Patents by Inventor Clive H. Wasserfall

Clive H. Wasserfall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230384222
    Abstract: Autofluorescence is the inherent emission of light from cells or tissues that occurs when biological samples are exposed to different wavelengths of excitation light. Tissue autofluorescence is usually ascribed to biological components such as flavins, porphyrins, chlorophyll (in plants), collagen, elastin, red blood cells (RBCs), and lipofuscin. Tissue autofluorescence often presents a significant problem in microscopy, pathology, and surgical applications. Autofluorescence interferes and complicates signal detection in a variety of fluorescence microscopy methods. Tissue autofluorescence reduces the signal detection sensitivity, and in some cases may cause failure in the detection of fluorescent dye signals. Accordingly, there is a need for further improved methods to decrease the autofluorescence intensity from microscopy samples both in research and clinical venues.
    Type: Application
    Filed: May 25, 2023
    Publication date: November 30, 2023
    Inventors: Harry S. Nick, Clive H. Wasserfall, Seith W. Currlin, Jerelyn A. Nick, Andrew J. Nick
  • Patent number: 11567088
    Abstract: Type 1 diabetes (T1D) patients make antibodies to self-proteins that are potential biomarkers for early detection and risk prediction. We have identified seventeen antigens as biomarkers for early diagnosis and risk prediction of T1D, including the antigens MLH1, MTIF3, PPIL2, NUP50, TOX4, FIGN, C9orf142, ZNF280D, HES1, QRFPR, CTRC, SNX6, SYTL4, ELA2A, IGRP, PAX6, and HMGN3.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: January 31, 2023
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.
    Inventors: Joshua LaBaer, Ji Qiu, Xiaofang Bian, Desmond A. Schatz, Clive H. Wasserfall, Mark A. Atkinson
  • Publication number: 20200182887
    Abstract: Type 1 diabetes (T1D) patients make antibodies to self-proteins that are potential biomarkers for early detection and risk prediction. We have identified seventeen antigens as biomarkers for early diagnosis and risk prediction of T1D, including the antigens MLH1, MTIF3, PPIL2, NUP50, TOX4, FIGN, C9orf142, ZNF280D, HES1, QRFPR, CTRC, SNX6, SYTL4, ELA2A, IGRP, PAX6, and HMGN3.
    Type: Application
    Filed: February 14, 2020
    Publication date: June 11, 2020
    Applicants: Arizona Board of Regents on behalf of Arizona State University, University of Florida Research Foundation, Incorporated
    Inventors: Joshua LaBaer, Ji Qiu, Xiaofang Bian, Desmond A. Schatz, Clive H. Wasserfall, Mark A. Atkinson
  • Publication number: 20160195546
    Abstract: Type 1 diabetes (T1D) patients make antibodies to self-proteins that are potential biomarkers for early detection and risk prediction. We have identified seventeen antigens as biomarkers for early diagnosis and risk prediction of T1D, including the antigens MLH1, MTIF3, PPIL2, NUP50, TOX4, FIGN, C9orf142, ZNF280D, HES1, QRFPR, CTRC, SNX6, SYTL4, ELA2A, IGRP, PAX6, and HMGN3.
    Type: Application
    Filed: January 7, 2016
    Publication date: July 7, 2016
    Applicants: Arizona Board of Regents on behalf of Arizona State University, University of Florida Research Foundation, Incorporated
    Inventors: Joshua LaBaer, Ji Qiu, Xiaofang Bian, Desmond A. Schatz, Clive H. Wasserfall, Mark A. Atkinson
  • Patent number: 8594949
    Abstract: Biomarkers that are diagnostic of type 1 diabetes, type 2 diabetes and/or diabetic disorder are identified. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of type 1 diabetes, type 2 diabetes and/or diabetic disorder. An analysis includes the parameters of matching for BMI and Tanner stage. Receiver-operator characteristic (ROC) curves were established to assess association of the biomarkers with a disease.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: November 26, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Tamir M. Ellis, Alba Esther Morales, Mark A. Atkinson, Clive H. Wasserfall
  • Publication number: 20120077709
    Abstract: Biomarkers that are diagnostic of type 1 diabetes, type 2 diabetes and/or diabetic disorder are identified. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of type 1 diabetes, type 2 diabetes and/or diabetic disorder. An analysis includes the parameters of matching for BMI and Tanner stage. Receiver-operator characteristic (ROC) curves were established to assess association of the biomarkers with a disease.
    Type: Application
    Filed: September 26, 2011
    Publication date: March 29, 2012
    Inventors: Tamir M. Ellis, Alba Esther Morales, Mark A. Atkinson, Clive H. Wasserfall
  • Publication number: 20100120629
    Abstract: Biomarkers that are diagnostic of type 1 diabetes, type 2 diabetes and/or diabetic disorder are identified. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of type 1 diabetes, type 2 diabetes and/or diabetic disorder. An analysis includes the parameters of matching for BMI and Tanner stage. Receiver-operator characteristic (ROC) curves were established to assess association of the biomarkers with a disease.
    Type: Application
    Filed: January 18, 2010
    Publication date: May 13, 2010
    Inventors: Tamir M. Ellis, Alba Esther Morales, Mark A. Atkinson, Clive H. Wasserfall
  • Patent number: 7648825
    Abstract: Biomarkers that are diagnostic of type 1 diabetes, type 2 diabetes and/or diabetic disorder are identified. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of type 1 diabetes, type 2 diabetes and/or diabetic disorder. An analysis includes the parameters of matching for BMI and Tanner stage. Receiver-operator characteristic (ROC) curves were established to assess association of the biomarkers with a disease.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: January 19, 2010
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Tamir M. Ellis, Alba Esther Morales, Mark A. Atkinson, Clive H. Wasserfall