Patents by Inventor Clive Miles
Clive Miles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100112683Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: December 4, 2007Publication date: May 6, 2010Applicant: Applied Biosystems, LLCInventors: John Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Publication number: 20090155765Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: November 5, 2008Publication date: June 18, 2009Applicant: Applied Biosystems Inc.Inventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Rahusa, Richard Leath, Clive Miles
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Patent number: 7504241Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: GrantFiled: May 12, 2006Date of Patent: March 17, 2009Assignee: Applied Biosystems, LLCInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Publication number: 20080299651Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: December 4, 2007Publication date: December 4, 2008Applicant: Applera CorporationInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Publication number: 20080138887Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: May 12, 2006Publication date: June 12, 2008Applicant: Applera CorporationInventors: John Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Patent number: 7238517Abstract: An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.Type: GrantFiled: October 22, 2003Date of Patent: July 3, 2007Assignee: Applera CorporationInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Publication number: 20060286659Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: May 12, 2006Publication date: December 21, 2006Applicant: Applera CorporationInventors: John Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Publication number: 20060269641Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: May 12, 2006Publication date: November 30, 2006Applicant: Applera CorporationInventors: John Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Publication number: 20050084957Abstract: A sample tube including a cylindrical part and a conical part is described. The cylindrical part can include, a first wall portion having a first wall portion thickness, a second wall portion having a second wall portion thickness, and a shoulder including a planar first surface and a conically beveled second surface disposed between the first wall portion and the second wall portion. The first wall portion can be disposed closer to the planar first surface than the conically beveled second surface. The conical part can be shaped as a frustrum of a cone having a conical part wall thickness. The frustrum can include a wider-end and a narrower-end. The wider-end of the frustrum can be in contact with the second wall portion of the cylindrical part. At least one of the first wall portion thickness and the second wall portion thickness can be greater than the conical part wall thickness.Type: ApplicationFiled: August 30, 2004Publication date: April 21, 2005Applicant: Applera CorporationInventors: John Atwood, Susan Stone, Judith Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Publication number: 20040248146Abstract: An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.Type: ApplicationFiled: October 22, 2003Publication date: December 9, 2004Applicant: Applera CorporationInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams Brookfield, Marcel Margulies, Robert P. Ragusa, Richard Leath, Timothy M. Woudenberg, Clive Miles
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Publication number: 20040086927Abstract: An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.Type: ApplicationFiled: October 22, 2003Publication date: May 6, 2004Applicant: Applera Corporation, a DE corporationInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Publication number: 20020072112Abstract: An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.Type: ApplicationFiled: January 11, 2000Publication date: June 13, 2002Inventors: JOHN GIRDNER ATWOOD, ALBERT CARMELO MOSSA, LISA MAY GOVEN, FENTON WILLIAMS, TIMOTHY M. WOUDENBERG, MARCEL MARGOULIES, ROBERT P. RAGUSA, RICHARD LEATH, CLIVE MILES
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Patent number: 5710381Abstract: A two-piece plastic holder for loosely holding microliter sample tubes of a preselected design, each tube having a cylindrically shaped upper section open at its top end, a closed, tapered lower section extending downwardly therefrom, and a circumferential shoulder extending outwardly from the upper section at a position on the upper section spaced from the open end thereof. The holder includes a one-piece tray member and a one-piece retainer. The one-piece tray member including a flat, horizontal plate section containing holes in a rectangular array, a first vertical tray sidewall section around the plate extending upwardly to a height greater than the height of a tube resting in one of the holes, and a second vertical tray sidewall section around the plate extending downwardly approximately to the bottom of the upper section of a tube resting in one of the holes. The one-piece retainer is releasably engageable inside the tray over any sample tubes resting in the tray.Type: GrantFiled: March 1, 1994Date of Patent: January 20, 1998Assignee: The Perkin-Elmer CorporationInventors: John Girdner Atwood, Albert Carmelo Mossa, Lisa May Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Patent number: 5602756Abstract: An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.Type: GrantFiled: December 8, 1995Date of Patent: February 11, 1997Assignee: The Perkin-Elmer CorporationInventors: John G. Atwood, Albert C. Mossa, Lisa M. Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Patent number: 5475610Abstract: An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.Type: GrantFiled: April 20, 1992Date of Patent: December 12, 1995Assignee: The Perkin-Elmer CorporationInventors: John G. Atwood, Albert C. Mossa, Lisa M. Goven, Fenton Williams, Timothy M. Woudenberg, Marcel Margoulies, Robert P. Ragusa, Richard Leath, Clive Miles
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Patent number: 4551131Abstract: A movable blood aspiration wand, especially for use in autotransfusion, carries with it a tank for anticoagulant replenished from an anticoagulant source fixed at a high source and is connected to a blood reservoir at a low elevation. Differences in wand height relative to the source and to the blood reservoir are compensated for, so that differences in wand height and corresponding blood and anticoagulant head do not substantially vary the anticoagulant proportion added to the aspirated blood.Type: GrantFiled: May 2, 1983Date of Patent: November 5, 1985Assignee: Thoratec Laboratories CorporationInventors: Clive Miles, Gary Schneiderman
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Patent number: 4540406Abstract: Anticoagulant is added to blood being aspirated through a hand-held wand having a venturi throat. The anticoagulant flows into the wand from a generally closed anticoagulant reservoir higher than the wand as replacement air flows into the anticoagulant air reservoir. This air inflow is controlled by a regulator fixed on the wand and in accordance with the amount of aspirated blood flowing in through the venturi throat.Type: GrantFiled: May 2, 1983Date of Patent: September 10, 1985Assignee: Thoratec Laboratories CorporationInventor: Clive Miles
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Patent number: 4476708Abstract: A flow controller primarily for breathing gas analysis has a gas flow circuit leading from a breathing air inlet to a gas analyzer and to a vacuum source. Another gas is bled into the circuit between the breathing air inlet and a point upstream of the vacuum source. Such other gas is precluded from flowing upstream in the circuit toward the gas analyzer by making the intervening flow path or conduit of suitable dimensions to have a Peclet number at least equal to 4 and preferably greater than 4 and about 6.Type: GrantFiled: November 12, 1982Date of Patent: October 16, 1984Assignee: Thoratec Laboratories CorporationInventors: Kenneth J. Baker, Keith E. Buck, Irving C. Chase, Robert B. Fraser, Clive Miles