Patents by Inventor Clemens Rufer
Clemens Rufer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4645762Abstract: Diphosphonic acid derivatives of the formula ##STR1## wherein X is cyano, 2-cyanoethyl, or 3- aminopropyl and Y is H, or X and Y together represent dimethylaminomethylene ((CH.sub.3).sub.2 NCH.dbd.), andR is hydrogen, alkyl of 1-4 carbon atoms, or a cation derived from a base, especially an alkali metal atom,excluding the cyanomethanebis (phosphonic acid diethyl ester),are pharmacologically active compounds.Type: GrantFiled: July 5, 1983Date of Patent: February 24, 1987Assignee: Schering AktiengesellschaftInventors: Helmut Biere, Clemens Rufer, Irmgard Boettcher
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Patent number: 4555406Abstract: An indanyl derivative of the formula ##STR1## wherein R.sub.1 and R.sub.2 are identical or different, and each is hydrogen, fluorine or chlorineR.sub.3 is hydrogen of phenylR.sub.4 is hydrogen or alkyl of 1-6 carbon atoms, andR.sub.5 is hydrogen, alkyl of 1-6 carbon atoms, cyclohexyl or phenylwith the proviso that at least one of the substituents R.sub.3, R.sub.4, and R.sub.5 is different from hydrogen, or physiologically acceptable salts thereof with an acid,have valuable pharmacological properties.Type: GrantFiled: September 6, 1983Date of Patent: November 26, 1985Assignee: Schering AktiengesellschaftInventors: Clemens Rufer, Irmgard Boettcher
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Patent number: 4503049Abstract: Diphosphonic acid derivatives of Formula I ##STR1## wherein R is hydrogen, an alkali metal atom, an alkaline earth metal atom, or an alkyl group of 1-4 carbon atoms andA is derived from a carboxylic acid having anti-inflammatory and antiphlogistic activity and containing an aromatic or heteroaromatic group, of Formula IIACOOH (II),are pharmacologically efficacious compounds.Type: GrantFiled: January 27, 1983Date of Patent: March 5, 1985Assignee: Schering AktiengesellschaftInventors: Helmut Biere, Clemens Rufer, Irmgard Boettcher
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Patent number: 4473560Abstract: Compounds of the formula ##STR1## wherein n is 0, 1, or 2;R.sup.1 is hydrogen or alkyl of 1-4 carbon atoms;R.sup.2 is hydrogen, an alkali metal atom, an alkaline earth metal atom, or alkyl of 1-4 carbon atoms; andAr is phenyl; phenyl substituted by fluorine, chlorine, alkyl of 1-4 carbon atoms, or alkoxy of 1-4 carbon atoms; naphthyl; biphenyl; or thienyl;or when R.sup.2 is H, a physiologically acceptable salt thereof with an organic basehave valuable antiinflammatory properties.Type: GrantFiled: January 27, 1983Date of Patent: September 25, 1984Assignee: Schering AktiengesellschaftInventors: Helmut Biere, Clemens Rufer, Irmgard Boettcher
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Patent number: 4411910Abstract: Benzofuran derivatives of the formula ##STR1## wherein V is hydrogen or acetyl,X is oxo or two hydrogen atoms,R.sub.1 and R.sub.2 each independently is hydrogen, fluorine, or chlorine, and--A--B-- is --O--CH.sub.2 -- or --CH.sub.2 --O--,possess valuable pharmacological properties.Type: GrantFiled: March 11, 1982Date of Patent: October 25, 1983Assignee: Schering AktiengesellschaftInventors: Eberhard Schroeder, deceased, Manfred Lehman, Clemens Rufer
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Patent number: 4407823Abstract: Phenylacetic acid derivatives of the formula ##STR1## wherein n is an integer of 2 to 5; ##STR2## R.sub.1 is hydrogen, halogen, trifluoromethyl, nitro or amino; R.sub.2 and R.sub.3 each independently is hydrogen or lower alkyl; or together form an ethylene group;X.sub.1 represents two hydrogen atoms or an oxo group; andY.sub.1 is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl or carboxyl;and for derivatives wherein Y is carboxyl, salts thereof with physiologically compatible bases, esters thereof from physiologically acceptable alcohols and amides thereof from physiologically acceptable amines have valuable pharmacological activity, e.g., as antiinflammatory agents.Type: GrantFiled: November 5, 1979Date of Patent: October 4, 1983Assignee: Schering AktiengesellschaftInventors: Gerald Kirsch, Joachim-Friedrich Kapp, Clemens Rufer
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Patent number: 4375479Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, methanesulfonyl, or acetyl,R.sub.2 and R.sub.3 jointly mean oxo, oximino, or separately two hydrogen atoms, orR.sub.2 is hydrogen and R.sub.3 is hydroxy or amino, and when R.sub.3 is amino, the physiologically acceptable acid salts thereofpossess valuable pharmacological properties.Type: GrantFiled: January 27, 1982Date of Patent: March 1, 1983Assignee: Schering AktiengesellschaftInventors: Eberhard Schroeder, deceased, Clemens Rufer
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Patent number: 4244960Abstract: Indanyl derivatives of the formula ##STR1## wherein AR is phenyl, pyridyl, or phenyl or pyridyl substituted by halogen, alkyl of 1-4 carbon atoms or trifluoromethyl; X is oxygen or a sulfur; R.sub.1 is alkyl of 1-4 carbon atoms or alkyl of 1-4 carbon atoms substituted by fluorine or chlorine; A is ##STR2## Y is oxo, oximino, C.sub.1-4 -alkoximino of 1-4 carbon atoms, phenylhydrazono or p-toluenesulfonylhydrazono; n is 0, 1 or 2; R.sub.2 is alkyl of 1-4 carbon atoms, phenyl or phenyl substituted by halogen, alkyl of 1-4 carbon atoms, nitro or carboxy; Z is hydroxy, acyloxy of 1 to 6 carbon atoms, R.sub.1 SO.sub.3 -- amino, acylamino of 1 to 6 carbon atoms, R.sub.1 SO.sub.2 NH-- or cyano, and V is hydrogen, acyl of 1 to 6 carbon atoms or R.sub.1 SO.sub.2 --, and the salts thereof with physiologically acceptable bases or acids have valuable pharmacological and herbicidal activity.Type: GrantFiled: July 27, 1979Date of Patent: January 13, 1981Assignee: Schering, AktiengesellschaftInventors: Eberhard Schroder, Clemens Rufer, Irmgard Bottcher, Joachim-Friedrich Kapp
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Patent number: 4058619Abstract: Thiophene derivatives of the formula ##STR1## WHEREIN R.sub.x is --S-CHR.sub.5 -COOH or --S-CH.sub.2 -CH.sub.2 -OH, R.sub.y is 1-2 of halogen alkoxy of 1-6 carbon atoms, aralkyl of 7-10 carbon atoms, phenyl, halophenyl or alkylcarbonyl of 1-6 carbon atoms in the alkyl group, and R.sub.5 is a hydrogen atom, when R.sub.y is a halogen atom, when R.sub.5 is alkyl, their enantiomers, and their pharmacologically acceptable salts thereof with bases, possess antilipolytic activity.Type: GrantFiled: September 14, 1976Date of Patent: November 15, 1977Assignee: Schering AktiengesellschaftInventors: Hanns Ahrens, Helmut Biere, Clemens Rufer, Ralph Schmiechen, Eberhard Schroeder, Olaf Loge, Wolfgang Losert, Ekkehard Schillinger
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Patent number: 4057640Abstract: Carbazoles of the formula ##STR1## wherein R.sub.1 is hydroxymethyl, alkanoyloxymethyl, tetrazolyl, cyano, oximinocarbonyl, aminocarbonyl, carboxyl and salts thereof with physiologically acceptable bases and the esters thereof with physiologically acceptable alcohols and amides thereof with physiologically acceptable amines,R.sub.2 through R.sub.6 each are a hydrogen atom, halogen atom, lower alkyl, trifluoromethyl, or lower alkoxy, orR.sub.5 and R.sub.6 collectively are a five- or six-membered isocyclic ring, andR.sub.7 is a hydrocarbon of 3-8 carbon atoms or, when at least one of the R.sub.2 through R.sub.6 is other than a hydrogen atom, a hydrogen atom, methyl or ethyl,And the corresponding compounds wherein R.sub.7 is a hydrogen atom, methyl or ethyl,And the 5,6,7,8-tetrahydrocarbazoles, possess topical anti-inflammatory activity.Type: GrantFiled: May 6, 1976Date of Patent: November 8, 1977Assignee: Schering AktiengesellschaftInventors: Helmut Biere, Hanns Ahrens, Clemens Rufer, Eberhard Schroder, Henning Koch
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Patent number: 4053472Abstract: 2-(5-Nitro-2-imidazolyl)-benzimidazoles of the formula ##STR1## wherein R.sub.1 and R.sub.2 are H, halo, alkyl, alkoxy, nitro, trifluoromethyl or carboxy; A is H, alkyl, hydroxyalkyl or an ester thereof, haloalkyl, phenyl or a tertiary aminoalkyl group; and X is alkyl, hydroxyalkyl or an ester thereof, are antimicrobials, especially against Trichomonas vaginalis.Type: GrantFiled: September 11, 1972Date of Patent: October 11, 1977Assignee: Schering AktiengesellschaftInventors: Clemens Rufer, Eberhard Schroder, Hans-Joachim Kessler
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Patent number: 4038410Abstract: Nitroimidazoles of the formula ##STR1## wherein R is dialkylaminoacryloyl; 3-, 4-, or 5-pyrazolyl or a mixture thereof which is unsubstituted or substituted by alkyl or, at the 1-position, by hydroxyalkyl or a nitro ester thereof, acyloxyalkyl, nitro, phenyl or phenyl p-substituted by halo, alkoxy or nitro, or, in the 3- or 5-position or a mixture thereof by nitro; 3- or 5-alkyl-4-isooxazolyl or a mixture thereof; or 4-alkyl-5-pyrimidinyl, unsubstituted or substituted by alkyl, amino, 2-furyl or 5-nitro-2-furyl, and the physiologically acceptable acid addition salts thereof, possess anti-protozoal activity, e.g., against trichomonas vaginalis and Entamoeba histolytica.Type: GrantFiled: March 12, 1975Date of Patent: July 26, 1977Assignee: Schering AktiengesellschaftInventors: Clemens Rufer, Katica Schwarz, Hans-Joachim Kessler
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Patent number: 4031236Abstract: Thiophene derivatives of the formula ##STR1## IN WHICH R.sub.x is --S--CHR.sub.5 --CONHOH or --S--CHR.sub.5 -5-tetrazolyl in which R.sub.5 is H or alkyl of 1-6 carbon atoms and R.sub.y is 0-2 of alkyl or alkoxy of 1-6 carbon atoms or halogen, and their pharmacologically acceptable salts with bases, possess antilipolytic activity.Type: GrantFiled: May 20, 1975Date of Patent: June 21, 1977Assignee: Schering AktiengesellschaftInventors: Hanns Ahrens, Helmut Biere, Clemens Rufer, Ralph Schmiechen, Eberhard Schroeder, Olaf Loge, Wolfgang Losert, Ekkehard Schillinger
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Patent number: 4021450Abstract: Thiophene derivatives of the formula ##STR1## WHEREIN R.sub.x is --S-CHR.sub.5 -COOH or -S-CH.sub.2 -CH.sub.2 -OH, R.sub.y is 1-2 of halogen alkoxy of 1-6 carbon atoms, aralkyl of 7-10 carbon atoms, phenyl, halophenyl or alkylcarbonyl of 1-6 carbon atoms in the alkyl group, and R.sub.5 is a hydrogen atom, when R.sub.y is a halogen atom, when R.sub.5 is alkyl, their enantiomers, and their pharmacologically acceptable salts thereof with bases, possess antilipolytic activity.Type: GrantFiled: May 20, 1975Date of Patent: May 3, 1977Assignee: Schering AktiengesellschaftInventors: Hanns Ahrens, Helmut Biere, Clemens Rufer, Ralph Schmiechen, Eberhard Schroeder, Olaf Loge, Wolfgang Losert, Ekkehard Schillinger
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Patent number: 3992374Abstract: Amino-substituted nitroimidazolyl-methyleneaminoimidazolidinones of the formula ##SPC1##Wherein --NR.sub.2 R.sub.3 is dialkylamino or heterocyclic amino, and the physiologically acceptable salts thereof, possess antitrichomonial activity.Type: GrantFiled: June 28, 1974Date of Patent: November 16, 1976Assignee: Schering AktiengesellschaftInventors: Clemens Rufer, Hans-Joachim Kessler
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Patent number: 3966732Abstract: Nitroimidazolyl pyrimidines of the formula ##SPC1##And physiologically acceptable acid addition salts thereon wherein X is alkyl of 1-4 carbon atoms, R.sub.1 and R.sub.2 each are a hydrogen atom, alkyl of 1-4 carbon atoms, phenyl triflouromethyl or a monocyclic heterocyclic ring and R.sub.3 is a hydrogen atoms, alkyl of 1-4 carbon atoms, hydroxyalkoxy of 2-4 carbon atoms or an ester thereof of an alkanocarboxylic acid of 1-4 carbon atoms, oxoalkyl of 8-6 carbon atoms, or, when R.sub.1 or R.sub.2 is phenyl, alkylene having 1-2 carbon atoms in the chain joined to the 2-position of the phenyl ring possess trichomonicidal activity.Type: GrantFiled: April 14, 1975Date of Patent: June 29, 1976Assignee: Schering AktiengesellschaftInventors: Clemens Rufer, Eberhard Schroder, Hans-Joachim Kessler
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Patent number: 3962471Abstract: Indolylacetylamino acids of the formula ##SPC1##Wherein R is H or CH.sub.3, physiologically acceptable salts thereof and the corresponding amides, alkyl and benzyl esters and alkyl and benzyl ethers thereof, possess anti-inflammatory activity.Type: GrantFiled: March 12, 1975Date of Patent: June 8, 1976Assignee: Schering AktiengesellschaftInventors: Helmut Biere, Hanns Ahrens, Clemens Rufer, Eberhard Schroder, Henning Koch
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Patent number: 3962453Abstract: Compounds of the formula ##SPC1##Wherein X and Y each are a bond or methylene, R is H or lower-alkyl and Z is a carboxyl, amide, nitrile or alkoxycarbonyl of 1-6 carbon atoms in the alkoxy group and the corresponding compounds bearing 1-2 halogen, lower-alkyl or lower-alkoxy groups on one or both benzene rings and, when Z is carboxyl, salts thereof with physiologically acceptable bases, possess anti-inflammatory and antipyretic activities.Type: GrantFiled: September 12, 1974Date of Patent: June 8, 1976Assignee: Schering AktiengesellschaftInventors: Hans Ahrens, Helmut Biere, Clemens Rufer, Eberhard Schroder, Henning Koch
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Patent number: 3960949Abstract: 1,2-Substituted biguanides of the formula ##EQU1## wherein R.sub.1 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; a cycloalkyl group of 3-6 carbon atoms; or an aryl or aralkyl group of the formula ##SPC1##With n being the integer 0, 1 or 2 and X being hydrogen or halogen; and R'.sub.1 is a hydrogen atom or a saturated or unsaturated, straight-chain or branched hydrocarbon group of 1-12 carbon atoms; or R.sub.1 and R'.sub.1 collectively with the nitrogen atom to which they are attached are a heterocyclic ring containing one or more hetero atoms; and R.sub.Type: GrantFiled: July 9, 1974Date of Patent: June 1, 1976Assignee: Schering AktiengesellschaftInventors: Hanns Ahrens, Clemens Rufer, Helmut Biere, Eberhard Schroder, Wolfgang Losert, Olaf Loge, Ekkehard Schillinger
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Patent number: 3956295Abstract: Carbazoles of the formula ##SPC1##Wherein R.sub.1 is hydroxymethyl, alkanoyloxymethyl, tetrazolyl, cyano, oximinocarbonyl, aminocarbonyl, carboxyl and salts thereof with physiologically acceptable bases and the esters thereof with physiologically acceptable alcohols and amides thereof with physiologically acceptable amines,R.sub.2 through R.sub.6 each are a hydrogen atom, halogen atom, lower alkyl, trifluoromethyl, or lower alkoxy, orR.sub.5 and R.sub.6 collectively are a five- or six-membered isocyclic ring, andR.sub.7 is a hydrocarbon of 3-8 carbon atoms or, when at least one of the R.sub.2 through R.sub.6 is other than a hydrogen atom, a hydrogen atom, methyl or ethyl,And the corresponding compounds wherein R.sub.7 is a hydrogen atom, methyl or ethyl,And the 5,6,7,8-tetrahydrocarbazoles, possess topical anti-inflammatory activity.Type: GrantFiled: July 17, 1974Date of Patent: May 11, 1976Assignee: Schering AktiengesellschaftInventors: Helmut Biere, Hanns Ahrens, Clemens Rufer, Eberhard Schroder, Henning Koch