Patents by Inventor Clotilde K. S. Carlow

Clotilde K. S. Carlow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA and protein from Dirofilaria immitis
    Patent number: 6790630
    Abstract: In accordance with the present invention, a 31-33 kDa glycoprotein of D. immitis (DiT33) is provided which represents another member of the family of putative pepsin inhibitors. Other known members include Ov33 (a.k.a. Ov33.3, Oc3.6, OvD 5B), Bm33 and Av33. These filarial molecules possess significant homology to the known pepsin inhibitor (Aspi3) of A. suum. Using DiT33 or Ov33, in the form of a recombinant fusion or non-fusion protein, antibody responses to DiT33 may be monitored and used in immunodiagnosis of heartworm infection in mammals. Antibodies reactive with the DiT33 or Ov33 may also be used to detect DiT33 antigen as a means of immunodiagnosis of heartworm infection in mammals.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: September 14, 2004
    Assignee: New England Biolabs, Inc.
    Inventors: Clotilde K. S. Carlow, Francine B. Perler, XiaQiang Hong, Jhon Santiago Mejia
  • Tyrosine-containing cyclophilin and related methods
    Patent number: 6649395
    Abstract: The present invention relates to the use of these cyclophilins, hereinafter referred to as ‘tyrosine-containing’ cyclophilins, in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such compounds may be further screened for their ability to inhibit parasites which are not susceptible to the anti-parasitic effects of CsA.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: November 18, 2003
    Assignee: New England Biolabs, Inc.
    Inventors: Clotilde K. S. Carlow, Xiqiang Hong, Dong Ma
  • Tyrosine-containing cyclophilin and related methods
    Patent number: 6150501
    Abstract: The present invention relates to the use of these cyclophilins, hereinafter referred to as `tyrosine-containing` cyclophilins, in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such compounds may be further screened for their ability to inhibit parasites which are not susceptible to the anti-parasitic effects of CsA.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: November 21, 2000
    Assignee: New England Biolabs, Inc.
    Inventors: Clotilde K. S. Carlow, Xiqiang Hong, Dong Ma
  • Isolation and production of a cyclophilin-like protein endogenous to brugia malayi
    Patent number: 6127148
    Abstract: The present invention relates to the use of nematode "cyclophilin-like proteins (CLP)", in a method for identifying compounds capable of binding to and/or inhibiting the peptidyl-prolylcistransisomerase activity of these proteins. Such compounds may be further screened for their ability to inhibit nematode parasites which are not susceptible to the anti-parasitic effects of CsA.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: October 3, 2000
    Assignee: New England Biolabs, Inc.
    Inventors: Clotilde K. S. Carlow, Antony Page
  • Method for immunodiagnosis of heartworm in mammals
    Patent number: 6103484
    Abstract: In accordance with the present invention, a 31-33 kDa glycoprotein of D. immitis (DiT33) is provided which represents another member of the family of putative pepsin inhibitors. Other known members include Ov33 (a.k.a. Ov33.3, Oc3.6, OvD 5B), Bm33 and Av33. These filarial molecules possess significant homology to the known pepsin inhibitor (Aspi3) of A. suum. Using DiT33 or Ov33, in the form of a recombinant fusion or non-fusion protein, antibody responses to DiT33 may be monitored and used in immunodiagnosis of heartworm infection in mammals. Antibodies reactive with the DiT33 or Ov33 may also be used to detect DiT33 antigen as a means of immunodiagnosis of heartworm infection in mammals.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: August 15, 2000
    Assignee: New England Biolabs, Inc.
    Inventors: Clotilde K. S. Carlow, Francine B. Perler, XiaQiang Hong, Jhon Santiago Mejia
  • Method for identifying anti-nematode compounds
    Patent number: 5821107
    Abstract: The present invention relates to the use of these cyclophilins, hereinafter referred to as "cyclophilin-like proteins (CLP)" in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such compounds may be further screened for their ability to inhibit parasites which are not susceptible to the anti-parasitic effects of CsA.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: October 13, 1998
    Assignee: New England Biolabs, Inc.
    Inventors: Clotilde K. S. Carlow, Antony Page
  • Method for identifying anti-parasitic compounds
    Patent number: 5482850
    Abstract: The present invention relates to the use of these cyclophilins, hereinafter referred to as "cyclophilin-like proteins (CLP)", in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such compounds may be further screened for their ability to inhibit parasites which are not susceptible to the anti-parasitic effects of CsA.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: January 9, 1996
    Assignee: New England Biolabs, Inc.
    Inventors: Clotilde K. S. Carlow, Antony Page