Patents by Inventor Clet Niyikiza

Clet Niyikiza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GAMMA POLYGLUTAMATED RALTITREXED AND USES THEREOF
    Publication number: 20210023006
    Abstract: The disclosure relates generally to gamma polyglutamated raltitrexed compositions, including delivery vehicles such as liposomes containing the gamma polyglutamated raltitrexed, and methods of making and using the gamma polyglutamated raltitrexed compositions to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., inflammation and autoimmune diseases such as rheumatoid arthritis).
    Type: Application
    Filed: February 7, 2019
    Publication date: January 28, 2021
    Inventors: Clet NIYIKIZA, Victor Mandla MOYO
  • ALPHA POLYGLUTAMATED PEMETREXED AND USES THEREOF
    Publication number: 20200360388
    Abstract: The disclosure relates generally to alpha polyglutamated pemetrexed, formulations containing liposomes filled with alpha polyglutamated pemetrexed, methods of making the alpha polyglutamated pemetrexed and liposome containing formulations, and methods of using polyglutamated alpha polyglutamated pemetrexed and liposome containing formulations to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).
    Type: Application
    Filed: February 7, 2019
    Publication date: November 19, 2020
    Inventors: Clet NIYIKIZA, Victor Mandla MOYO
  • ALPHA POLYGLUTAMATED PRALATREXATE AND USES THEREOF
    Publication number: 20200360390
    Abstract: The disclosure relates generally to alpha polyglutamated pralatrexate, formulations containing liposomes filled with alpha polyglutamated pralatrexate, methods of making the alpha polyglutamated pralatrexate and liposome containing formulations, and methods of using polyglutamated alpha polyglutamated pralatrexate and liposome containing formulations to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).
    Type: Application
    Filed: February 7, 2019
    Publication date: November 19, 2020
    Inventors: Clet NIYIKIZA, Victor Mandla MOYO
  • GAMMA POLYGLUTAMATED ANTIFOLATES AND USES THEREOF
    Publication number: 20200360389
    Abstract: The disclosure relates generally to gamma polyglutamated Antifolate, formulations containing liposomes filled with gamma polyglutamated Antifolate, methods of making the gamma polyglutamated Antifolate and liposome containing formulations, and methods of using polyglutamated gamma polyglutamated Antifolate and liposome containing formulations to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., inflammation and an autoimmune disease such as rheumatoid arthritis).
    Type: Application
    Filed: February 7, 2019
    Publication date: November 19, 2020
    Inventors: Clet NIYIKIZA, Victor Mandla MOYO
  • Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
    Patent number: 10744130
    Abstract: Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: August 18, 2020
    Assignee: Ipsen Biopharm Ltd.
    Inventors: Eliel Bayever, Navreet Dhindsa, Jonathan Basil Fitzgerald, Peter Laivins, Victor Moyo, Clet Niyikiza, Jaeyeon Kim
  • POLYGLUTAMATED ANTIFOLATES AND USES THEREOF
    Publication number: 20190307755
    Abstract: The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with the polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using the polyglutamated antifolates and liposome containing formulations to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).
    Type: Application
    Filed: August 12, 2017
    Publication date: October 10, 2019
    Inventors: Clet NIYIKIZA, Victor Mandla MOYO
  • PLATINUM COMPLEXES AND USES THEREOF
    Publication number: 20190231690
    Abstract: The disclosure generally relates to compositions comprising therapeutic agent complexes and to methods of making and using the compositions. In particular embodiments, the disclosure provides compositions comprising platinum-based drug complexes and to methods of making and using these compositions.
    Type: Application
    Filed: November 8, 2018
    Publication date: August 1, 2019
    Inventors: CLET NIYIKIZA, VICTOR M. MOYO
  • ALPHA AND GAMMA-D POLYGLUTAMATED ANTIFOLATES AND USES THEREOF
    Publication number: 20190224334
    Abstract: The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with alpha or D-gamma polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using polyglutamated antifolates and liposome containing formulations to treat hyerproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).
    Type: Application
    Filed: August 12, 2017
    Publication date: July 25, 2019
    Inventors: Clet NIYIKIZA, Victor Mandla MOYO
  • Methods For Treating Pancreatic Cancer Using Combination Therapies
    Publication number: 20190117644
    Abstract: Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.
    Type: Application
    Filed: June 19, 2018
    Publication date: April 25, 2019
    Applicant: Ipsen Biopharm Ltd.
    Inventors: Eliel Bayever, Navreet Dhindsa, Jonathan Basil Fitzgerald, Peter Laivins, Victor Moyo, Clet Niyikiza, Jaeyeon Kim
  • Methods For Treating Pancreatic Cancer Using Combination Therapies Comprising Liposomal Irinotecan
    Publication number: 20190117643
    Abstract: Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.
    Type: Application
    Filed: June 19, 2018
    Publication date: April 25, 2019
    Applicant: Ipsen Biopharm Ltd.
    Inventors: Eliel Bayever, Navreet Dhindsa, Jonathan Basil Fitzgerald, Peter Laivins, Victor Moyo, Clet Niyikiza, Jaeyeon Kim
  • ALPHA AND GAMMA-D POLYGLUTAMATED ANTIFOLATES AND USES THEREOF
    Publication number: 20180236098
    Abstract: The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with alpha or D-gamma polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using polyglutamated antifolates and liposome containing formulations to treat hyerproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).
    Type: Application
    Filed: August 11, 2017
    Publication date: August 23, 2018
    Inventors: Clet NIYIKIZA, Victor Mandla MOYO
  • Methods for Treating Pancreatic Cancer Using Combination Therapies
    Publication number: 20180008591
    Abstract: Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.
    Type: Application
    Filed: July 31, 2017
    Publication date: January 11, 2018
    Inventors: Eliel Bayever, Navreet Dhindsa, Jonathan Basil Fitzgerald, Peter Laivins, Victor Moyo, Clet Niyikiza, Jaeyeon Kim
  • METHODS FOR TREATING PANCREATIC CANCER USING COMBINATION THERAPIES COMPRISING LIPOSOMAL IRINOTECAN
    Publication number: 20170368056
    Abstract: Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.
    Type: Application
    Filed: July 18, 2017
    Publication date: December 28, 2017
    Inventors: Eliel Bayever, Navreet Dhindsa, Jonathan Basil Fitzgerald, Peter Laivins, Victor Moyo, Clet Niyikiza, Jaeyeon Kim
  • TARGETED LIPOSOMAL GEMCITABINE COMPOSITIONS AND METHODS THEREOF
    Publication number: 20170319482
    Abstract: This disclosure relates to a targeted PEGylated liposomal gemcitabine (PLG) composition comprising a PEGylated liposome encapsulating one or more agents comprising gemcitabine and a targeting moiety; pharmaceutical composition and methods comprising PLG or producing PLG; and manufacturing equipment for performing the methods.
    Type: Application
    Filed: May 4, 2017
    Publication date: November 9, 2017
    Inventors: Clet NIYIKIZA, Victor MOYO, Zhenghong XU, Kaniz KHALIFA
  • Methods for treating pancreatic cancer using combination therapies
    Patent number: 9717724
    Abstract: Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: August 1, 2017
    Assignee: Ipsen Biopharm Ltd.
    Inventors: Eliel Bayever, Navreet Dhindsa, Jonathan Basil Fitzgerald, Peter Laivins, Victor Moyo, Clet Niyikiza, Jaeyeon Kim
  • TREATMENT OF PANCREATIC CANCER WITH LIPOSOMAL IRINOTECAN
    Publication number: 20170202840
    Abstract: A liposome-encapsulated formulation of irinotecan can be used for the treatment of pancreatic cancer in combination with 5-fluorouracil and leucovorin, including treatment of patients diagnosed with metastatic adenocarcinoma of the pancreas who have been previously treated with gemcitabine.
    Type: Application
    Filed: January 11, 2017
    Publication date: July 20, 2017
    Inventors: Eliel Bayever, Navreet Dhindsa, Jonathan Basil Fitzgerald, Peter Laivins, Victor Moyo, Clet Niyikiza, Jaeyeon Kim
  • METHODS FOR TREATING PANCREATIC CANCER USING COMBINATION THERAPIES COMPRISING LIPOSOMAL IRINOTECAN
    Publication number: 20170065578
    Abstract: Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.
    Type: Application
    Filed: November 2, 2016
    Publication date: March 9, 2017
    Inventors: Eliel Bayever, NAVREET DHINDSA, JONATHAN BASIL FITZGERALD, PETER LAIVINS, VICTOR MOYO, CLET NIYIKIZA, JAEYEON KIM
  • METHODS FOR TREATING PANCREATIC CANCER USING COMBINATION THERAPIES
    Publication number: 20170049768
    Abstract: Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.
    Type: Application
    Filed: November 2, 2016
    Publication date: February 23, 2017
    Inventors: Eliel Bayever, Navreet Dhindsa, Jonathan Basil Fitzgerald, Peter Laivins, Victor Moyo, Clet Niyikiza, Jaeyeon Kim, Bambang Adiwijaya
  • Methods for Treating Pancreatic Cancer Using Combination Therapies
    Publication number: 20160375004
    Abstract: Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 29, 2016
    Inventors: ELIEL BAYEVER, NAVREET DHINDSA, JONATHAN BASIL FITZGERALD, PETER LAIVINS, VICTOR MOYO, CLET NIYIKIZA, JAEYEON KIM
  • Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
    Patent number: 9492442
    Abstract: Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the liposomal irinotecan (MM-398) is co-administered with 5-fluorouracil and leucovorin.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: November 15, 2016
    Assignee: Merrimack Pharmaceuticals, Inc.
    Inventors: Eliel Bayever, Navreet Dhindsa, Jonathan Basil Fitzgerald, Peter Laivins, Victor Moyo, Clet Niyikiza, Jaeyeon Kim