Patents by Inventor Cliona Stapleton

Cliona Stapleton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of L-amino acids with amplification of the zwf gene
    Publication number: 20050112733
    Abstract: The invention relates to a process for the preparation of L-amino acids. The process involves fermenting an L-amino acid producing coryneform bacteria in a culture medium, concentrating L-amino acid in the culture medium or in the cells of the bacteria, and isolating the L-amino acid produced. The bacteria has an amplified gene encoding the Zwischenferment protein.
    Type: Application
    Filed: December 30, 2004
    Publication date: May 26, 2005
    Inventors: Kevin Burke, Hermann Sahm, Lothar Eggeling, Bernd Moritz, L. Dunican, Ashling McCormack, Cliona Stapleton, Bettina Mockel, Georg Thierbach, Rita Dunican
  • Process for the preparation of L-amino acids using a gene encoding 6-phosphogluconate dehydrogenase
    Publication number: 20040063181
    Abstract: The invention relates to a process for the preparation of L-amino acids. The process involves fermenting an L-amino acid producing coryneform bacteria in a culture medium, concentrating L-amino acid produced by the fermenting in the culture medium or in the cells of the bacteria, and isolating the L-amino acid produced. The bacteria has an overexpressed gene encoding 6-phosphogluconate dehydrogenase and a decreased or switched off gene encoding pyruvate oxidase. The L-amino acid may be L-lysine, L-threonine, L-isoleucine or L-tryptophan.
    Type: Application
    Filed: October 17, 2003
    Publication date: April 1, 2004
    Applicants: Degussa-Huls Aktiengasellschaft, National University of Ireland
    Inventors: L. K. Duncan, Ashling McCormack, Cliona Stapleton, Kevin Burke, Bettina Mockel
  • Nucleotide sequences which code for the opcA gene
    Publication number: 20030138917
    Abstract: The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
    Type: Application
    Filed: May 3, 2002
    Publication date: July 24, 2003
    Inventors: L. K. Dunican, Rita Dunican, Ashling McCormack, Cliona Stapleton, Kevin Burke, Bernd S. Moritz, Lothar Eggeling, Hermann Sahm, Bettina Mockel, Anke Weissenborn
  • Method for increasing the metabolic flux through the pentose phosphate cycle in coryneform bacteria by regulation of the phosphoglucose isomerase (pgi gene)
    Patent number: 6586214
    Abstract: The present invention is directed to isolated polynucleotides coding for phosphoglucose isomerase (pgi) from coryneform bacteria. In addition, the invention includes methods for increasing the metabolic flux through pentose phosphate cycle of bacteria by reducing or eliminating the activity of pgi. These methods may be used to increase the fermentative production of nucleotides, vitamins and amino acids.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: July 1, 2003
    Assignee: Degussa AG
    Inventors: L. K. Dunican, Ashling McCormack, Cliona Stapleton, Kevin Burke, Michael O'Donohue, Achim Marx, Bettina Mockel
  • Process for the fermentative preparation of L-amino acids with amplification of the tkt gene
    Publication number: 20030109014
    Abstract: The invention relates to a process for the preparation of L-amino acids by the fermentation of coryneform bacteria that over-express a gene encoding transketolase.
    Type: Application
    Filed: May 14, 2002
    Publication date: June 12, 2003
    Inventors: Kevin Burke, L. K. Dunican, Rita Duncian, Ashling McCormack, Cliona Stapleton, Bettina Mockel, Georg Thierbach