Abstract: A prosthesis comprising: an inner layer formed from a polyaryletherketone; a first outer layer adjacent to said inner layer formed from a porous polyaryletherketone, at least some of said pores having located therein material to promote osteointegration; and a second outer layer adjacent to said first outer layer formed from a porous polyaryletherketone, a portion of said pores being free of material to promote osteointegration. The invention also relates to a method of manufacture of the prosthesis. In an alternative arrangement, the prosthesis comprises: an inner layer formed from a polyaryletherketone; a first outer layer adjacent to said inner layer formed from a porous polyaryletherketone, at least some of said pores having located therein material to promote osteointegration having a crystallinity of from about 60% to about 90%; and a second outer layer adjacent to said first outer layer formed from a porous polyaryletherketone.

Abstract: An acetabular cup prosthesis comprising an acetabular cup having a rim and comprising a metal band applied around the outer circumference of the acetabular cup prosthesis and adjacent to said rim.

Abstract: A trial acetabular cup having a signal generating device located thereon.

Abstract: Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation apparatus can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation apparatus can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation apparatus can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device.

Abstract: A trial acetabular cup having a signal generating device located thereon.

Abstract: A prosthesis comprising: an inner layer formed from a polyaryletherketone; a first outer layer adjacent to said inner layer formed from a porous polyaryletherketone, at least some of said pores having located therein material to promote osteointegration; and a second outer layer adjacent to said first outer layer formed from a porous polyaryletherketone, a portion of said pores being free of material to promote osteointegration. The invention also relates to a method of manufacture of the prosthesis.

Abstract: Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation apparatus can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation apparatus can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation apparatus can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device.

Abstract: Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation apparatus can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation apparatus can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation apparatus can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device.

Abstract: A prosthesis comprising: an inner layer (4) formed from a polyaryletherketone; a first outer layer (2a) adjacent to said inner layer formed from a porous polyaryletherketone, at least some of said pores having located therein material to promote osteointegration; and a second outer layer (2b) adjacent to said first outer layer formed from a porous polyaryletherketone, a portion of said pores being free of material to promote osteointegration. The invention also relates to a method of manufacture of the prosthesis.

Abstract: A cup prosthesis includes a cup, a band disposed about the outer circumference and adjacent to the rim of the cup, an impaction cap disposed at least partially within the space defined by the inner surface and the rim of the cup, and at least one flange extending from the band connected on one end to the impaction cap.

Abstract: A prosthesis comprising: an inner layer (4) formed from a polyaryletherketone; a first outer layer (2a) adjacent to said inner layer formed from a porous polyaryletherketone, at least some of said pores having located therein material to promote osteointegration; and a second outer layer (2b) adjacent to said first outer layer formed from a porous polyaryletherketone, a portion of said pores being free of material to promote osteointegration. The invention also relates to a method of manufacture of the prosthesis.

Abstract: A prosthesis comprising a plastics body and a plurality of barbed stakes extending from a bone-facing surface of said body; said stakes being sized and located to provide fixation on impaction

Abstract: Multi-valve autoregulatory microfluidic devices and methods are described. The described devices and methods offer improved performance and new means of tuning autoregulatory effects in microfluidic devices.

Abstract: A preassembled acetabular cup prosthesis comprising an outer shell and a ceramic liner located within the shell, said preassembled unit having been assembled ex-vivo under a controlled force selected to optimize the pre-stressing of the components of the prosthesis.

Abstract: An acetabular cup prosthesis comprising an acetabular cup having a rim and comprising a metal band applied around the outer circumference of the acetabular cup prosthesis and adjacent to said rim.

Abstract: In a saw for the removal of a prosthesis which is integrated with a bone, a blade is connected to a handle wherein the distal end of the blade includes a shaped nib. The shaped nib has teeth, with at least some of the teeth being angled to cut as the saw is moved in a backward direction. The nib additionally includes means for allowing the nib to be reversibly deformed such that in use its maximum width can be temporarily reduced.

Abstract: Described herein is a method for detection of a target in a sample and related devices and systems.

Abstract: An acetabular cup prosthesis having a rim and comprising a metal band applied around the outer circumference of the acetabular cup prosthesis and adjacent to said rim, said cup prosthesis additionally comprising one or more flanges extending from the metal band and being configured such that in use the or each flange connects the prosthesis to an impaction cup.

Abstract: Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation apparatus can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation apparatus can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation apparatus can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device.

Abstract: Described herein is a method for detection of a target in a sample and related devices and systems.