Abstract: In silico tools are used to determine possibly effective therapies for treating a patient's cancer based on patient, drug, and cancer information. Functional assays can be performed on living cancer cells from the patient to evaluate the possibly effective therapies along with subsequent genomic or other more destructive assays to provide additional information from a single sample. Drug, patient, cancer, and outcome information can be recorded and updated iteratively and analyzed using machine learning to identify correlations between various patient, cancer, and drug characteristics and expected outcomes and drug efficacies.

Abstract: The invention provides methods that use machine learning to discover clinical data patterns that are predictive of disease, such as cancer. Clinical data from across a population is provided as input to a machine learning system. The machine learning system discovers associations in data from a plurality of data sources obtained from a population and correlates the associations to cancer status of patients in the population. The methods may further include providing patient data from an individual and predicting, by the machine learning system, a cancer state (e.g., the presence of cancer and a determination of a stage or progression of the cancer, if present) for the individual when the patient data presents one or more of the discovered associations.

Abstract: A game apparatus is provided and includes a magnetic pickup apparatus and a plurality of ferromagnetic game pieces. The magnetic pickup apparatus such as a wand has at least two spaced-apart game piece pickup regions wherein each pickup region incorporates a magnet having field strength differing than the field strength of the magnet associated with other pickup points. The magnetic pickup apparatus is capable of being manipulated by a user to magnetically pick up a ferromagnetic object using any one of the incorporated magnets. The ferromagnetic game pieces are provisioned having different colour, size and/or weight characteristics.

Abstract: Methods are provided for efficient shotgun sequencing to allow efficient selection and sequencing of nucleic acids of interest contained in a library. The nucleic acids of interest can be defined any time before or after preparation of the library. One example of nucleic acids of interest is missing or low confidence genome sequences resulting from an initial sequencing procedure. Other nucleic acids of interest include subsets of genomic DNA, RNA or cDNAs (exons, genes, gene sets, transciptomes). By designing an efficient (simple to implement, speedy, high specificity, low cost) selection procedure, a more complete sequence is achieved with less effort than by using highly redundant shotgun sequencing in an initial sequencing procedure.

Abstract: Methods are provided for efficient shotgun sequencing to allow efficient selection and sequencing of nucleic acids of interest contained in a library. The nucleic acids of interest can be defined any time before or after preparation of the library. One example of nucleic acids of interest is missing or low confidence genome sequences resulting from an initial sequencing procedure. Other nucleic acids of interest include subsets of genomic DNA, RNA or cDNAs (exons, genes, gene sets, transciptomes). By designing an efficient (simple to implement, speedy, high specificity, low cost) selection procedure, a more complete sequence is achieved with less effort than by using highly redundant shotgun sequencing in an initial sequencing procedure.

Abstract: The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods.

Abstract: A tensioner for a fencing wire reel, which includes a tensioning member, and a housing for the tensioning member, wherein the housing and the tensioning member are configured such that when fencing wire passes through the housing in one direction, the tensioning member applies a first biasing force against the wire, and when fencing wire passes through the housing in the opposite direction, the tensioning member applies a second biasing force against the wire, the second biasing force being less than the first biasing force. A portable fence system for constructing a fence, which includes at least one fencing wire reel, and a reel housing for the at least one fencing wire reel, and includes the tensioner as described is also claimed.

Abstract: An electric fence to span a given region between two substantially opposing supports, the fence including one or more insulators coupled to each opposing support; an electrical power source electrically connected to a first conductive strand and configured to apply an electrical current thereto, at least one further electrically distinct conductive strand coupled to the insulators and at a different electric potential than the first strand, characterised in that at least one insulator includes a substantially non-conductive element having one or more confined pathways, the element rotatable about a central axis orientated to maintain symmetrical revolution and wherein the conductive strands extend continuously and repeatedly between each support, each conductive strand in contact with at least one of the insulators.

Abstract: The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods.

Abstract: Methods are provided for efficient shotgun sequencing to allow efficient selection and sequencing of nucleic acids of interest contained in a library. The nucleic acids of interest can be defined any time before or after preparation of the library. One example of nucleic acids of interest is missing or low confidence genome sequences resulting from an initial sequencing procedure. Other nucleic acids of interest include subsets of genomic DNA, RNA or cDNAs (exons, genes, gene sets, transciptomes).

Abstract: The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods.

Abstract: A connection apparatus (1) is provided. The apparatus has: a body (7); at least two connectors (6a, 6b); and an interconnection element (16). The wire connectors (6a, 6b) connect wires to the apparatus (1) and provide a conductive connection of the wires to an interconnection element (16).

Abstract: A system for delivery of content over a wide area network, the content being captured by the system over a time period of a live event, the system comprising a first computer connected to a first side of the wide area network, the first computer having a cache for storing at least one data stream and the first computer having access to executable instruction code in an electronically readable medium.

Abstract: A fence device and method for constructing a fence support which comprises a sleeve for over a supporting member such as a rod extending vertically from a concrete base. The sleeve can be constructed of extruded insulating material and includes deformable internal projections to secure the sleeve by friction to the supporting member. The sleeve comprises at least one web or flange extending longitudinally and normally therefrom which has slots or incisions therein for a supporting lengths of material such as electrified wires. In one embodiment a pair of slots are disposed at opposing angles to facilitate securing lengths of wire.

Abstract: A fence support device and method for constructing a fence support which comprises a sleeve for fitting over a supporting member such as a rod extending vertically from a concrete base. The sleeve can be constructed of extruded insulating material and includes deformable internal projections to secure the sleeve by friction to the supporting member. The sleeve comprises at least one web or flange extending longitudinally and normally therefrom which has slots or incisions therein for a supporting lengths of material such as electrified wires. In one embodiment a pair of supporting means are slots disposed at opposing angles to facilitate securing lengths of wire.

Abstract: A system for delivery of content over a wide area network, the content being captured by the system over a time period of a live event, the system comprising a first computer connected to a first side of the wide area network, the first computer having a cache for storing at least one data stream and the first computer having access to executable instruction code in an electronically readable medium.