Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

Abstract: Disclosed is an enabling assembly which may be used for a variety of purposes, including walls, room partitions, signs, arched supports, game boards and puzzles, the assembly including a plurality of interlocking pillow elements surrounded by a frame and mounting a plurality of facing elements in a manner enabling the facing elements, if not fixed, to be shifted so as to change the patterns thereon, the facing elements each having a connecting shaft disposed in the interstices between the pillow elements, the facing elements and connecting shafts being movable to momentarily separate the pillow elements so as to enable the facing elements to shift from one interstice to another interstice selectively. The frame includes parking slots where unused facing elements may be stored, or in the alternative, where one or more facing elements may be parked to provide room to move the remaining facing elements.