Abstract: One aspect of the invention provides a computer-implemented method of identifying one or more clinical factors associated with an artificial intelligence prediction. The computer implemented method includes: applying a previously trained deep neural network to one or more images for a subject to produce a prediction, the previously trained deep neural network comprising a plurality of nodes; comparing outputs of the nodes to previously identified patterns of node outputs for a plurality of individual clinical factors; and identifying which of the plurality of individual clinical factors are most correlated with the outputs of the nodes.