Patents by Inventor Clifford J. Woolf

Clifford J. Woolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOCICEPTOR NEURONS CONTROL CANCER IMMUNOSURVEILLANCE
    Publication number: 20230165812
    Abstract: The present disclosure provides methods of treating cancer by silencing tumor-innervating sensory neurons. The methods include treating cancer by genetic ablation of ion channels (e.g., TRPV1 or NaV1.8), local pharmacological silencing or blockade of neuropeptide release from tumor-innervating nociceptor (e.g., with QX-314 and BoNT/a), as well as the antagonism of the CGRP receptor RAMP1 (e.g., with BIBN 4096).
    Type: Application
    Filed: February 26, 2021
    Publication date: June 1, 2023
    Applicants: President and Fellows of Harvard College, Université de Montréal, Children's Medical Center Corporation
    Inventors: Clifford J. Woolf, Sebastien Talbot, Bruce P. Bean
  • Devices and methods for analyzing rodent behavior
    Patent number: 11432528
    Abstract: A device for detecting and recording animal behavior may include at least one corral that defines a contained field, the base surface of the at least one corral being sensitive to the animal's footprint. The device also includes an image capturing device that cooperates with the base surface to capture both a profile of the animal's full footprint and a profile of the animal's toe print when the animal is standing on its toes. In some embodiments, the device is capable of providing a stimulus to the animal and observing the resulting behavior of the animal via the image capturing device.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: September 6, 2022
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Clifford J. Woolf, David P. Roberson, Alexander B. Wiltschko, Sandeep Robert Datta
  • CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE
    Publication number: 20220041552
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation.
    Type: Application
    Filed: October 25, 2021
    Publication date: February 10, 2022
    Applicants: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf, Jinbo Lee, Sooyeon Jo, David P. Roberson, Sebastien Talbot
  • PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20220016046
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment or neurogenic inflammation.
    Type: Application
    Filed: September 17, 2021
    Publication date: January 20, 2022
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Clifford J. Woolf, Bruce P. Bean
  • BIOMARKERS OF NEUROPATHIC PAIN
    Publication number: 20210386365
    Abstract: This disclosure is related to methods of objectively detecting and measuring neuropathic pain in a subject.
    Type: Application
    Filed: June 13, 2019
    Publication date: December 16, 2021
    Inventors: Clifford J. Woolf, Alban A. Latremoliere, Thomas E. Scammell, Chloe M. Alexandre
  • PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20210290561
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.
    Type: Application
    Filed: June 2, 2021
    Publication date: September 23, 2021
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Clifford J. Woolf, Bruce P. Bean
  • TOPICAL TRPV1 ANTAGONISTS AND METHODS AND COMPOSITIONS THEREOF
    Publication number: 20210290524
    Abstract: The technology disclosed herein generally relates to the field of pain relief, and relates to a topical composition comprising a TRPV1 antagonist. The technology disclosed herein provides for methods, compositions and devices for topical application for the treatment of pain, allodynia or hyperalgesia associated with acute tissue injury, e.g., for the treatment of a wounds or tissue injury, including but not limited to incision, abrasion, laceration, puncture and avulsion. The methods, compositions and devices disclosed herein can be used for point-of-care treatment of a tissue injury or wound, e.g., in emergency care for first responders, emergency medical technicians (EMTs), ambulance workers, firemen, in field surgery, combat medicine or casualty care and/or first aid kits.
    Type: Application
    Filed: September 5, 2017
    Publication date: September 23, 2021
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Clifford J. Woolf, Ajay S. YEKKIRALA, Michael COSTIGAN
  • METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS
    Publication number: 20210186906
    Abstract: The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.
    Type: Application
    Filed: April 17, 2020
    Publication date: June 24, 2021
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf
  • Charged ion channel blockers and methods for use
    Patent number: 11021443
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: June 1, 2021
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf, Jinbo Lee, Sooyeon Jo, David Roberson, Sebastien Talbot
  • PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20210030695
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.
    Type: Application
    Filed: March 9, 2020
    Publication date: February 4, 2021
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Clifford J. Woolf, Bruce P. Bean
  • CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE
    Publication number: 20200377459
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation.
    Type: Application
    Filed: March 10, 2020
    Publication date: December 3, 2020
    Applicants: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf, Jinbo Lee, Sooyeon Jo, David P. Roberson, Sebastien Talbot
  • Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
    Patent number: 10729664
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: August 4, 2020
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Clifford J. Woolf, Bruce P. Bean
  • CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE THEREOF
    Publication number: 20200231545
    Abstract: The invention provides compounds, compositions, methods and kits for the treatment of pain, itch, and neurogenic inflammation.
    Type: Application
    Filed: January 3, 2020
    Publication date: July 23, 2020
    Applicants: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf, Jinbo Lee, Sooyeon Jo, Ivan Tochitsky
  • Devices and methods for analyzing animal behavior
    Patent number: 10650228
    Abstract: A device for detecting and recording animal behavior is provided. The device includes at least one corral that defines a contained field, the base surface of the at least one corral being sensitive to the animal's footprint. The device also includes an image capturing device that cooperates with the base surface to capture a first video frame in which at least one of a tail, body and head of the animal is illuminated by a light below the animal and a second video frame in which both a profile of a full footprint and a profile of a toe print of the animal when the animal is standing on its toes is illuminated by a light that is totally internally reflected within the base surface. A control system is arranged to control the image capturing device to capture the first and second video frames.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: May 12, 2020
    Assignees: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: David P. Roberson, Clifford J. Woolf, Michael T. Do, Alexander B. Wiltschko, Sandeep Robert Datta
  • Nucleic acids encoding hemojuvelin fusion proteins and uses thereof
    Patent number: 10611820
    Abstract: The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a HJV fusion protein to a patient in need thereof.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: April 7, 2020
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Herbert Y. Lin, Jodie Babitt, Clifford J. Woolf, Tarek A. Samad
  • DEVICES AND METHODS FOR ANALYZING RODENT BEHAVIOR
    Publication number: 20190261596
    Abstract: A device for detecting and recording animal behavior is provided. The device includes at least one corral that defines a contained field, the base surface of the at least one corral being sensitive to the animal's footprint. The device also includes an image capturing device that cooperates with the base surface to capture both a profile of the animal's full footprint and a profile of the animal's toe print when the animal is standing on its toes. In some embodiments, the device is capable of providing a stimulus to the animal and observing the resulting behavior of the animal via the image capturing device.
    Type: Application
    Filed: February 14, 2019
    Publication date: August 29, 2019
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Clifford J. Woolf, David P. Roberson, Alexander B. Wiltschko, Sandeep Robert Datta
  • Methods and assays relating to sepiapterin reductase inhibition
    Patent number: 10365267
    Abstract: Described herein are methods and assays relating to the inhibition of sepiapterin reductase and measuring said inhibition by measuring the level of sepiapterin. In some embodiments, the methods can further relate to treating a subject with BH4 and/or BH2.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: July 30, 2019
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Clifford J. Woolf, Alexandra S. Latini, Nick A. Andrews, Alban Latremoliere, Michael Costigan
  • PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20190216747
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.
    Type: Application
    Filed: December 11, 2018
    Publication date: July 18, 2019
    Inventors: Clifford J. WOOLF, Bruce P. BEAN
  • Methods to treat neurodegenerative diseases
    Patent number: 10350191
    Abstract: The specification provides compositions and methods to treat neurodegenerative diseases.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: July 16, 2019
    Assignees: Children's Medical Center Corporation, The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Clifford J. Woolf, Brian J. Wainger, Evangelos Kiskinis, Kevin Eggan
  • METHODS TO TREAT NEURODEGENERATIVE DISEASES
    Publication number: 20190125718
    Abstract: The specification provides compositions and methods to treat neurodegenerative diseases.
    Type: Application
    Filed: December 17, 2018
    Publication date: May 2, 2019
    Inventors: Clifford J. Woolf, Brian J. Wainger, Evangelos Kiskinis, Kevin Eggan