Patents by Inventor Clinton Yu

Clinton Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL CLASS OF TRIOXANE-BASED MS-CLEAVABLE CROSS-LINKERS TO ADVANCE PROTEIN-PROTEIN INTERACTION STUDIES USING CROSS-LINKING MASS SPECTROMETRY
    Publication number: 20250389728
    Abstract: The disclosure provides for mass spectrometry (MS)-cleavable trioxane-based cross-linkers, and uses thereof, including for protein-protein interaction studies using cross-linking mass spectrometry.
    Type: Application
    Filed: June 9, 2025
    Publication date: December 25, 2025
    Inventors: Lan Huang, Scott D. Rychnovsky, Eric J. Novitsky, Clinton Yu
  • Mass spectrometry-cleavable cross-linker
    Patent number: 10697977
    Abstract: Provided herein is synthesis of a novel acidic acid residue targeting sulfoxide-containing MS-cleavable homobifunctional cross-linker. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes. Also disclosed herein are data based on the novel MS-cleavable homobifunctional cross-linker that are complimentary to amine-reactive sulfoxide-containing MS-cleavable reagents.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: June 30, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Lan Huang, Scott D. Rychnovsky, Clinton Yu, Eric James Novitsky, Craig Bryant Gutierrez
  • MASS SPECTROMETRY-CLEAVABLE CROSS-LINKER
    Publication number: 20170350901
    Abstract: Provided herein is synthesis of a novel acidic acid residue targeting sulfoxide-containing MS-cleavable homobifunctional cross-linker. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes. Also disclosed herein are data based on the novel MS-cleavable homobifunctional cross-linker that are complimentary to amine-reactive sulfoxide-containing MS-cleavable reagents.
    Type: Application
    Filed: June 2, 2017
    Publication date: December 7, 2017
    Inventors: Lan Huang, Scott D. Rychnovsky, Clinton Yu, Eric James Novitsky, Craig Bryant Gutierrez