Patents by Inventor Clive A. Slaughter

Clive A. Slaughter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulators of the proteasome
    Patent number: 5847076
    Abstract: Regulators of the activation of the 20S proteasome for hydrolysis of peptide and protein substrates. Proteasome activating factors PA28 and PA700 are described and a carboxy-terminal fragment of a protein activator PA28 is described that is an effective inhibitor of the activation of the proteasome. The carboxy-terminal fragment binds to the proteasome and prevents the binding of PA28 and PA700 thereby preventing activation of the proteasome. Methods of treatment for muscle wasting are described wherein compositions of the present invention are administered to prevent unwanted protein degradation. Conversely, compositions of the present invention may be used to activate protein breakdown in situations where unwanted proteins accumulate in, for example, aging and Alzheimer's Disease.
    Type: Grant
    Filed: May 20, 1993
    Date of Patent: December 8, 1998
    Assignee: Board of Regents, The University of Texas System
    Inventors: George N. DeMartino, Clive A. Slaughter, Patricia J. Willy, Ma Chu-Ping