Abstract: Provided herein are compounds comprising compounds of formula I and/or salts thereof; wherein at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine, and the remainder are independently chosen from hydrogen and fluorine; and R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23 are independently chosen from hydrogen and deuterium; with the proviso that when R1, R2, and R3 are fluorine, then at least one of R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine or at least one of R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23 is deuterium. Also provided are medicaments comprising these compounds and methods for treating central nervous system disorders with the compounds and medicaments described herein.

Abstract: Provided herein are compounds comprising compounds of formula I and/or salts thereof; wherein at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine, and the remainder are independently chosen from hydrogen and fluorine; and R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23 are independently chosen from hydrogen and deuterium; with the proviso that when R1, R2, and R3 are fluorine, then at least one of R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is fluorine or at least one of R14, R15, R16, R17, R18, R19, R20, R21, R22, and R23 is deuterium. Also provided are medicaments comprising these compounds and methods for treating central nervous system disorders with the compounds and medicaments described herein.

Abstract: A substantially oil- and fat-free single phase, homogenous antioxidant formulation that is readily dispersible in lipid matrices at ambient temperature by gentle stirring. The formulation includes a phenolic antioxidant compound, a liquid carrier, preferably a metal chelator, an emulsifier, and a polarity modifier. In preferred embodiment, a combination of lipid-soluble and water-soluble antioxidant compounds is included to provide an improved antioxidant effect.

Abstract: Provided herein is a magnetic agitator, comprising a magnet, a body having a central axis; and a plurality of spines, each spine having a shaft and a termination, wherein the shaft smoothly transitions from the body; wherein the body and spines are adapted to enhance mixing when the agitator is stirred in a vessel.

Abstract: The thermal stability of enzymes is improved by incorporating the enzyme in a matrix of a non-reducing sugar, such as trehalose. Heat-stable compositions of enzymes and sugar are formed by adding the enzymes to a sugar syrup and drying the mixture either by spreading it on a carrier or by spray drying. The enzyme compositions retain higher levels of activity after being subjected to heat in product-forming processes, such as steam pelleting of animal feed supplemented with the enzyme compositions.

Abstract: A substantially oil- and fat-free single phase, homogenous antioxidant formulation that is readily dispersible in lipid matrices at ambient temperature by gentle stirring. The formulation includes a phenolic antioxidant compound, a liquid carrier, preferably a metal chelator, an emulsifier, and a polarity modifier. In preferred embodiment, a combination of lipid-soluble and water-soluble antioxidant compounds is included to provide an improved antioxidant effect.

Abstract: There is provided a method of using a remote laser source to manipulate a space object having a target, comprising projecting a beam from the remote laser source, wherein the beam has a sufficient intensity and wavelength to cause ablation at a position on the target; imparting an impulse to the space object having the target; modifying at least one beam characteristic selected from the group consisting of intensity, wavelength and position on the target, wherein the position and/or orientation of the space object is altered relative to the remote laser source.

Abstract: An audio amplifier and speaker system are stacked and magnetically coupled together. The audio amplifier is coupled for receiving an audio signal. A first securing assembly is provided on a bottom surface of the amplifier. The first securing assembly may be a foot formed on the bottom surface of the audio amplifier. The speaker is electrically coupled to the amplifier. A second securing assembly is provided on a top surface of the speaker. The second securing assembly may be a receptacle formed in top surface of the speaker. The foot is inserted into the receptacle. The foot and receptacle are magnetically coupled to attach the amplifier to the speaker. The foot has a first electrical connector, and the receptacle has a second electrical connector mated to the first electrical connector to route the audio signal from the amplifier to the speaker.

Abstract: The thermal stability of enzymes is improved by incorporating the enzyme in a matrix of a non-reducing sugar, such as trehalose. Heat-stable compositions of enzymes and sugar are formed by adding the enzymes to a sugar syrup and drying the mixture either by spreading it on a carrier or by spray drying. The enzyme compositions retain higher levels of activity after being subjected to heat in product-forming processes, such as steam pelleting of animal feed supplemented with the enzyme compositions.

Abstract: A method was developed for the screening of antioxidant efficacy in food and feed matrices. The novel method uses radical initiators to accelerate the oxidation process. Consequently the screening of the oxidation process can be performed at significantly lower temperatures compared to the existing methods. The use of initiators improves the correlation between accelerated screening and real shelf life. This resolves an important issue that is frequently raised concerning the applicability of accelerated oxidation tests conducted at high temperatures. Furthermore feed and food products can be analyzed in their original states because lower temperatures have less influence on the product matrix.

Abstract: A process for the solid-phase synthesis of salts of organic acids in a granular, free-flowing, and dust-free form particularly suited for use as animal feed additives. A mixture of liquid organic acids, including butyric acid, is applied to an inert, absorbent carrier. A solid base is then added during stirring. The acid is slowly released from the carrier preventing the fast reactions that lead to the formation of clumps. The exothermic reaction releases heat which assists in reducing the moisture content of the product. The addition of butyric acid results in a product which has an improved effect on animal growth over the animal feed additive without the addition of butyric acid.

Abstract: A method was developed for the screening of antioxidant efficacy in food and feed matrices. The novel method uses radical initiators to accelerate the oxidation process. Consequently the screening of the oxidation process can be performed at significantly lower temperatures compared to the existing methods. The use of initiators improves the correlation between accelerated screening and real shelf life. This resolves an important issue that is frequently raised concerning the applicability of accelerated oxidation tests conducted at high temperatures. Furthermore feed and food products can be analyzed in their original states because lower temperatures have less influence on the product matrix.

Abstract: An antioxidant formulation that is readily dispersible in lipid matrices at ambient temperature by gentle stirring. The formulation includes a phenolic antioxidant compound, a liquid carrier, preferably a metal chelator, an emulsifier, and a polarity modifier. In preferred embodiment, a combination of lipid-soluble and water-soluble antioxidant compounds is included to provide and improved antioxidant effect.

Abstract: A musical string instrument (12) has a body (21) with a resonate cavity covered by a soundboard (22). A pick guard (34) has a flat surface for mounting to the soundboard of the instrument. Electronic control components (36) are mounted within a housing of the pick guard. The musician can control a preamplifier within the resonate cavity of the body with knobs (58) and push buttons (60) located on the pick guard. A thin, flat, multi-conductor ribbon cable (38) is connected to the electronic control components and routed along a surface of the soundboard and through a sound hole (24) in the soundboard into the resonate cavity of the body. The ribbon cable entering the resonating cavity through the sound hole does not adversely effect the natural response, performance, sound quality, and tonal property of the string instrument and does not require any additional holes be drilled in the soundboard.

Abstract: An input signal is applied to a notch filter having a transfer function that is the inverse of the expected noise signal. The filtered signal is coupled to a first amplifier and the input signal is coupled to a second amplifier. The outputs of the amplifiers are summed. The gains of the amplifiers are oppositely adjusted in response to the magnitude of the input signal. At low amplitude, the filtered signal is amplified more than the unfiltered signal. At high amplitude, the unfiltered signal is amplified more than the filtered signal.

Abstract: A process for the solid-phase synthesis of salts of organic acids in a granular, free-flowing, and dust-free form particularly suited for use as animal feed additives. A mixture of liquid organic acids, including butyric acid, is applied to an inert, absorbent carrier. A solid base is then added during stirring. The acid is slowly released from the carrier preventing the fast reactions that lead to the formation of clumps. The exothermic reaction releases heat which assists in reducing the moisture content of the product. The addition of butyric acid results in a product which has an improved effect on animal growth over the animal feed additive without the addition of butyric acid.

Abstract: A musical string instrument (12) has a body (21) with a resonate cavity covered by a soundboard (22). A pick guard (34) has a flat surface for mounting to the soundboard of the instrument. Electronic control components (36) are mounted within a housing of the pick guard. The musician can control a preamplifier within the resonate cavity of the body with knobs (58) and push buttons (60) located on the pick guard. A thin, flat, multi-conductor ribbon cable (38) is connected to the electronic control components and routed along a surface of the soundboard and through a sound hole (24) in the soundboard into the resonate cavity of the body. The ribbon cable entering the resonating cavity through the sound hole does not adversely effect the natural response, performance, sound quality, and tonal property of the string instrument and does not require any additional holes be drilled in the soundboard.

Abstract: An input signal is applied to a notch filter having a transfer function that is the inverse of the expected noise signal. The filtered signal is coupled to a first amplifier and the input signal is coupled to a second amplifier. The outputs of the amplifiers are summed. The gains of the amplifiers are oppositely adjusted in response to the magnitude of the input signal. At low amplitude, the filtered signal is amplified more than the unfiltered signal. At high amplitude, the unfiltered signal is amplified more than the filtered signal.

Abstract: A combination of limited data, 3D linear interpolation, and a unique simulation circuit are combined to provide a programmable tone control that can simulate any desired tone stack. In accordance with one aspect of the invention, it has been found that a reduced number of data points plus interpolation provides sufficiently accurate coefficients for simulation. The data points are obtained from measurements of the actual operation of the analog tone stacks to be simulated. A second aspect of the invention is the simulation circuit controlled by the coefficients to accurately reproduce the operation of any given tone stack. The simulation circuit uses two programmable filters and three variable gain amplifiers to simulate a tone stack. The cut-off frequency of each filter and the gain of each amplifier are determined by coefficients extracted by interpolation from stored data.