Abstract: Nucleoside analogues have structure (2) wherein Q is H or a sugar moiety or sugar analogue or a modified sugar or a nucleic backbone or backbone analogue, W is an alkylene or alkenylene chain of 0-5 carbon atoms, any of which may carry a substituent R8, X is O or N or NR12 or CR10, X′ is O or S or N, provided that when X′ is O or S, then X is C, Y is CH or N, R6 is NH2 or SMe or SO2Me or NHNH2, each of R7 and R8 is independently H or F or alkyl or alkenyl or aryl or acyl or a reporter moiety, R12 is independently H or alkyl or alkenyl or aryl or acyl or a reporter moiety, and R10 is H or ═O or F or alkyl or aryl or a reporter moiety.

Abstract: Nucleoside analogues or base analogues having structure (1), where X=O or NH or S, Y=N or CHR6 or CR6, W=N or NR6 or CHR6 or CR6 or S, n=1 or 2; each R6 is independently H or O or alkyl or alkenyl or alkoxy or aryl or a reporter moiety; where necessary (i.e. when Y and/or W is N or CR6 where R6 is not O) a double bond is present between Y and W or W and W, and Q is H or a sugar or a sugar analogue or a nucleic acid backbone or backbone analogue.

Abstract: Nucleotide or base analogues having structure (3) or (4) wherein X═O or NH or S and each R6 is independently H or alkyl or alkenyl or alkoxy or aryl or a reporter moiety.

Abstract: DNA and RNA diagnostics based on mass spectrometry, e.g. Matrix-Assisted Laser Desorption/Ionisation Time-of-Flight (MALDI-TOF) mass spectrometry, Electrospray (ES) mass spectrometry, Ion Cyclotron Resonance (ICR) mass spectrometry, Fourier Transform mass spectrometry, or combinations thereof, where fully or partially LNA modified DNA probes are used in order to enhance stability and resolution.

Abstract: Nucleoside analogues containing the degenerate base analogue P and derivatives thereof are provided with reporter moieties preferably comprising signal moieties. The nucleoside analogues are useful for labeling DNA or RNA or for incorporating in oligonucleotides.

Abstract: An improved processing technique results in a structure which maximizes contact area by eliminating a sidewall spacer used to form LDD regions. A sacrificial spacer is provided during processing to form the LDD regions, and is then removed prior to further processing of the device. A sidewall spacer is then formed in a self-aligned contact from a later deposited oxide layer used as an interlevel dielectric. This leaves only a single oxide sidewall spacer alongside the gate electrode, maximizing the surface area available for the self-aligned contact itself.

Abstract: Nucleoside analogues in which a group M replaces the natural base where M is (1) or (2) or (3), where each of X1, X2 and X3 are C or N, each of R6 and R7 is the same or different and each is H, NO2, CO, COR8, OR8, CN, O, CON(R8)2, COOR8, SO2R8, SO3R8, SR8, NHCHO, (CH2)n(R8)2, halogen, or a reporter moiety, each of R8 and R9 is H or hydrocarbyl or a reporter moiety, and n is 0-4. The analogues are substrates for polymerase and terminal transferase enzymes.

Abstract: Apparatus for scanning a light-beam across a sheet mounted on a flat bed, the apparatus including a bridge that extends across the bed from one side to the other and is supported at each end on carriage guided along a respective one of said sides of the bed, a scanning head that is su ported on the bridge, drive devices at each end of the bridge to drive a respective carriage, location devices at each end of the bridge to monitor the position of each carriage along a respective one of said sides, and control device to control operation of each drive devices in accordance with information of the position of the respective carriage driven by the drive devices, determined by the respective location devices, so that both ends of the bridge are moved simultaneously in timed relation to one another.

Abstract: A method is provided for forming a landing pad of a semiconductor integrated circuit, and an integrated circuit formed according to the same. A plurality of conductive regions are formed over a substrate. A polysilicon landing pad is formed over at least one of the plurality of conductive regions. After the polysilicon is patterned and etched to form the landing pad, tungsten is then selectively deposited over the polysilicon to form a composite polysilicon/tungsten landing pad which is a good etch stop, a good barrier to aluminum/silicon interdiffusion and a good conductor.

Abstract: An improved processing technique results in a structure which maximizes contact area by eliminating a sidewall spacer used to form LDD regions. A sacrificial spacer is provided during processing to form the LDD regions, and is then removed prior to further processing of the device. A sidewall spacer is then formed in a self-aligned contact from a later deposited oxide layer used as an interlevel dielectric. This leaves only a single oxide sidewall spacer alongside the gate electrode, maximizing the surface area available for the self-aligned contact itself.

Abstract: A glide head device for attachment to a flexure and for operation with a test system to detect a presence of asperities on a moving surface includes a slider constructed as a rigid body that is adapted to be suspended from the flexure and a transducer operatively associated with the slider. The slider's rigid body includes an air bearing surface operative to be oriented in facing relation to the moving surface when in an operative state and a sidewall margin area adjacent the trailing edge which is microfinished to a selected Ra value, such as 200 angstroms. A glide head assembly and a test device incorporating such a glide head device are also provided.

Abstract: A method is provided for forming a landing pad of a semiconductor integrated circuit, and an integrated circuit formed according to the same. A plurality of conductive regions are formed over a substrate. A polysilicon landing pad is formed over at least one of the plurality of conductive regions. After the polysilicon is patterned and etched to form the landing pad, tungsten is then selectively deposited over the polysilicon to form a composite polysilicon/tungsten landing pad which is a good etch stop, a good barrier to aluminum/silicon interdiffusion and a good conductor.

Abstract: A method is provided for forming a landing pad of a semiconductor integrated circuit, and an integrated circuit formed according to the same. A plurality of conductive regions are formed over a substrate. A polysilicon landing pad is formed over at least one of the plurality of conductive regions. After the polysilicon is patterned and etched to form the landing pad, tungsten is then selectively deposited over the polysilicon to form a composite polysilicon/tungsten landing pad which is a good etch stop, a good barrier to aluminum/silicon interdiffusion and a good conductor.

Abstract: A method is provided of making a dideoxynucleoside mono-or tri-phosphate, which is optionally 32-P or 33-P or 35-S radiolabelled which involves reacting the corresponding dideoxynucleoside with an optionally radiolabelled nucleotide phosphate or thiophosphate donor in the presence of a kinase of phosphotransferase enzyme which catalyses the reaction. A method of sequencing nucleic acids by a chain termination of a kinase or phosphotransferase enzyme which catalyses the reaction. A method of sequencing nucleic acids by a chain termination technique involves detecting the products of enzymatic synthesis by means of isotopically labelled chain terminating nucleotide analogues.

Abstract: A glide head assembly is associated with a support structure for use with a system for testing a moving surface to detect a presence of asperities thereon. This system includes signal processing operative to process an electronic signal generated in response to the presence of an asperity. The glide head assembly comprises a flexure adapted to be secured to the support structure and positionable in proximity to the moving surface. A slider is secured to a distal end portion of the flexure. A piezoelectric transducer is sandwiched partly between the slider and the distal end portion and preferably includes a free end portion which projects outwardly from this region to define a cantilever having a selected length and width. A test device for testing a moving surface on a rotating disk to determine a presence of asperities and a methodology for producing a glide head assembly for use with such a system are also provided.

Abstract: In a method for determining the dry matter content and nutritional value of moist vegetable material, such as silage, liquor is expressed from a sample of known quantity by applying thereto a reproducible pressure regime, the quantity of expressed liquor is measured, and the expressed liquor is analyzed for parameters, such as pH, ammonia, lactic acid, free sugar and alpha-amino nitrogen, from which the nutritional value can be estimated by regression. The nutritional value of silage can be expressed in terms of its fermentability in the rumen. The invention includes a portable facility for use in `on farm` analysis of silage to determine its nutritional value.