Patents by Inventor Clive King

Clive King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGHLY PURIFIED BATCHES OF PHARMACEUTICAL GRADE 1-DEOXYGALACTONOJIRIMYCIN COMPOUNDS
    Publication number: 20250236592
    Abstract: Provided are methods of producing Active Pharmaceutical Ingredient (API) grade migalastat hydrochloride, and for purifying intermediate grade migalastat hydrochloride. Further provided are methods of producing [(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl) piperidine-3,4,5-triol hydrochloride (lucerastat hydrochloride) and other 1-deoxygalactonojirimycin compounds, as well as methods of purifying intermediate grade lucerastat hydrochloride and other 1-deoxygalactonojirimycin compounds.
    Type: Application
    Filed: April 11, 2025
    Publication date: July 24, 2025
    Applicant: Amicus Therapeutics, Inc.
    Inventors: Kamlesh Sheth, Sergey Tesler, James Cartwright, Clive King, Wendy Cross
  • Highly purified batches of pharmaceutical grade migalastat and methods of producing the same
    Patent number: 12275703
    Abstract: Provided are methods of producing Active Pharmaceutical Ingredient (API) grade migalastat hydrochloride, and for purifying intermediate grade migalastat hydrochloride. Further provided are methods of producing [(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride (lucerastat hydrochloride) and other 1-deoxygalactonojirimycin compounds, as well as methods of purifying intermediate grade lucerastat hydrochloride and other 1-deoxygalactonojirimycin compounds.
    Type: Grant
    Filed: June 26, 2023
    Date of Patent: April 15, 2025
    Assignee: Amicus Therapeutics, Inc.
    Inventors: Kamlesh Sheth, Sergey Tesler, James Cartwright, Clive King, Wendy Cross
  • Highly Purified Batches Of Pharmaceutical Grade Migalastat And Methods Of Producing The Same
    Publication number: 20230348388
    Abstract: Provided are methods of producing Active Pharmaceutical Ingredient (API) grade migalastat hydrochloride, and for purifying intermediate grade migalastat hydrochloride. Further provided are methods of producing [(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride (lucerastat hydrochloride) and other 1-deoxygalactonojirimycin compounds, as well as methods of purifying intermediate grade lucerastat hydrochloride and other 1-deoxygalactonojirimycin compounds.
    Type: Application
    Filed: June 26, 2023
    Publication date: November 2, 2023
    Applicant: Amicus Therapeutics, Inc.
    Inventors: Kamlesh Sheth, Sergey Tesler, James Cartwright, Clive King, Wendy Cross
  • Highly purified batches of pharmaceutical grade 1-deoxygalactonojirimycin compounds
    Patent number: 11685718
    Abstract: Provided are methods of producing Active Pharmaceutical Ingredient (API) grade migalastat hydrochloride, and for purifying intermediate grade migalastat hydrochloride. Further provided are methods of producing [(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride (lucerastat hydrochloride) and other 1-deoxygalactonojirimycin compounds, as well as methods of purifying intermediate grade lucerastat hydrochloride and other 1-deoxygalactonojirimycin compounds.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: June 27, 2023
    Assignee: Amicus Therapeutics, inc.
    Inventors: Kamlesh Sheth, Sergey Tesler, James Cartwright, Clive King, Wendy Cross
  • Highly purified batches of pharmaceutical grade migalastat and methods of producing the same
    Patent number: 11623916
    Abstract: Provided are methods of producing a batch of 1,2,3,6-tetrapivaloyl-D-galactofuranoside; 5-azido-5-deoxy-1,2,3,6-tetrapivaloyl-D-galactofuranoside; intermediate grade migalastat hydrochloride; and/or migalastat hydrochloride. Also provided are methods of determining the purity of a batch of 1,2,3,6-tetrapivaloyl-D-galactofuranoside; 5-azido-5-deoxy-1,2,3,6-tetrapivaloyl-D-galactofuranoside; intermediate grade migalastat hydrochloride; and/or migalastat hydrochloride. Also provided are methods of distributing a batch of 1,2,3,6-tetrapivaloyl-D-galactofuranoside; 5-azido-5-deoxy-1,2,3,6-tetrapivaloyl-D-galactofuranoside; intermediate grade migalastat hydrochloride; and/or migalastat hydrochloride. Also provided are methods of assessing suitability of migalastat hydrochloride for medical use.
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: April 11, 2023
    Assignee: Amicus Therapeutics, Inc.
    Inventors: Kamlesh Sheth, Sergey Tesier, James Cartwright, Clive King, Wendy Cross