Patents by Inventor Clinton H. Hansen

Clinton H. Hansen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FORCE-CONTROLLED NANOSWITCH ASSAYS FOR SINGLE-MOLECULE DETECTION IN COMPLEX BIOLOGICAL FLUIDS
    Publication number: 20240076715
    Abstract: Provided herein are methods and products for detecting analytes in a sample. The analytes may be rare analytes such as biomarkers in a biological sample. These methods make use of nucleic acid nanoswitches that adopt a particular conformation and have a particular length in the presence of an analyte.
    Type: Application
    Filed: February 13, 2023
    Publication date: March 7, 2024
    Applicant: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Johanna Blass, Darren Yang, Clinton H. Hansen
  • METHOD FOR DETECTION OF ANALYTES VIA POLYMER COMPLEXES
    Publication number: 20240018577
    Abstract: Provided herein are products and methods for detecting analytes using polymers that bind to such analytes and thereby undergo a conformational change or contribute to a newly formed complex.
    Type: Application
    Filed: June 26, 2023
    Publication date: January 18, 2024
    Applicant: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Clinton H. Hansen
  • SYSTEMS AND METHODS FOR HIGH THROUGHPUT SCREENING OF MOLECULAR INTERACTIONS
    Publication number: 20230407374
    Abstract: This disclosure provides new and improved systems and methods for analyzing binding interactions and for identifying and measuring agents that modulate such binding interactions, including weak binding interactions. The methods may be used in high throughput screening assays.
    Type: Application
    Filed: November 9, 2021
    Publication date: December 21, 2023
    Applicant: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Clinton H. Hansen
  • Method for detection of analytes via polymer complexes
    Patent number: 11713483
    Abstract: Provided herein are products and methods for detecting analytes using polymers that bind to such analytes and thereby undergo a conformational change or contribute to a newly formed complex.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: August 1, 2023
    Assignee: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Clinton H. Hansen
  • Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids
    Patent number: 11591636
    Abstract: Provided herein are methods and products for detecting analytes in a sample. The analytes may be rare analytes such as biomarkers in a biological sample. These methods make use of nucleic acid nanoswitches that adopt a particular conformation and have a particular length in the presence of an analyte.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: February 28, 2023
    Assignee: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Johanna Blass, Darren Yang, Clinton H. Hansen
  • NUCLEIC ACID COMPLEXES FOR SCREENING BARCODED COMPOUNDS
    Publication number: 20230045556
    Abstract: The invention provides compositions comprising nucleic acid complexes for use in screening compounds based on their ability to modulate binding interactions, wherein the compounds are barcoded.
    Type: Application
    Filed: June 21, 2022
    Publication date: February 9, 2023
    Applicant: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Clinton H. Hansen
  • Nucleic acid complexes for screening barcoded compounds
    Patent number: 11396650
    Abstract: The invention provides compositions comprising nucleic acid complexes for use in screening compounds based on their ability to modulate binding interactions, wherein the compounds are barcoded.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: July 26, 2022
    Assignee: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Clinton H. Hansen
  • Systems and apparatus for detecting compounds in human biological samples
    Patent number: 10919037
    Abstract: Systems and apparatus for performing analysis of human biological samples are described. Collected biological samples are combined with a substance including nucleic acid complexes and the combined substance is processed using gel electrophoresis. An indication of a detected compound in the biological sample and/or a particular medical condition associated with the detected compound is output from the apparatus.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: February 16, 2021
    Assignee: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Clinton H. Hansen, Mounir Ahmad Koussa
  • FORCE-CONTROLLED NANOSWITCH ASSAYS FOR SINGLE-MOLECULE DETECTION IN COMPLEX BIOLOGICAL FLUIDS
    Publication number: 20200340033
    Abstract: Provided herein are methods and products for detecting analytes in a sample. The analytes may be rare analytes such as biomarkers in a biological sample. These methods make use of nucleic acid nanoswitches that adopt a particular conformation and have a particular length in the presence of an analyte.
    Type: Application
    Filed: November 20, 2018
    Publication date: October 29, 2020
    Applicant: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Johanna Blass, Darren Yang, Clinton H. Hansen
  • RAPID AND SENSITIVE DETECTION AND QUANTIFICATION OF ANALYTES IN COMPLEX SAMPLES USING POLYMER-BASED METHODS
    Publication number: 20200116712
    Abstract: Provided herein, inter alia, are improved methods for detecting analytes, including proteins and nucleic acids. In some instances, the analytes are detected in complex matrices such as serum.
    Type: Application
    Filed: March 23, 2017
    Publication date: April 16, 2020
    Applicant: Children's Medical Center Corporation
    Inventors: Clinton H. Hansen, Wesley Philip Wong, Darren Yang, Andrew Ward
  • NUCLEIC ACID NANOSWITCH CONSTRUCTION METHODS
    Publication number: 20190345193
    Abstract: This disclosure provides methods for generating functionalized nanoswitches, as well as the functionalized nanoswitches themselves, and methods of use thereof.
    Type: Application
    Filed: December 5, 2017
    Publication date: November 14, 2019
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Darren Yang, Eric M. Mulhall, Hongyu Zhao, Andrew Ward, Clinton H. Hansen, Wesley Philip Wong
  • SYSTEMS AND APPARATUS FOR DETECTING COMPOUNDS IN HUMAN BIOLOGICAL SAMPLES
    Publication number: 20190070604
    Abstract: Systems and apparatus for performing analysis of human biological samples are described. Collected biological samples are combined with a substance including nucleic acid complexes and the combined substance is processed using gel electrophoresis. An indication of a detected compound in the biological sample and/or a particular medical condition associated with the detected compound is output from the apparatus.
    Type: Application
    Filed: March 23, 2017
    Publication date: March 7, 2019
    Applicant: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Clinton H Hansen, Mounir Ahmad Koussa
  • METHOD FOR DETECTION OF ANALYTES VIA POLYMER COMPLEXES
    Publication number: 20190048409
    Abstract: Provided herein are products and methods for detecting analytes using polymers that bind to such analytes and thereby undergo a conformational change or contribute to a newly formed complex.
    Type: Application
    Filed: February 8, 2017
    Publication date: February 14, 2019
    Applicant: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Clinton H. Hansen
  • COMPOSITIONS AND METHODS FOR ANALYTE DETECTION USING NANOSWITCHES
    Publication number: 20180223344
    Abstract: Provided herein are nucleic acid-based nanoswitches that can detect specific nucleic acids and other analytes types by for example a simple gel electrophoresis readout. Binding of the target to the nanoswitches induces a conformation change from a linear, open conformation to a looped, closed conformation. These nanoswitches may be used in diagnostic assays such as nucleic acid-based diagnostic assays, to detect, measure and/or purify a variety of targets including low abundance targets.
    Type: Application
    Filed: June 27, 2016
    Publication date: August 9, 2018
    Inventors: Arun Richard Chandrasekaran, Clinton H. Hansen, Mounir Ahmad Koussa, Kenneth Anders Halvorsen, Wesley Philip Wong
  • NUCLEIC ACID COMPLEXES FOR SCREENING BARCODED COMPOUNDS
    Publication number: 20180135043
    Abstract: The invention provides compositions comprising nucleic acid complexes for use in screening compounds based on their ability to modulate binding interactions, wherein the compounds are barcoded.
    Type: Application
    Filed: June 2, 2016
    Publication date: May 17, 2018
    Applicant: Children's Medical Center Corporation
    Inventors: Wesley Philip Wong, Clinton H. Hansen