Abstract: An arrangement including a suction pump, a pipette, an application tip and a plurality of ligating rings which are carried on the application tip. The application tip is disposed in cooperative relation with the pipette so that the ligating rings may be transferred from the adapter tip to the pipette while being gradually stretched. The pipette is disposed in an incision exposing the ovarian sack of a small mammalian creature, whereupon a suction or vacuum is generated by the pump to capture the ovarian sack, after which a ligating ring is slipped off of the pipette and contracts to ligate said captured sack. This enables resorption of the ligated ovarian sack into the creature and stabilization of hormonal activity as is desired for experimental purposes.

Abstract: A squeeze-type bottle of the type containing a liquid, a syphon tube extending within the liquid and a nozzle communicating with the syphon tube includes an anti-syphon device disposed between the syphon tube and the nozzle, whereby expulsion of the liquid due to a pressure differential between the inside and the outside of the bottle when the bottle is not being used is prevented. The anti-syphon device is such that the bottle may be used in an inverted position.