Abstract: The present invention relates, in part, to methods of preventing and/or treating a subject afflicted with bone loss conditions comprising administering to the subject a therapeutically effective amount of an agent that decreases the amount and/or activity of irisin.

Abstract: An arrangement for dynamic account allocation is achieved by pooling together spectrum and network availability, as well as congestion information, from different service providers in a central database and by the purchase of wholesale volume of network capacity or accounts with predetermined monthly usage. The purchased network capacity is dynamically allocated of devices of different origin and ownership. The central system operator administrates the rebilling and reconciliation of any fractional usage to each device.

Abstract: An arrangement for dynamic account allocation is achieved by pooling together spectrum and network availability, as well as congestion information, from different service providers in a central database and by the purchase of wholesale volume of network capacity or accounts with predetermined monthly usage. The purchased network capacity is dynamically allocated to devices of different origin and ownership. The central system operator administrates the rebilling and reconciliation of any fractional usage to each device. Unlike other proposed solutions that require the carriers to bet on proprietary technologies and involve changes to the network and high capital expenditures to build and operate the network, the present invention requires no changes to the carrier's network and no investment in a proprietary solution.