Patents by Inventor Clifford J. Tabin

Clifford J. Tabin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR REPROGRAMMING FIBROBLASTS INTO LIMB PROGENITORS
    Publication number: 20240093156
    Abstract: The disclosure provides methods and compositions for reprogramming fibroblasts into limb progenitors.
    Type: Application
    Filed: August 15, 2023
    Publication date: March 21, 2024
    Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Clifford J. Tabin, Yuji Atsuta, Alan R. Rodrigues, ChangHee Lee, Olivier Pourquie
  • Vertebrate embryonic pattern-inducing proteins, and uses related thereto
    Patent number: 7781215
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: August 24, 2010
    Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
  • Vertebrate embryonic pattern-inducing proteins and uses related thereto
    Patent number: 7144732
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: December 5, 2006
    Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Institute
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
  • Methods and compositions for regulating skeletogenic formation
    Patent number: 6884775
    Abstract: The present application is directed to the discovery that hedgehog proteins, and agents which effect the activities thereof, can be used to control the formation and/or maintenance of cartilage and bone.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: April 26, 2005
    Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology, Inc.
    Inventors: Clifford J. Tabin, Andrew P. McMahon, Philip W. Ingham, Andrea M. Vortkamp
  • Vertebrate embryonic pattern inducing proteins and uses related thereto
    Publication number: 20040224882
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Application
    Filed: August 25, 2003
    Publication date: November 11, 2004
    Applicants: Imperial Cancer Research Technology Limited, President and Fellows of Harvard College
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
  • Oncogenes and methods for their detection
    Patent number: 6713619
    Abstract: Experiments designed to define the differences between the 21 oncogene of DNA isolated from human bladder cancer cells and its corresponding proto-oncogene are described herein. Also described is the determination of the difference between the rat neu oncogene and its corresponding proto-oncogene. Also described are nucleic acid probes reactive with regions of the proto-oncogene or oncogene, as are methods for their use in detecting the occurrence of the two types of genes. Antibodies specific for gene products encoded by the neu genes are also described, as are methods for their use.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: March 30, 2004
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert A. Weinberg, Clifford J. Tabin, Scott M. Bradley
  • Nucleic acids encoding hedgehog proteins
    Patent number: 6664075
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: December 16, 2003
    Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin, David A. Bumcrot, Elisa Marti-Gorostiza
  • Vertebrate tissue pattern-inducing proteins, and uses related thereto
    Publication number: 20030190696
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Application
    Filed: December 13, 2000
    Publication date: October 9, 2003
    Applicant: President and Fellows of Harvard College
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin, David A. Bumcrot, Elisa Marti-Gorostiza
  • Compositions comprising hedgehog proteins
    Patent number: 6630148
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: October 7, 2003
    Assignees: Imperial Cancer Research Technology Ltd., President and Fellows of Harvard College
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
  • VERTEBRATE EMBRYONIC PATTERN-INDUCING PROTEINS, AND USES RELATED THERETO
    Publication number: 20030186357
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Application
    Filed: June 5, 1995
    Publication date: October 2, 2003
    Inventors: PHILIP W. INGHAM, ANDREW P. MCMAHON, CLIFFORD J. TABIN
  • Method of promoting chondrocyte differentiation with hedgehog related polypeptides
    Patent number: 6610656
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: August 26, 2003
    Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology, Ltd.
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
  • Vertebrate embryonic pattern-inducing proteins and uses related thereto
    Patent number: 6607913
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: August 19, 2003
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
  • Vertebrate tissue pattern-inducing proteins, and uses related thereto
    Patent number: 6576237
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vetebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: June 10, 2003
    Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin, David A. Bumcrot, Elisa Marti-Gorostiza
  • VERTEBRATE EMBRYONIC PATTERN-INDUCING PROTEINS AND USES RELATED THERETO
    Publication number: 20030054437
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Application
    Filed: October 20, 1997
    Publication date: March 20, 2003
    Inventors: PHILIP w INGham, ANDREW P. MCMAHON, CLIFFORD J TABIN
  • Vertebrate embryonic pattern-inducing proteins
    Patent number: 6384192
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: May 7, 2002
    Assignees: President & Fellows of Harvard College, Imperial Cancer Research Technology, Ltd.
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
  • Nucleic acids encoding hedgehog proteins
    Patent number: 6271363
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: August 7, 2001
    Assignees: President & Fellows of Harvard College, Imperial Cancer Research Technology, Ltd.
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
  • Screening assays for hedgehog agonists and antagonists
    Patent number: 6261786
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: July 2, 1996
    Date of Patent: July 17, 2001
    Assignees: Imperial Cancer Res. Technology, President & Fellows of Harvard College
    Inventors: Valeria Marigo, Clifford J. Tabin, Philip W. Ingham, Andrew P. McMahon
  • Nucleic acids encoding hedgehog proteins
    Patent number: 6165747
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 26, 2000
    Assignees: President & Fellows of Harvard College, Imperial Cancer Research Technology, Ltd.
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin, David A. Bumcrot, Elisa Marti-Gorostiza
  • Fringe proteins and pattern formation
    Patent number: 6054298
    Abstract: Isolated DNA encoding a protein or polypeptide having at least one biological activity of a vertebrate fringe protein, as well as the protein or polypeptide encoded thereby, are described. Assays for identifying agents which alter the expression of the described fringe genes and assays for agents which alter the production of angiogenic precursors, the formation of the apical ectodermal ridge and the subdivisions of the neural tube are also described.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: April 25, 2000
    Assignee: President and Fellows of Harvard College
    Inventors: Edward M. Laufer, Olivia E. Orozco, Clifford J. Tabin
  • Vertebrate embryonic pattern-inducing proteins, and uses related thereto
    Patent number: 5844079
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Grant
    Filed: December 14, 1994
    Date of Patent: December 1, 1998
    Assignee: President and Fellows of Harvard College
    Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin