Patents by Inventor Clemens Antoni Van Blitterswijk
Clemens Antoni Van Blitterswijk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10961303Abstract: The present invention relates to a VHH which binds to a growth factor or is an antagonist for a growth factor, or binds to an implant.Type: GrantFiled: April 1, 2016Date of Patent: March 30, 2021Assignee: UNIVERSITEIT TWENTEInventors: Hermanus Bernardus Johannes Karperien, Cornelis Theodorus Verrips, Mohamed El Khattabi, Emilie Dooms Rodrigues, Jan De Boer, Clemens Antoni Van Blitterswijk, Renee De Bruin
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Patent number: 10933163Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.Type: GrantFiled: January 31, 2019Date of Patent: March 2, 2021Assignees: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit MaastrichtInventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
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Publication number: 20190167845Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.Type: ApplicationFiled: January 31, 2019Publication date: June 6, 2019Applicants: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit MaastrichtInventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
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Patent number: 10232081Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.Type: GrantFiled: June 16, 2015Date of Patent: March 19, 2019Assignees: Academisch Ziekenhuis Leiden, Xeltis B.V., Universiteit MaastrichtInventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
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Patent number: 9822336Abstract: A method for making an at least double layered cell aggregate and/or an artificial blastocyst, and/or a further-developed blastoid termed blastoid, by forming a double layered cell aggregate from at least one trophoblast cell and at least one pluripotent and/or totipotent cell, and culturing the aggregate to obtain an artificial blastocyst having a trophectoderm-like tissue that surrounds a blastocoel and an inner cell mass-like tissue. The cell aggregate can be formed from toti- or pluripotent stem cell types, or induced pluripotent stem cell types, in combination with trophoblast stem cells. Formation of a blastoid can be achieved by culturing the cell aggregate in a medium preferably comprising one or more of a Rho/ROCK inhibitor, a Wnt pathway modulator, a PKA pathway modulator, a PKC pathway modulator, a MAPK pathway modulator, a STAT pathway modulator, an Akt pathway modulator, a Tgf pathway modulator and a Hippo pathway modulator.Type: GrantFiled: April 16, 2014Date of Patent: November 21, 2017Assignees: UNIVERSITEIT MAASTRICHT, KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPENInventors: Nicolas Clément Rivron, Clemens Antoni Van Blitterswijk, Niels Geijsen, Erik Jacob Vrij
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Publication number: 20170128623Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.Type: ApplicationFiled: June 16, 2015Publication date: May 11, 2017Inventors: Joris Ivo Rotmans, Tonia Caroline Rothuizen, Lorenzo Moroni, Clemens Antoni Van Blitterswijk, Febriyani Fiain Rochel Damanik, Tom Lavrijsen, Martijn Antonius Johannes Cox, Antonius Johannes Rabelink
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Publication number: 20160355582Abstract: The present invention relates to a VHH which binds to a growth factor or is an antagonist for a growth factor, or binds to an implant.Type: ApplicationFiled: April 1, 2016Publication date: December 8, 2016Applicant: UNIVERSITEIT TWENTEInventors: Hermanus Bernardus Johannes KARPERIEN, Cornelis Theodorus VERRIPS, Mohamed EL KHATTABI, Emilie DOOMS RODRIGUES, Jan DE BOER, Clemens Antoni VAN BLITTERSWIJK, Renee DE BRUIN
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Publication number: 20160257926Abstract: The disclosure relates to a new approach to constructing cellular aggregates in vitro and their use in methods for producing 3D-tissue constructs in a modular way. In particular, the disclosure is directed to a method for in vitro producing a tissue construct comprising: a) combining living cells to form supracellular aggregates using spatial confinement; b) combining two or more of the supracellular aggregates in a mold or on a biomaterial; c) applying conditions that induce self-assembly within the combined supracellular aggregates to obtain the tissue construct; and d) applying conditions that induce tissue morphogenesis in the tissue construct.Type: ApplicationFiled: March 8, 2016Publication date: September 8, 2016Inventors: Nicolas Clément Rivron, Jeroen Rouwkema, Roman Truckenmuller, Séverine Le Gac, Clemens Antoni Van Blitterswijk, Erik Jacob Vrij
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Patent number: 9422524Abstract: The invention is directed to a treatment of diabetes, a scaffold and a method of preparing a scaffold. In a first aspect, this object is met by providing a scaffold comprising beta cell aggregates, wherein the aggregates are distributed over the scaffold in a predetermined pattern.Type: GrantFiled: August 17, 2010Date of Patent: August 23, 2016Assignees: UNIVERSITEIT TWENTE, ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMCInventors: Aart Alexander Van Apeldoorn, Hermanus Bernardus Johannes Karperien, Clemens Antoni Van Blitterswijk, Eelco Johan Paul De Koning, Marten Alexander Engelse
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Patent number: 9340605Abstract: The present invention relates to a VHH which binds to a growth factor or is an antagonist for a growth factor, or binds to an implant.Type: GrantFiled: October 21, 2010Date of Patent: May 17, 2016Assignee: UNIVERSITEIT TWENTEInventors: Hermanus Bernardus Johannes Karperien, Cornelis Theodorus Verrips, Mohamed El Khattabi, Emilie Dooms Rodrigues, Jan De Boer, Clemens Antoni Van Blitterswijk, Renee De Bruin
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Patent number: 9303245Abstract: The invention relates to a new approach to constructing cellular aggregates in vitro and their use in methods for producing 3D-tissue constructs in a modular way. In particular, the invention is directed to a method for in vitro producing a tissue construct comprising: a) combining living cells to form supracellular aggregates using spatial confinement; b) combining two or more of the supracellular aggregates in a mold or on a biomaterial; c) applying conditions that induce self-assembly within the combined supracellular aggregates to obtain the tissue construct; and d) applying conditions that induce tissue morphogenesis in the tissue construct.Type: GrantFiled: June 22, 2009Date of Patent: April 5, 2016Assignee: Universiteit MaastrichtInventors: Nicolas Clément Rivron, Jeroen Rouwkema, Roman Truckenmuller, Séverine Le Gac, Clemens Antoni Van Blitterswijk, Erik Jacob Vrij
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Publication number: 20160060593Abstract: The invention relates to a method for making an at least double layered cell aggregate and/or an artificial blastocyst, and/or a further-developed blastoid termed blastoid, by forming a double layered cell aggregate from at least one trophoblast cell and at least one pluripotent and/or totipotent cell, and culturing said aggregate to obtain an artificial blastocyst. This artificial blastocyst has a trophectoderm-like tissue that surrounds a blastocoel and an inner cell mass-like tissue. The cell aggregate can be formed from toti- or pluripotent stem cell types, or induced pluripotent stem cell types, in combination with trophoblast stem cells. Formation of a blastoid can be achieved by culturing the cell aggregate in a medium preferably comprising one or more of a Rho/ROCK inhibitor, a Wnt pathway modulator, a PKA pathway modulator, a PKC pathway modulator, a MAPK pathway modulator, a STAT pathway modulator, an Akt pathway modulator, a Tgf pathway modulator and a Hippo pathway modulator.Type: ApplicationFiled: April 16, 2014Publication date: March 3, 2016Inventors: Nicolas Clément Rivron, Clemens Antoni Van Blitterswijk, Niels Geijsen, Erik Jacob Vrij
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Patent number: 9133429Abstract: The invention relates to a multiwell system, characterized that said multiwell system having at least 3 wells, wherein said wells have a volume between 0.125 and 4.0 mm3.Type: GrantFiled: July 6, 2011Date of Patent: September 15, 2015Assignee: UNIVERSITEIT TWENTEInventors: Gustavo Andres Higuera, Lorenzo Moroni, Clemens Antoni van Blitterswijk
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Publication number: 20130174287Abstract: The invention relates to a multiwell system, characterized that said multiwell system having at least 3 wells, wherein said wells have a volume between 0.125 and 4.0 mm3.Type: ApplicationFiled: July 6, 2011Publication date: July 4, 2013Applicant: UNIVERSITEIT TWENTEInventors: Gustavo Andres Higuera, Lorenzo Moroni, Clemens Antoni van Blitterswijk
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Publication number: 20120276103Abstract: The present invention relates to a VHH which binds to a growth factor or is an antagonist for a growth factor, or binds to an implant.Type: ApplicationFiled: October 21, 2010Publication date: November 1, 2012Applicants: Universiteit Utrecht Holding B.V., University of TwenteInventors: Hermanus Bernardus Johannes Karperien, Cornelis Theodorus Verrips, Mohamed El Khattabi, Emilie Dooms Rodrigues, Jan De Boer, Clemens Antoni Van Blitterswijk, Renee De Bruin
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Publication number: 20120251587Abstract: The invention is directed to a treatment of diabetes, a scaffold and a method of preparing a scaffold. In a first aspect, this object is met by providing a scaffold comprising beta cell aggregates, wherein the aggregates are distributed over the scaffold in a predetermined pattern.Type: ApplicationFiled: August 17, 2010Publication date: October 4, 2012Applicants: Academisch Ziekenhuis Leiden H.O.D.N. LUMC, Universiteit TwenteInventors: Aart Alexander Van Apeldoorn, Hermanus Bernardus Johannes Karperien, Clemens Antoni Van Blitterswijk, Eelco Johan Paul De Koning, Marten Alexander Engelse
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Publication number: 20110009282Abstract: The invention is directed to a high throughput screening method for analyzing and interaction between a surface of a material and an environment. The screening method of the invention comprises: providing a micro-array comprising said material and having a multitude of units at least part of which have different topography; contacting at least part of said multitude of units with said environment; and screening said micro-array for an interaction between one or more of said units and said environment.Type: ApplicationFiled: October 31, 2008Publication date: January 13, 2011Inventors: Jan de Boer, Clemens Antoni Van Blitterswijk, Hemant Vijaykumar Unadkat, Dimitrios Stamatialis, Berendien Jacoba Papenburg, Matthias Wessling
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Publication number: 20040171045Abstract: The invention relates to a method of determining in vitro the capacity of a cell population to induce bone formation in vivo comprising the steps of: a) providing a sample of a cell population; b) dividing said sample into a first and a second part containing an equal number of cells; c) culturing the first part in the presence of an osteogenic stimulation factor; d) culturing the second part in the absence of an osteogenic stimulation factor; e) determining degrees of expression of a bone-specific protein; and f) comparing the degrees of expression of the bone-specific protein of the first part and the second part thereby providing a measure for the capacity of the bone cell population to induce bone formation in vivo.Type: ApplicationFiled: December 8, 2003Publication date: September 2, 2004Applicant: IsoTis N.V.Inventors: Joost Dick de Bruijn, Sandra Claudia da Silva Madureira Mendes, Clemens Antoni van Blitterswijk
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Patent number: 6737073Abstract: A biodegradable, biocompatible porous matrix as a scaffold for tissue engineering cartilage is formed of a copolymer of a polyalkylene glycol and an aromatic polyester such as a polyethylene glycol/polybutylene terephtalate copolymer. A ceramic coating such as a calcium phosphate coating may be provided on the scaffold by soaking the scaffold in a solution containing calcium and phosphate ions. A composite scaffold which may be used as an implant is preferably a two-layer system may be formed having an outer surface of a layer of the porous matrix formed of the copolymer, and an outer surface of a layer of a ceramic material. The composite scaffold may be prepared by casting the copolymer on top of the ceramic material in a mould. Cells are preferably seeded on the scaffold prior to implanting, and the scaffold may contain bioactive agents that are released on degradation of the scaffold in vivo.Type: GrantFiled: September 5, 2001Date of Patent: May 18, 2004Assignee: IsoTis N.V.Inventors: Tahir Mahmood, Jens Uwe Riesle, Clemens Antoni van Blitterswijk
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Publication number: 20040086544Abstract: The invention relates to a process for loading a polymer with one or more bioactive agents, using a wet spinning technique. The invention further relates to a polymer loaded with one or more bioactive agents, obtainable by said process and to the use thereof as a carrier for controlled drug release or as scaffold for tissue engineering.Type: ApplicationFiled: October 28, 2003Publication date: May 6, 2004Applicant: Chienna B.V.Inventors: Jeroen Mattijs Bezemer, Clemens Antoni van Blitterswijk, Jan Feijen, Dirk Wybe Grijpma