
    Filed: January 9, 2001
    Date of Patent: May 11, 2004
    Assignee: IsoTis N.V.
    Inventors: Pierre Jean François Layrolle, Klaas de Groot, Joost Dick de Bruijn, Clemens A. van Blitterswijk, Yuan Huipin
  • Patent number: 6511510
    Abstract: The invention relates to an osteoinductive biomaterial, which is based on a ceramic material and which has a total porosity of 20 to 90%, wherein macropores are present having a size ranging from 0.1 to 1.5 mm, and wherein micropores are present having a size ranging from 0.05 to 20 &mgr;m. The invention further relates to a process for preparing said osteoinductive biomaterial.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: January 28, 2003
    Assignee: IsoTis N.V.
    Inventors: Joost D. de Bruijn, Klaas de Groot, Clemens A. van Blitterswijk, Yuan Huipin
  • Publication number: 20020095213
    Abstract: A prosthetic device formed from a polymer which, when contacted with a calcium salt, calcium is deposited on or in the polymer. The polymer includes a soft component and a hard component. The device has bone-bonding properties. The soft component provides for the deposition of calcium on or in the soft component and preferably is a polyalkylene glycol, and the hard component preferably is a polyester. A preferred material is a polyethylene glycol/polybutylene terephthalate copolymer.
    Type: Application
    Filed: July 12, 1993
    Publication date: July 18, 2002
    Inventors: DIRKJAN BAKKER, JOHANNES J. GROTE, CLEMENS A. VAN BLITTERSWIJK
  • Publication number: 20010053406
    Abstract: The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. The invention further relates to a medical implant coated in said method and to a device for use in said method.
    Type: Application
    Filed: January 9, 2001
    Publication date: December 20, 2001
    Applicant: IsoTis B.V.
    Inventors: Pierre Jean Francois Layrolle, Klaas de Groot, Joost Dick de Bruijn, Clemens A. van Blitterswijk, Yuan Huipin
  • Publication number: 20010051832
    Abstract: A prosthetic device formed from a polymer which, when contacted with a calcium salt, calcium is deposited on or in the polymer. The polymer includes a soft component and a hard component. The device has bone-bonding properties. The soft component provides for the deposition of calcium on or in the soft component and preferably is a polyalkylene glycol, and the hard component preferably is a polyester. A preferred material is a polyethylene glycol/polybutylene terephthalate copolymer.
    Type: Application
    Filed: February 16, 1995
    Publication date: December 13, 2001
    Inventors: DIRKJAN BAKKER, JOHANNES J. GROTE, CLEMENS A. VAN BLITTERSWIJK
  • Publication number: 20010008649
    Abstract: The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. The invention further relates to a medical implant coated in said method and to a device for use in said method.
    Type: Application
    Filed: January 9, 2001
    Publication date: July 19, 2001
    Applicant: Iso Tis B.V.
    Inventors: Pierre Jean Francois Layrolle, Klaas de Groot, Joost Dick de Bruijn, Clemens A. van Blitterswijk, Yuan Huipin
  • Patent number: 6207218
    Abstract: The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. The invention further relates to a medical implant coated in said method and to a device for use in said method.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: March 27, 2001
    Assignee: IsoTis B.V.
    Inventors: Pierre Jean François Layrolle, Klaas de Groot, Joost Dick de Bruijn, Clemens A. van Blitterswijk, Yuan Huipin
  • Patent number: 5508036
    Abstract: A device for preventing adhesions or binding of tissue to tissue or of tissue to bone which comprises a composite of a first layer and a second layer, each of which comprises a biodegradable polymer. The first layer is selected from the group consisting of a non-porous layer and a porous layer having a pore size no greater than 3.mu.. The second layer has pores which have a pore size of from about 30.mu. to about 250.mu.. Such a composite device provides for tissue growth into the second layer, while the first layer acts as an adhesion-preventing barrier, and enables attachment of the device to tissue without suturing. Alternatively, the device comprises the first layer hereinabove mentioned and a second layer which is an adherence layer and which adheres to tissue and/or bone.
    Type: Grant
    Filed: June 21, 1993
    Date of Patent: April 16, 1996
    Assignee: Osteotech, Inc.
    Inventors: Dirkjan Bakker, Erica A. Bakkum, Clemens A. van Blitterswijk