Patents by Inventor Clinton Rubin
Clinton Rubin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11918822Abstract: The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.Type: GrantFiled: October 19, 2022Date of Patent: March 5, 2024Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILLInventors: Clinton Rubin, Janet Rubin
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Publication number: 20230173292Abstract: The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.Type: ApplicationFiled: October 19, 2022Publication date: June 8, 2023Inventors: Clinton Rubin, Janet Rubin
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Publication number: 20210393972Abstract: The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.Type: ApplicationFiled: June 22, 2021Publication date: December 23, 2021Inventors: Clinton Rubin, Janet Rubin
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Patent number: 11040215Abstract: The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.Type: GrantFiled: July 20, 2018Date of Patent: June 22, 2021Assignee: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS). U.S. GOVERNMENT NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR)Inventors: Clinton Rubin, Janet Rubin
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Patent number: 10632041Abstract: A vibration device 10 includes top plate assembly 12 defining cavity 27 therein that is configured and dimensioned to receive actuator plate 19 such that the actuator plate 19 is in direct contact with the top plate assembly 12. The actuator plate 19 transmits thereby a vibration signal represented by an oscillating vibratory force to the top plate assembly 12 to operate the oscillating vibration device. Vibration device 10 further includes base plate assembly 14 for the vibration device 10. The top plate assembly 12 is configured and dimensioned to be mounted on the base plate assembly 14. The base plate assembly 14 includes actuator mounting assembly 20 that is configured to receive actuator 50 generating a vibration signal represented by an oscillating vibratory force. A method of operating the oscillating vibration device 10 includes transmitting a vibration signal represented by an oscillating vibratory force to foot plate assembly 12.Type: GrantFiled: January 22, 2014Date of Patent: April 28, 2020Assignee: Marodyne Medical, LLCInventor: Clinton Rubin
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Publication number: 20190030317Abstract: The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.Type: ApplicationFiled: July 20, 2018Publication date: January 31, 2019Inventors: Clinton RUBIN, Janet RUBIN
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Patent number: 10029089Abstract: The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.Type: GrantFiled: October 14, 2011Date of Patent: July 24, 2018Assignees: RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE, NORTH CAROLINA AT CHAPEL HILL, UNIVERSITY OFInventors: Clinton Rubin, Janet Rubin
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Publication number: 20170348174Abstract: Methods and systems of applying physical stimuli to tissue are disclosed. The methods can include reducing or suppressing pancreatitis in a subject by administering a low magnitude, high frequency mechanical signal on a period basis and for a time sufficient to reduce or suppress pancreatitis. The methods can include enhancing healing of damaged tissue in a subject by administering to the subject a low magnitude, high frequency mechanical signal on a periodic basis and for a time sufficient to treat the damaged tissue. The systems can include a device for generating a low magnitude, high frequency physical signal and a platform for applying the low magnitude, high frequency physical signal to the subject for a predetermined time.Type: ApplicationFiled: August 22, 2017Publication date: December 7, 2017Inventors: Clinton Rubin, Stefan Judex, Timothy J. Koh, Giamila Fantuzzi
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Publication number: 20170007485Abstract: Methods and systems of applying physical stimuli to tissue are disclosed. The methods can include reducing or suppressing pancreatitis in a subject by administering a low magnitude, high frequency mechanical signal on a period basis and for a time sufficient to reduce or suppress pancreatitis. The methods can include enhancing healing of damaged tissue in a subject by administering to the subject a low magnitude, high frequency mechanical signal on a periodic basis and for a time sufficient to treat the damaged tissue. The systems can include a device for generating a low magnitude, high frequency physical signal and a platform for applying the low magnitude, high frequency physical signal to the subject for a predetermined time.Type: ApplicationFiled: September 22, 2016Publication date: January 12, 2017Inventors: Clinton Rubin, Stefan Judex, Timothy J. Koh, Giamila Fantuzzi
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Publication number: 20160101016Abstract: Methods and systems of applying physical stimuli to tissue are disclosed. The methods can include reducing or suppressing pancreatitis in a subject by administering a low magnitude, high frequency mechanical signal on a period basis and for a time sufficient to reduce or suppress pancreatitis. The methods can include enhancing healing of damaged tissue in a subject by administering to the subject a low magnitude, high frequency mechanical signal on a periodic basis and for a time sufficient to treat the damaged tissue. The systems can include a device for generating a low magnitude, high frequency physical signal and a platform for applying the low magnitude, high frequency physical signal to the subject for a predetermined time.Type: ApplicationFiled: December 15, 2015Publication date: April 14, 2016Inventors: Clinton Rubin, Stefan Judex, Timothy J. Koh, Giamila Fantuzzi
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Publication number: 20150359702Abstract: A vibration device 10 includes top plate assembly 12 defining cavity 27 therein that is configured and dimensioned to receive actuator plate 19 such that the actuator plate 19 is in direct contact with the top plate assembly 12. The actuator plate 19 transmits thereby a vibration signal represented by an oscillating vibratory force to the top plate assembly 12 to operate the oscillating vibration device. Vibration device 10 further includes base plate assembly 14 for the vibration device 10. The top plate assembly 12 is configured and dimensioned to be mounted on the base plate assembly 14. The base plate assembly 14 includes actuator mounting assembly 20 that is configured to receive actuator 50 generating a vibration signal represented by an oscillating vibratory force. A method of operating the oscillating vibration device 10 includes transmitting a vibration signal represented by an oscillating vibratory force to foot plate assembly 12.Type: ApplicationFiled: January 22, 2014Publication date: December 17, 2015Inventor: Clinton Rubin
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Publication number: 20130288260Abstract: The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.Type: ApplicationFiled: October 14, 2011Publication date: October 31, 2013Applicant: The Research Foundation of State University of New YorkInventors: Clinton Rubin, Janet Rubin
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Publication number: 20110070206Abstract: We describe herein methods for applying physical stimuli to cells, including mesenchymal stem cells, in culture or in vivo. These methods can be applied in, and are expected to benefit subjects in, a great variety of circumstances that arise in the context of, for example, traumatic injury (including that induced by surgical procedures), wound healing (of the skin and other tissues), cancer therapies (e.g., chemotherapy or radiation therapy), tissue transplantation (e.g., bone marrow transplantation), and aging. More generally, the present methods apply where patients would benefit from an increase in the number of cells (e.g., stem cells) within a given tissue and, ex vivo, where it is desirable to increase the proliferation of cells (e.g., stem cells) for scientific study, inclusion in devices bearing cells (e.g., polymer or hydrogel-based implants), and administration to patients.Type: ApplicationFiled: March 2, 2009Publication date: March 24, 2011Applicant: The Research Foundation of State University Of New YorkInventors: Clinton Rubin, Stefan Judex, Yen Kim Luu
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Patent number: 7727152Abstract: The invention comprises a system and method for determining at least one material property of a material sample (such as a bone sample) at at least one point. The system includes a transmitting ultrasonic transducer and a receiving ultrasonic transducer, both transducers being confocal transducers. The transducers are configured to receive the material sample therebetween such that the confocal point of the transducers are located at the at least one point in the material sample. A processor initiates an ultrasonic signal from the transmitting transducers that is transmitted trough the at least one point of the material sample when positioned between the transducers. The ultrasonic signal is received by the receiving transducing and the processor in turn receives a signal reflecting one or more measures of the received ultrasonic signal. The processor determines at least one ultrasonic parameter for the at least one point of the material sample based upon the transmitted and received ultrasonic signals.Type: GrantFiled: February 28, 2002Date of Patent: June 1, 2010Assignee: The Research Foundation of State University of New YorkInventors: Yixian Qin, Clinton Rubin, Wei Lin
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Publication number: 20100028968Abstract: Methods of maintaining or improving the metabolic state of a subject, e.g., a human, are disclosed. The methods can include providing to the subject a low magnitude, high frequency mechanical signal on a periodic basis and for a time sufficient to maintain or improve the subject's metabolic state. The subject can be diagnosed as having or can be at risk of developing, an obesity-related medical condition, e.g., type 2 diabetes, cardiovascular disease, hypertension, rheumatoid arthritis, and breast cancer. The methods can include a step of identifying a suitable subject by evaluating a physiological parameter that reflects the metabolic state of the subject, e.g., visceral fat content, subcutaneous fat content, body mass index, and blood pressure.Type: ApplicationFiled: May 17, 2007Publication date: February 4, 2010Inventors: Clinton Rubin, Stefan Judex, Jeff Pessin
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Publication number: 20070219470Abstract: Systems and methods are disclosed for providing therapeutic treatment using vibrational stimulation, ultrasound stimulation and electro-stimulation. The combined therapeutic treatment allows for more flexible and effective treatment of bone-loss related and other ailments and conditions by providing one or a combination of vibrational, ultrasound and/or electro-stimulation to a patient.Type: ApplicationFiled: March 8, 2007Publication date: September 20, 2007Inventors: Roger Talish, Clinton Rubin, Kenneth McLeod
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Publication number: 20070219473Abstract: A non-invasive apparatus for dynamic motion therapy in a weightless environment include a vibration table having a non-rigidly supported platform for generating resonant vibration and for externally transferring vibrations to the musculoskeletal system, and ankle belts or other securing means to secure a person to the vibration table. The method of providing dynamic motion therapy to a person in a weightless environment includes the steps of (a) providing a vibration table having a non-rigidly supported platform; (b) securing the person to the non-rigidly supported platform; (c) subjecting the person to resonant vibrations generated by the non-rigidly supported platform; and (d) repeating steps (b) and (c) during a predetermined treatment duration. The predetermined treatment duration is at least the duration of the weightless environment.Type: ApplicationFiled: March 7, 2007Publication date: September 20, 2007Inventors: Roger Talish, Clinton Rubin
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Publication number: 20070185419Abstract: A therapeutic device, such as an exercise device, includes the principles of osteogenic repair by incorporating a loading mechanism into the exercise device. By doing so, the therapeutic device provides an increased osteogenic effect, thereby enhancing the benefits of the therapy. As an example, a exercise device includes a support surface for supporting all or part of the bodily tissue of an individual using the device. A linear or rotary loading mechanism associated with the frame or a rotational element of the exercise device drives the support surface at a selected load and frequency, thereby inducing mechanical loading of bodily tissue adjacent to the support surface sufficiently to facilitate the growth, development, strengthening, and/or healing of bone tissue. The loading mechanism may be incorporated into any exercise device, including standard exercise devices such as rowing machines, stair climbing machines, elliptical trainers, bicycles, cross-country ski trainers, treadmills, or weight trainers.Type: ApplicationFiled: March 14, 2007Publication date: August 9, 2007Inventors: Roger Talish, Kenneth McLeod, Clinton Rubin
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Publication number: 20050283072Abstract: The invention comprises a system and method for determining at least one material property of a material sample (such as a bone sample) at at least one point. The system includes a transmitting ultrasonic transducer and a receiving ultrasonic transducer, both transducers being confocal transducers. The transducers are configured to receive the material sample therebetween such that the confocal point of the transducers are located at the at least one point in the material sample. A processor initiates an ultrasonic signal from the transmitting transducers that is transmitted trough the at least one point of the material sample when positioned between the transducers. The ultrasonic signal is received by the receiving transducing and the processor in turn receives a signal reflecting one or more measures of the received ultrasonic signal. The processor determines at least one ultrasonic parameter for the at least one point of the material sample based upon the transmitted and received ultrasonic signals.Type: ApplicationFiled: February 28, 2002Publication date: December 22, 2005Inventors: Yixian Qin, Clinton Rubin, Wei Lin
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Publication number: 20050165332Abstract: A therapeutic device, such as an exercise device, includes the principles of osteogenic repair by incorporating a loading mechanism into the exercise device. By doing so, the therapeutic device provides an increased osteogenic effect, thereby enhancing the benefits of the therapy. As an example, a exercise device includes a support surface for supporting all or part of the bodily tissue of an individual using the device. A linear or rotary loading mechanism associated with the frame or a rotational element of the exercise device drives the support surface at a selected load and frequency, thereby inducing mechanical loading of bodily tissue adjacent to the support surface sufficiently to facilitate the growth, development, strengthening, and/or healing of bone tissue. The loading mechanism may be incorporated into any exercise device, including standard exercise devices such as rowing machines, stair climbing machines, elliptical trainers, bicycles, cross-country ski trainers, treadmills, or weight trainers.Type: ApplicationFiled: March 23, 2005Publication date: July 28, 2005Inventors: Roger Talish, Kenneth McLeod, Clinton Rubin