Abstract: A “Smart Micro-catheter” (SMC) system comprising a device for controlled particle release and drug delivery into a blood vessel, hepatic artery or any patho-physiological target is disclosed. Methods of using the micro-catheter system for optimal targeted delivery of therapeutic microspheres comprising using subject-specific computer simulations of particle-hemodynamics are further provided.

Abstract: A “Smart Micro-catheter” (SMC) system comprising a device for controlled particle release and drug delivery into a blood vessel, hepatic artery or any patho-physiological target is disclosed. Methods of using the micro-catheter system for optimal targeted delivery of therapeutic microspheres comprising using subject-specific computer simulations of particle-hemodynamics are further provided.

Abstract: A smart inhaler system comprising an inhaler device for directed aerosol delivery facilitated by an adaptive nozzle and a mechanism for inhalation waveform modulation is provided. Methods of using the smart inhaler system for delivering an active agent to a target area of a lung of a subject are further provided.

Abstract: A surgical cutting device that clamps and cuts a graft creating optimal geometry for end-to-end anastomosis is disclosed. Methods of making and using the surgical cutting device are also disclosed.

Abstract: A smart inhaler system comprising an inhaler device for directed aerosol delivery facilitated by an adaptive nozzle and a mechanism for inhalation waveform modulation is provided. Methods of using the smart inhaler system for delivering an active agent to a target area of a lung of a subject are further provided.

Abstract: A bioreactor arrangement comprises a housing defining a closed space having a longitudinal axis with at least two spaced apart microporous membranes fixed therein dividing the space into a first chamber on one side of one of the membrane, a second chamber on one side of the other membrane, and a third chamber between opposite sides of the one and other membrane. The housing includes at least one port communicating with each chamber and fixed static mixers in the form of curved and/or perforated members in the third chamber. The first and second chambers are used alternately to receive and discharge material in the bioreactor. The third chamber contains an active substance which produces a useful product from raw materials in the supplied fluid. A flow valve and pump are provided for selectively supplying fluid carrying raw material to one or the other of the first and second chambers.