Patents by Inventor Clive S. Woodhouse

Clive S. Woodhouse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced production of antibodies utilizing insolubilized immune complexes
    Patent number: 5084396
    Abstract: A method for enhancing production of antibodies through immunization with insolubilized immune complexes is disclosed. Purified antigen or heterogeneous antigen mixtures may be combined with polyclonal or monoclonal antibody and the resultant complex bound to an insolubilized matrix to form insolubilized immune complexes. Methods for improving the immunogenicity of a soluble antigen and for producing monoclonal anti-iodiotypic antibodies are also disclosed. Monoclonal antibodies that are specific for a distinct, as yet unrecognized epitope may be produced by another disclosed method . Insolubilized immune complexes, comprising antigen and antibody that is ether directly linked to Sepharose.RTM. or absorbed onto insolubilized protein A, and immunosorbents, comprising antibody absorbed onto insolubilized protein A, are also disclosed.
    Type: Grant
    Filed: September 7, 1990
    Date of Patent: January 28, 1992
    Assignee: Neorx Corporation
    Inventors: A. Charles Morgan, Jr., Clive S. Woodhouse, Robert F. McIntyre
  • Enhanced production of antibodies utilizing insolubilized immune complexes
    Patent number: 4879225
    Abstract: A method for enhancing production of antibodies through immunization with insolubilized immune complexes is disclosed. Purified antigen or heterogeneous antigen mixtures may be combined with polyclonal or monoclonal antibody and the resultant complex bound to insolubilized protein A to form insolubilized immune complexes. Methods for improving the immunogenicity of a soluble antigen and for producing monoclonal anti-idiotypic antibodies are also disclosed. Monoclonal antibodies that are specific for a distinct, as yet unrecognized epitope may be produced by another disclosed method. Insolubilized immune complexes, comprising antigen and antibody that is either directly linked to Sepharose.RTM. or absorbed onto insolubolized protein A, and immunosorbents, comprising antibody absorbed onto insolubilized protein A, are also disclosed.
    Type: Grant
    Filed: March 11, 1987
    Date of Patent: November 7, 1989
    Assignee: NeoRx Corporation
    Inventors: Alton C. Morgan, Jr., Clive S. Woodhouse, Robert F. McIntyre
  • Method for improving the elicitation of IgG class monoclonal antibodies to tumor-associated antigens and glycoproteins
    Patent number: 4822734
    Abstract: Methods are disclosed for improving the efficiency of elicitation of monoclonal antibodies to glycoprotein antigens and tumor-associated antigens, and for inducing the production of IgG class monoclonal antibodies, in particular the IgG.sub.3 subclass. The methods involve the use of a lectin/extract immunogen to stimulate the production of the desired monoclonal antibodies.
    Type: Grant
    Filed: September 6, 1985
    Date of Patent: April 18, 1989
    Assignee: NeoRx Corporation
    Inventors: Alton C. Morgan, Jr., Robert McIntyre, Clive S. Woodhouse, Paul G. Abrams