Abstract: The present invention provides compositions comprising an effective amount of xanthohumol and honokiol. The present invention comprises compositions comprising an effective amount of xanthohumol and genistein. The present invention comprises compositions comprising an effective amount of xanthohumol and guggulsterone. The compositions of the present invention may be effective to decrease mature adipocytes viability, induce apoptosis of mature adipocytes, increase lipolysis in mature adipocytes, and/or reduce adipogenesis during the maturation of pre-adipocytes. The present invention further provides methods of treating obesity, diabetes, osteoporosis or bone disorders in a subject, which comprise administering to the subject compositions comprising an effective amount of xanthohumol and honokiol, guggulsterone, or genistein.

Abstract: The present invention relates to naturally occurring compositions comprising vitamin D3 or related analog and methods for treating obesity and/or osteoporosis and reducing body fat or enhancing a bone graft in patients in need thereof.

Abstract: The present invention provides compositions comprising an effective amount of xanthohumol and honokiol. The present invention comprises compositions comprising an effective amount of xanthohumol and genistein. The present invention comprises compositions comprising an effective amount of xanthohumol and guggulsterone. The compositions of the present invention may be effective to decrease mature adipocytes viability, induce apoptosis of mature adipocytes, increase lipolysis in mature adipocytes, and/or reduce adipogenesis during the maturation of pre-adipocytes. The present invention further provides methods of treating obesity, diabetes, osteoporosis or bone disorders in a subject, which comprise administering to the subject compositions comprising an effective amount of xanthohumol and honokiol, guggulsterone, or genistein.

Abstract: Pharmaceutical compositions, methods for increasing the rate of apoptosis in adipose tissue cells, and methods of reducing adipose tissue mass in a host, are described. One exemplary pharmaceutical composition, among others, includes at least one catecholamine in combination with a pharmaceutically acceptable carrier. The catecholamine is present in a dosage level effective to increase the rate of apoptosis in adipose tissue cells in a host.

Abstract: Delivery devices which include a beneficial agent and an activating mechanism in separate compartments separated by a moveable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a band of resilient material which is placed over the orifice. The resilient material is sufficiently tight to substantially seal the orifice when the pressure within the device is below a threshold level while at the same time being capable of being stretched when the internal pressure exceeds the threshold.

Abstract: Alleviation of stomach ulcers in swine which are being administered exogenous somatotropin, by administering to the swine a benzimidazole compound selected from heterocyclylalkyl(sulfinyl or thio)benzimidazoles and [benzimidazolyl(sulfinyl or thio)alkyl]anilines.

Abstract: Delivery devices which include a beneficial agent and an activating mechanism in separate compartments separated by a moveable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a band of resilient material which is placed over the orifice. The resilient material is sufficiently tight to substantially seal the orifice when the pressure within the device is below a threshold level while at the same time being capable of being stretched when the internal pressure exceeds the threshold.

Abstract: Osmotically driven delivery capsules which include a beneficial agent and a water absorptive osmotic engine in separate compartments separated by a movable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a series of stops along the inner wall of the capsule which obstruct the movement of the partition but which are overcome in succession as the osmotic pressure rises above a threshold level. The number of stops and their placement longitudinally along the length of the capsule establish the number and frequency of the pulses, and the configuration of the partition controls the pulse intensity.

Abstract: Compositions and methods for inducing polyphagia or eating in meat producing animals comprise administering orally or preferably by injection an effective but nontoxic subpharmacodynamic quantity of a benzhydryl ether active ingredient. Preferred active ingredients are tropine benzohydryl ether, 3-quinuclidinyl benzohydryl ether or their nontoxic acid addition salts.

Abstract: New methods and compositions for inducing polyphagia in growing or fattening meat producing animals such as sheep or cattle are described using as active ingredients certain carbamates, ureas, oxyureas or ureides. The active ingredients are used most usefully at subhypnotic quantities admixed in animal feed.

Abstract: 8-Alkyl and alkenyl-10-hydroxy-5H[1]benzopyranopyridines are prepared by dehydrogenation of the corresponding N-benzyl or N-hydrogen-8-alkyl or alkenyl-1,2,3,4-tetrahydro-5H[1]benzopyranopyridines in a high boiling solvent in the presence of a noble metal dehydrogenation catalyst. Alkyl derivatives of 5-11 carbon atoms are particularly useful. Also the O-acetyl derivatives are very useful. The compounds are central nervous system depressants and animal polyphagic agents.

Abstract: Methods and compositions utilizing certain local anesthetic derivatives which increase growth rate and feed efficiency of animals, particularly ruminants. The preferred compounds to be used as active ingredients are local anesthetics, such as, for example, mepivacaine hydrochloride, bupivacaine hydrochloride, tetracaine hydrochloride, and oxethazainechloro hydrochloride.

Abstract: Compositions and methods for inducing polyphagia in immature meat producing animals comprise administering orally or by injection an effective but nontoxic subpharmacodynamic quantity of a 1,4-benzodiazepinone active ingredient whose structure is characterized by an 1-alkyl-sulfonylalkyl moiety. Preferred active ingredients are 1-(ethylsulfonylethyl)-5-(o-halophenyl)-7-halo-1,3-dihydro-2H-1,4-benzodia zepin-2-ones.

Abstract: New methods and compositions for inducing polyphagia in growing or fattening meat producing animals such as sheep or cattle are described using as active ingredients tertiary alcohols or the corresponding carbamates, ureas, oxyureas or ureides. The active ingredients are used most usefully at sub-hypnotic quantities admixed in animal feed.