Patents by Inventor Clifford D. Mol

Clifford D. Mol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mitotic Kinase Inhibitors
    Publication number: 20100093767
    Abstract: The invention relates to inhibitors of enzymes that disrupt the assembly and function of the mitotic spindle, compositions comprising the inhibitors of Formula (I), kits and articles of manufacture comprising the inhibitors and inhibitor compositions, and methods of using the inhibitors and inhibitor compositions. The inhibitors and inhibitor compositions are useful for treating, preventing or modulating diseases in which mitotic kinesins, including kinesin-like spindle protein (KSP), may be involved; symptoms of such diseases; or the effect of other physiological events mediated by mitotic kinesins, including KSP.
    Type: Application
    Filed: December 2, 2005
    Publication date: April 15, 2010
    Applicant: TAKEDA SAN DIEGO, INC.
    Inventors: Jerome C. Bressi, Andrew John Jennings, Stephen W. Kaldor, Lily Kwok, Clifford D. Mol, Jeffrey A. Stafford
  • DNA glycosylases and their use
    Patent number: 7662601
    Abstract: Novel cytosine-, thymine- and uracil-DNA glycosylases, subcellular localization peptides, nucleic acid molecules containing the same, methods of identifying such enzymes and their use in various methods including mutagenesis, cell killing and DNA sequencing and modification, are desired.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: February 16, 2010
    Inventors: Hans E. Krokan, Geir Slupphaug, Bodil Kavli, John A. Tainer, Clifford D. Mol
  • Crystallization of the catalytic domain of human phosphodiesterase 4-D3 (PDE4-D3)
    Patent number: 7556950
    Abstract: Provided are crystals relating to human phosphodiesterase 4-D3 (PDE4-D3), methods for forming crystals comprising PDE4-D3 and crystals comprising PDE4-D3 co-crystallized with a ligand molecule, and methods of using crystals comprising PDE4-D3.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: July 7, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, Ellen Chien, Douglas R. Dougan, Michelle L. Kraus, Clifford D. Mol, Gyorgy Snell
  • Crystallization of carboxyltransferase domain of Acetyl-CoEnzyme A Carboxylase 2 with a ligand
    Patent number: 7534592
    Abstract: Provided are crystals relating to the carboxyltransferase domain of human Acetyl-Coenzyme A Carboxylase 2 and its various uses.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: May 19, 2009
    Assignee: Takeda San Diego, Inc.
    Inventors: Douglas R. Dougan, Clifford D. Mol, Bi Ching Sang, Gyorgy Snell, Hua Zou
  • Crystallization of MAPK/ERK Kinase 2
    Patent number: 7368269
    Abstract: Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: May 6, 2008
    Assignee: Takeda San Diego, Inc.
    Inventors: Ciaran N. Cronin, Douglas R. Dougan, Mark W. Knuth, Michelle L. Kraus, Kheng Lim, Clifford D. Mol, Gyorgy Snell, Hua Zou
  • Crystallization of protein kinase B?/AKT1
    Patent number: 7309594
    Abstract: Provided are crystals relating to Protein kinase B?/AKT1 and its various uses.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: December 18, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, Ellen Y. T. Chien, Douglas R. Dougan, Andrew J. Jennings, Michelle L. Kraus, Clifford D. Mol
  • Crystallization of c-KIT tyrosine kinase leading to autoinhibited crystal structure
    Patent number: 7303893
    Abstract: Provided are crystals relating to the autoinhibited structure of c-KIT tyrosine kinase (c-KIT) and its various uses.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: December 4, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Ellen Chien, Ciaran N. Cronin, Douglas R. Dougan, Clifford D. Mol, Bi Ching Sang, Hua Zou
  • Crystallization of FMS-like tyrosine kinase 3
    Patent number: 7270987
    Abstract: Provided are crystals and structure coordinates relating to FMS-like tyrosine kinase 3 and its various uses.
    Type: Grant
    Filed: November 30, 2004
    Date of Patent: September 18, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Ellen Chien, Ciaran N. Cronin, Douglas R. Dougan, Kheng Lim, Clifford D. Mol, Bi Ching Sang, Garret Textor
  • Crystallization of Glucocorticoid Receptor
    Patent number: 7241868
    Abstract: Provided are crystals relating to human Glucocorticoid Receptor and its various uses.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: July 10, 2007
    Assignee: Takeda San Diego, Inc.
    Inventors: Alexei Brooun, Oleg Brodsky, Ellen Chien, Douglas R. Dougan, Clifford D. Mol, Gyorgy Snell
  • DNA glycosylases and their use
    Patent number: 6713294
    Abstract: Novel cytosine-, thymine- and uracil-DNA glycosylases, subcellular localization peptides, nucleic acid molecules containing the same, methods of identifying such enzymes and their use in various methods including mutagenesis, cell killing and DNA sequencing and modification, are described.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: March 30, 2004
    Inventors: Hans E. Krokan, Geir Slupphaug, Bodil Kavli, John A. Tainer, Clifford D. Mol