Patents by Inventor Clifton E. Barry

Clifton E. Barry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nitroimidazole Compounds
    Publication number: 20080275035
    Abstract: The present invention relates to certain nitroimidazole compounds, which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Mycobacterium tuberculosis, Trypanosoma cruzi or Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.
    Type: Application
    Filed: December 22, 2006
    Publication date: November 6, 2008
    Inventors: Jan Jiricek, Sejal Patel, Thomas Hugo Keller, Clifton E. Barry, Cynthia S. Dowd
  • Anti tubercular drug: compositions and methods
    Publication number: 20040033986
    Abstract: Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
    Type: Application
    Filed: May 16, 2003
    Publication date: February 19, 2004
    Inventors: Marina Nikolaevna Protopopova, Richard Edward Lee, Richard Allan Slayden, Clifton E. Barry, Elena Bogatcheva, Leo Einck
  • Anti tubercular drug: compostions and methods
    Publication number: 20040019117
    Abstract: Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
    Type: Application
    Filed: May 19, 2003
    Publication date: January 29, 2004
    Inventors: Marina Nikolaevna Protopopova, Richard Edward Lee, Richard Allan Slayden, Clifton E. Barry, Elena Bogatcheva, Leo Einck
  • Methods of use and compositions for the diagnosis and treatment of infectious disease
    Publication number: 20030236225
    Abstract: Methods and compositions for treating disease caused by microorganisms, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
    Type: Application
    Filed: May 17, 2002
    Publication date: December 25, 2003
    Inventors: Marina Nikolaevna Protopopova, Richard Edward Lee, Richard Allan Slayden, Clifton E. Barry
  • Methods of diagnosing multidrug resistant tuberculosis
    Publication number: 20030013090
    Abstract: The invention relates to the discovery that a putative gene of Mycobacterium tuberculosis with no previously identified function is responsible for the ability of the bacterium to activate thioamide drugs. Since M. tuberculosis has a low rate of synonymous mutations, all mutations in this gene, identified as Rv3854c and now termed “EtaA,” are expected to inhibit the ability of a bacterium with the mutation to activate a thioamide or thiocarbonyl drug. Thus, detecting a bacterium with a mutation in this gene indicates that the bacterium is resistant to treatment with thioamides.
    Type: Application
    Filed: June 22, 2001
    Publication date: January 16, 2003
    Inventors: Clifton E. Barry, Andrea E. DeBarber, Khisimuzi Mdluli, Linda-Gail Bekker