Abstract: The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent kinase inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for a protein kinase mediated disorder in which kinase is implicated, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth.

Abstract: Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

Abstract: According to a preferred embodiment of the present invention, a bridging system (100) and method provides a way of linking two independent data systems by receiving a dataset from a source data system. The bridging system (100) translates the dataset from a source schema to a target schema according to a set of mapping rules, and queues the translated data in persistent storage, and then sends the translated dataset to a destination data system. The system (100) includes an XML bridge (114), multiple application specific gateways (116,118), and a web admin interface (210), all in communication via a wide area network.

Abstract: The Pyrazolo[1,5-a]pyrimidine derivatives represented by formula I and their pharmaceutically acceptable salts exhibit excellent MAPKAP-K2 inhibiting activity. Drugs comprising the compounds as effective ingredients are therefore expected to be useful as therapeutic or prophylactic agents for MAPKAP-K2 mediated disorder, such as inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth.

Abstract: A lost article finding device, which can be used for, for example, finding keys and the like. The finding device has a element for automatically finding its location, such as a GPS device or other position detecting device. A transceiver receives requests from a remote location, and response to those requests. The requests may include periodic pings, which are simply sent to ensure that the device is responding to requests. The requests may also include specialized requests which specifically request the device to report its current location.

Abstract: A lost article finding device, which can be used for, for example, finding keys and the like. The finding device has a element for automatically finding its location, such as a GPS device or other position detecting device. A transceiver receives requests from a remote location, and response to those requests. The requests may include periodic pings, which are simply sent to ensure that the device is responding to requests. The requests may also include specialized requests which specifically request the device to report its current location.

Abstract: A controller-based radio frequency amplifier method and module are employed in a modular transmission system in which respective of the controller-based radio frequency amplifier modules amplify a portion of a signal that is input into the system. Each amplifier module includes an amplifier submodule have a plurality of discrete amplifiers arranged in an amplifier chain, a processor submodule is configured to control a level of the amplified output signal that is output from each amplifier module, a power supply module, and an enclosure. The processor submodule is configured to control the discrete amplifiers in the amplifier submodule such that the module may be removed or added to the system without damaging the power amplifier module or other system components.

Abstract: A controller-based radio frequency amplifier method and module are employed in a modular transmission system in which respective of the controller-based radio frequency amplifier modules amplify a portion of a signal that is input into the system. Each amplifier module includes an amplifier submodule have a plurality of discrete amplifiers arranged in an amplifier chain, a processor submodule is configured to control a level of the amplified output signal that is output from each amplifier module, a power supply module, and an enclosure. The processor submodule is configured to control the discrete amplifiers in the amplifier submodule such that the module may be removed or added to the system without damaging the power amplifier module or other system components.

Abstract: A controller-based radio frequency amplifier method and module are employed in a modular transmission system in which respective of the controller-based radio frequency amplifier modules amplify a portion of a signal that is input into the system. Each amplifier module includes an amplifier submodule have a plurality of discrete amplifiers arranged in an amplifier chain, a processor submodule is configured to control a level of the amplified output signal that is output from each amplifier module, a power supply module, and an enclosure. The processor submodule is configured to control the discrete amplifiers in the amplifier submodule such that the module may be removed or added to the system without damaging the power amplifier module or other system components.

Abstract: A controller-based radio frequency amplifier method and module are employed in a modular transmission system in which respective of the controller-based radio frequency amplifier modules amplify a portion of a signal that is input into the system. Each amplifier module includes an amplifier submodule have a plurality of discrete amplifiers arranged in an amplifier chain, a processor submodule is configured to control a level of the amplified output signal that is output from each amplifier module, a power supply module, and an enclosure. The processor submodule is configured to control the discrete amplifiers in the amplifier submodule such that the module may be removed or added to the system without damaging the power amplifier module or other system components.

Abstract: A computer program product is configured to control a modular transmission system having a control processor and at least N power amplifier modules, each having a controller submodule, wherein the system receives an input signal which may be a single carrier or multiple carriers. The signal is passed to a one-by-N divider which divides the signal N ways. Each of the N divided signals are independently amplified by the power amplifier (PA) modules "slices" (i.e., PA modules) that includes an RF amplifier module, a microcontroller module, and a power supply module, all of which are tightly coupled via a plurality of signal, power, control, and status connections. Each the PA slices amplifies its respective input signal and outputs a respective radio frequency output signal at a predetermined power level as controlled by the microcontrol module, the driver, and the system controller, or a network manager via a system input/output interface.

Abstract: A modular broadband transmission system and method include an input signal connector that receives an input signal which is then divided into N parts and amplified with an amplifier have N power amplifier modules. Outputs of the N power amplifier modules are passed through transmission lines and to a radial combiner that combines the outputs. The radial combiner, transmission lines and power amplifier modules are configured such that if one of the power amplifier modules fails, the other power amplifier modules may still operate acceptable well, with minimal impact on total output power. An output of the amplifier is provided to a coupler that measures a power level of the output signal and feeds the measured power level back to a controller where the controller adjust an overall output power based on the number of the power amplifier modules that are functioning properly.

Abstract: An explosive composition consisting of an explosive which contains an eleically conductive ingredient, and having a thermally conductive, electrically insulating substance incorporated therein in order to reduce the sensitivity of the composition to radio frequency.