Abstract: This disclosure provides compositions and methods for delivering a viral composition to cells, e.g., for cell surface receptor-mediated uptake, and enhanced viral transduction. Viral transduction can be achieved via a modified viral composition that includes a moiety that binds to a cell surface receptor ligand. Modified viral compositions and methods for reducing levels or titers of neutralizing antibodies in a subject in need of viral therapy, e.g., gene therapy, are provided. In some embodiments, the modified viral composition includes empty viral particles that bind and internalize neutralizing autoantibodies. Modified viral compositions including empty viral particles can be administered prior to viral therapy. Also provided are pharmaceutical compositions and kits including a modified viral composition.

Abstract: This disclosure provides compositions and methods for delivering a viral composition to cells, e.g., for cell surface receptor-mediated uptake, and enhanced viral transduction. Viral transduction can be achieved via a bifunctional bridging composition that includes a moiety that binds to a cell surface receptor ligand and a linked bridging moiety that binds to a viral composition. Also provided are modified viral compositions comprising a bridging composition specifically bound via its bridging moiety to the viral composition. Modified viral compositions and methods for reducing levels or titers of neutralizing antibodies in a subject in need of viral therapy, e.g., gene therapy, are provided. In some embodiments, the modified viral composition includes empty viral particles that bind and internalize neutralizing autoantibodies. Modified viral compositions including empty viral particles can be administered prior to viral therapy.

Abstract: An electrically switchable optical modulator for modulating an optical wavefront transmitted therethrough, comprising a birefringent first optical element and a birefringent second optical element each having respective ordinary and extraordinary refractive indices. A birefringent liquid crystal material is sandwiched between the first and second optical elements. The extraordinary refractive index of the liquid crystal material is electrically switchable between: a first state in which it has a first value; and, a second state in which it has a second value different from the first value. One or both of the first value and the second value is un-matched to the extraordinary refractive index of the first optical element in respect of light polarised in a first direction of linear polarisation, and is un-matched to the extraordinary refractive index of the second optical element in respect of light polarised in a second direction of linear polarisation orthogonal to the first direction.

Abstract: An electrically switchable optical modulator for modulating an optical wavefront transmitted therethrough, comprising a birefringent first optical element and a birefringent second optical element each having respective ordinary and extraordinary refractive indices. A birefringent liquid crystal material is sandwiched between the first and second optical elements. The extraordinary refractive index of the liquid crystal material is electrically switchable between: a first state in which it has a first value; and, a second state in which it has a second value different from the first value. One or both of the first value and the second value is un-matched to the extraordinary refractive index of the first optical element in respect of light polarised in a first direction of linear polarisation, and is un-matched to the extraordinary refractive index of the second optical element in respect of light polarised in a second direction of linear polarisation orthogonal to the first direction.

Abstract: Disclosed is a dynamically switchable contact lens, operable to switch between first and second focal states, each focal state having a different optical property, the lens comprising: a power source; a controller, operable to control the operation of the lens; a transceiver operable to communicate with a second lens and/or an external controller; wherein the controller is operable to pair the lens with the second lens by means of the external controller.

Abstract: A game timer, suited in some embodiments as a chess clock, designed to calculate and display minimum average playing speed in moves per unit time over a sequence of one or more time controls based on input for number of moves in each time control, time allotted at the start of each time control, whether or not a delay applies to the moves of a particular time control, and time of the delay. In addition to these inputs, calculation of minimum average playing speed takes into consideration whether a delay comes before or after a move, whether or not a delay constitutes time available in the current time control, shortening of delays by players in the course of a game, and time remaining at the end of a time control. One embodiment estimates playing speed for “sudden death” over an entire game.

Abstract: A liquid crystal device (100) for focusing visible light, the liquid crystal device (100) comprising a plurality of curved substrates (101,102) arranged to form one or more curved cavities (104) therebetween, each substrate being configured to provide a focal power, wherein the one or more curved cavities contain liquid crystal and form one or more liquid crystal elements. Each of the one or more liquid crystal elements are configured to provide a focal power, the focal power of each of the liquid crystal elements being dependent on the curvature of the respective cavity and a voltage applied across the liquid crystal contained within the respective cavity. The substrates (101,102) in combination with the one or more liquid crystal elements are arranged to provide a first focal power in a substantial absence of an applied voltage and a second focal power in response to an applied voltage.

Abstract: A liquid crystal device (100) for focusing visible light, the liquid crystal device (100) comprising a plurality of curved substrates (101,102) arranged to form one or more curved cavities (104) therebetween, each substrate being configured to provide a focal power, wherein the one or more curved cavities contain liquid crystal and form one or more liquid crystal elements. Each of the one or more liquid crystal elements are configured to provide a focal power, the focal power of each of the liquid crystal elements being dependent on the curvature of the respective cavity and a voltage applied across the liquid crystal contained within the respective cavity. The substrates (101,102) in combination with the one or more liquid crystal elements are arranged to provide a first focal power in a substantial absence of an applied voltage and a second focal power in response to an applied voltage.

Abstract: The invention relates to a method of patterning a layer formed from a fixable material such as photopolymer on a surface in a desired pattern. The method involves coating selected areas of the substrate with an adhesion promoter and subsequently coating the fixable material. The fixable material is then fixed, for instance by curing by exposure to UV radiation. The adhesion promoter is adapted to have a surface energy which is designed to adhere to the substrate or selected areas thereof and also to the fixed material such that fixed material may be easily removed from areas of the substrate not coated with adhesion promoter but retained in areas where the adhesion promoter has bonded to the substrate.

Abstract: A display system 10 for displaying information at a point of product display in a retail outlet comprising a communicator 12 for transmitting display information to a remote display module 18, the display module 18 being adapted in a first, low power mode to display information and in a second, higher power mode periodically, in a predetermined manner, to communicate with the communicator 12, the system 10 preferably being configured to enable determination of the accuracy and automated correction of the synchronization of a periodic communication between the communicator 12 and the display module 18 while the display module 18 continues to switch between first and second modes of operation enabling a low overall consumption of power by the display module 18 and more preferably wherein the display module 18 is adapted to switch between first and second power modes between receipt of a synchronization signal and a display information signal from the communicator 12.

Abstract: The invention relates to a method of patterning a layer formed from a fixable material such as photopolymer on a surface in a desired pattern. The method involves coating selected areas of the substrate with an adhesion promoter and subsequently coating the fixable material. The fixable material is then fixed, for instance by curing by exposure to UV radiation. The adhesion promoter is adapted to have a surface energy which is designed to adhere to the substrate or selected areas thereof and also to the fixed material such that fixed material may be easily removed from areas of the substrate not coated with adhesion promoter but retained in areas where the adhesion promoter has bonded to the substrate.

Abstract: This invention relates to a liquid crystal device wherein the surface profile of a surface alignment grating stabilizes at least one stable state. The invention involves the introduction or breaks (34, 36, 38) or discontinuities into the grating (10) to divide the grating into a plurality of groove segments. The breaks are discontinuities in the grating in the groove direction, the grating having substantially the same groove direction on each side of the break. The introduction of breaks prevent free movement of defects along the groove of the grating and therefore help to stabilize the desired liquid crystal configuration, either a Defect state or a Continuous state. Suitable breaks involve gaps (34) in the groove ridges (30), necks (36) between the groove ridges (30) and slips or relative displacement (38) of the grating.

Abstract: Compounds of formula (I): which possess cell-cycle inhibitory activity are described.

Abstract: Compounds of formula (I): which possess cell-cycle inhibitory activity are described.

Abstract: A display system 10 for displaying information at a point of product display in a retail outlet comprising a communicator 12 for transmitting display information to a remote display module 18, the display module 18 being adapted in a first, low power mode to display information and in a second, higher power mode periodically, in a predetermined manner, to communicate with the communicator 12, the system 10 preferably being configured to enable determination of the accuracy and automated correction of the synchronisation of a periodic communication between the communicator 12 and the display module 18 while the display module 18 continues to switch between first and second modes of operation enabling a low overall consumption of power by the display module 18 and more preferably wherein the display module 18 is adapted to switch between first and second power modes between receipt of a synchronisation signal and a display information signal from the communicator 12.

Abstract: Compounds of formula (I): which possess cell-cycle inhibitory activity are described.

Abstract: The invention is directed to liquid crystal compositions for use in bistable liquid crystal devices and to bistable liquid crystal devices containing said liquid crystal compositions. The liquid crystal composition comprises a component (?) said component (?) containing one or more compounds having a phenyl ring of formula A Whereby XA is F, CI, SF5, NCS or a C1 to C8 alkanyl, alkenyl or alkoxy radical substituted with at least one F atom; and LA is H or F.

Abstract: Compounds of formula (I): which possess cell-cycle inhibitory activity are described.

Abstract: Compounds of the formula (I): wherein variable groups are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.

Abstract: In a liquid crystal device a substrate (1) favors at least two stable or metastable differently directed liquid crystal alignments, and switching means for causing the liquid crystal material to switch between the alignments includes means arranged for optically irradiating said device. The latter may provide linearly polarized light (3) for inducing a torque on the liquid crystal to determine the alignment direction, and may optionally cooperate with a second energy supplying means such as an electric field (V) for assisting and switching. Alternatively, the alignment of the liquid crystal may be switched by a second energy supplying means such as an electric field, the light serving to produce heat to aid the switching. Either or both energy sources may be applied locally for switching of selected areas or pixels. Energy levels at the bistable substrate may be adjusted by the use of an oligomeric additive (slippery surface).