Patents by Inventor Clemens R. Muller-Reible

Clemens R. Muller-Reible has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vitamin K epoxide recycling polypeptide VKORC1, a therapeutic target of coumarin and their derivatives
    Patent number: 7939250
    Abstract: The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: May 10, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Johannes Oldenburg, Clemens R. Müller-Reible, Andreas Fregin, Simone Rost, Tim-Matthias Strom
  • Vitamin K Epoxide Recycling Polypeptide VKORC1, a Therapeutic Target of Coumarin and Their Derivatives
    Publication number: 20090094708
    Abstract: The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying coumarin derivatives, and also claims VKORC1 polypeptides and VKORC1 nucleic acids containing a sequence abnormality associated with a VKORC1 associated deficiency such as warfarin resistance, wherein the VKORC1 polypeptides and VKORC1 nucleic acids can be used for diagnosing these deficiencies. Moreover, the invention relates to methods for identifying coumarin derivatives usable in pest control of rodents.
    Type: Application
    Filed: September 5, 2008
    Publication date: April 9, 2009
    Applicants: Baxter International Inc., Baxter Heathcare Corporation
    Inventors: Johannes Oldenburg, Clemens R. Muller-Reible, Andreas Fregin, Simone Rost, Tim-Matthias Strom