Patents by Inventor Clifford C. Leznoff

Clifford C. Leznoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phthalocyanine and tetrabenztriazaporphyrin reagents
    Patent number: 5346670
    Abstract: Red-shifted, water-soluble, fluorescent, monomerically-tetherable derivatives having the formula: ##STR1##wherein, M represents either H.sub.2 or is selected from among the following metals: aluminum, silicon, phosphorus, gallium, germanium, cadmium, scandium, magnesium, tin, and zinc. Each R.sub.1 is independently selected from --XYW, --YW, and --W. X represents either a carbon, or heteroatom selected from among oxygen, nitrogen, sulfur, phosphorus, silicon, and selenium; Y represents a linking group; and W represents a water solubilizing group. The substituent R.sub.2 is selected from among --A, --Y'A, --XA, and --XY'A, where A denotes a biological entity such as an antibody, antibody fragment, nucleotide, nucleic acid probe, antigen, oligonucleotide, deoxynucleotide, dideoxynucleotide, avidin, streptavidin or membrane probe, or R.sub.2 is a reactive or activatable group suitable for conjugating to a biological entity.
    Type: Grant
    Filed: June 8, 1992
    Date of Patent: September 13, 1994
    Assignee: British Technology Group U.S.A. Inc.
    Inventors: George E. Renzoni, Deborah C. Schindele, Louis J. Theodore, Clifford C. Leznoff, Karen L. Fearon, Barry V. Pepich
  • Tetrabenztriazaporphyrin reagents and kits containing the same
    Patent number: 5135717
    Abstract: Red-shifted, water-soluble, fluorescent, monomerically-tetherable derivatives having the formula: ##STR1## wherein, M represents either H.sub.2 or is selected from among the following metals: aluminum, silicon, phosphorus, gallium, germanium, cadmium, scandium, magnesium, tin, and zinc. Each R.sub.1 is independently selected from --XYW, --YW, and --W. X represents either a carbon, or heteroatom selected from among oxygen, nitrogen, sulfur, phosphorus, silicon, and selenium; Y represents a linking group; and W represents a water solubilizing group. The substituent R.sub.2 is selected from among --A, --Y'A, --XA, and --XY'A, where A denotes a biological entity such as an antibody, antibody fragment, nucleotide, nucleic acid probe, antigen, oligonucleotide, deoxynucleotide, dideoxynucleotide, avidin, streptavidin or membrane probe, or R.sub.2 is a reactive or activatable group suitable for conjugating to a biological entity.
    Type: Grant
    Filed: August 29, 1989
    Date of Patent: August 4, 1992
    Assignee: British Technology Group USA Inc.
    Inventors: George E. Renzoni, Deborah C. Schindele, Louis J. Theodore, Clifford C. Leznoff, Karen L. Fearon, Barry V. Pepich
  • Trifluoroacetylation of unhindered primary and secondary amines and polymer-bound trifluoroacetylation reagents
    Patent number: 4758623
    Abstract: A trifluoroacetylthio- or trifluoroacetylthioalkyl-substituted divinyl benzene co-styrene polymer and a method for using such polymer are disclosed.
    Type: Grant
    Filed: July 17, 1986
    Date of Patent: July 19, 1988
    Assignee: Schering Corporation
    Inventor: Clifford C. Leznoff