Abstract: Provided herein are methods for treating or preventing a condition, and/or symptom or clinical manifestation, associated with systemic infection wherein a subject is intravenously administered ascorbic acid or a pharmaceutically acceptable salt, ester or isomer thereof in an amount of between about 700 mg/kg body weight and about 4,000 mg/kg body weight per day, optionally as a first bolus infusion followed by a subsequent continuous infusion. Also provided are methods comprising intravenously administering to the subject ascorbic acid or a pharmaceutically acceptable salt, ester or isomer thereof: (i) as a bolus dose of from about 350 mg/kg body weight to about 500 mg/kg body weight; and (ii) following (i), by continuous infusion over at least several hours at a dose of from about 60 mg/kg body weight/hr to about 500 mg/kg body weight/hr. Typically, the condition is sepsis or septic shock.

Abstract: Novel flavonoid compounds having anti-oxidant activity are described. The compounds and compositions have been shown to exhibit anti-oxidant properties and are particularly useful in the treatment of ischemia and reperfusion injuries. The invention also describes a method to chemically synthesize such flavonoid compounds and test their efficacy. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have uses in the areas of pharmaceuticals, nutraceutical, and veterinary applications.

Abstract: Novel flavonoid compounds having anti-oxidant activity are described. The compounds and compositions have been shown to exhibit anti-oxidant properties and are particularly useful in the treatment of ischemia and reperfusion injuries. The invention also describes a method to chemically synthesize such flavonoid compounds and test their efficacy. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have uses in the areas of pharmaceuticals, nutraceutical, and veterinary applications.