Abstract: A limiter for a dispensing device is provided. The limiter includes a body (20) arranged to mount with at least a portion of a dispensing device (300), and a stop extending from the body. The stop (40) is configured to permit movement a plunger of the dispensing device a predetermined distance in a dispensing direction correlated to a desired volume of medium to be delivered from the dispensing device. The stop is configured to prevent further movement of the plunger in the dispensing direction, thereby limiting the amount of medium delivered from the dispensing device. The dispensing device may be a syringe.

Abstract: A limiter for a dispensing device is provided. The limiter includes a body (20) arranged to mount with at least a portion of a dispensing device (300), and a stop extending from the body. The stop (40) is configured to permit movement a plunger of the dispensing device a predetermined distance in a dispensing direction correlated to a desired volume of medium to be delivered from the dispensing device. The stop is configured to prevent further movement of the plunger in the dispensing direction, thereby limiting the amount of medium delivered from the dispensing device. The dispensing device may be a syringe.

Abstract: Miniature swine whose genomes contain sequences characteristic of pig endogenous retrovirus genes but which are non-infectious to humans are disclosed as sources of organs, tissues and cells for introduction into human recipients afflicted with diseases, or at risk of diseases, whose etiology involves the presence of inadequately functioning organs and for which xenotransplantation of such organs, tissues and cells would have a palliative effect. Methods of producing such animals and for screening animals for the desired properties are also disclosed.

Abstract: Isolated polynucleotides and polypeptides derived from the genome of swine gamma-herpesviruses are disclosed, including recombinant cells and vectors encoding such polypeptides and expressing such polynucleotides. Use of the novel polynucleotides as probes of the swine genome is also described. Assay methods employing antibodies against the isolated polypeptides are also disclosed.

Abstract: Miniature swine whose genomes contain sequences characteristic of pig endogenous retrovirus genes but which are non-infectious to humans are disclosed as sources of organs, tissues and cells for introduction into human recipients afflicted with diseases, or at risk of diseases, whose etiology involves the presence of inadequately functioning organs and for which xenotransplantation of such organs, tissues and cells would have a palliative effect. Methods of producing such animals and for screening animals for the desired properties are also disclosed.

Abstract: Polypeptide sequences for PERV-A receptors found on primate cells, including human, and the polynucleotides encoding those polypeptide receptor sequences are disclosed along with processes for using the PERV-A receptors in both in vitro and in vivo screening assays and models for agents that block viral infection. Also disclosed are processes for detecting the presence of PERV receptors in a tissue, blocking virus binding to receptors and protection of an animal, such as a human patient, from PERV infection. Antibodies that react with PERV receptors, vectors comprising the polynucleotides encoding such receptors and recombinant cells that express these receptors are also described.

Abstract: Isolated polynucleotides and polypeptides derived from the genome of swine gamma-herpesviruses are disclosed, including recombinant cells and vectors encoding such polypeptides and expressing such polynucleotides. Use of the novel polynucleotides as probes of the swine genome is also described. Assay methods employing antibodies against the isolated polypeptides are also disclosed.

Abstract: Isolated polynucleotides and polypeptides derived from the genome of swine gamma-herpesviruses are disclosed, including recombinant cells and vectors encoding such polypeptides and expressing such polynucleotides. Use of the novel polynucleotides as probes of the swine genome is also described. Assay methods employing antibodies against the isolated polypeptides are also disclosed.

Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptides of the present invention are PERV-D env polypeptides. The invention also relates to detecting the presence of a porcine retrovirus in tissue comprising such polypeptides or polynucleotides that encode the polypeptides.

Abstract: Miniature swine whose genomes contain sequences characteristic of pig endogenous retrovirus genes but which are non-infectious to humans are disclosed as sources of organs, tissues and cells for introduction into human recipients afflicted with diseases, or at risk of diseases, whose etiology involves the presence of inadequately functioning organs and for which xenotransplantation of such organs, tissues and cells would have a palliative effect. Methods of producing such animals and for screening animals for the desired properties are also disclosed.

Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptides of the present invention are PERV-D env polypeptides. The invention also relates to detecting the presence of a porcine retrovirus in tissue comprising such polypeptides or polynucleotides that encode the polypeptides.