Patents by Inventor Cloud P. Paweletz

Cloud P. Paweletz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Denaturation-enhanced DNA mutation testing for limited biological specimens
    Patent number: 11884970
    Abstract: Disclosed herein are methods to improve the efficiency of absolute quantification of nucleic acid targets such as digital PCR and digital isothermal amplification, and/or reduce the amount of nucleic acid sample required to determine the absolute quantity of target sequences in the sample.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: January 30, 2024
    Assignee: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Gerassimos Makrigiorgos, Cloud P. Paweletz
  • Methods for evaluating tumor cell spheroids using 3D microfluidic cell culture device
    Patent number: 11572590
    Abstract: Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: February 7, 2023
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Russell W. Jenkins, David Barbie, Cloud P. Paweletz, Elena Ivanova, Amir Aref
  • NON-INVASIVE BLOOD BASED MONITORING OF GENOMIC ALTERATIONS IN CANCER
    Publication number: 20220090203
    Abstract: The invention provides methods to monitor cell free nucleic acids.
    Type: Application
    Filed: November 12, 2020
    Publication date: March 24, 2022
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Pasi A. Janne, Cloud P. Paweletz, Geoffrey Oxnard, Yanan Kuang
  • METHODS FOR EVALUATING TUMOR CELL SPHEROIDS USING 3D MICROFLUIDIC CELL CULTURE DEVICE
    Publication number: 20210363595
    Abstract: Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.
    Type: Application
    Filed: July 19, 2021
    Publication date: November 25, 2021
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: David Barbie, Russell W. Jenkins, Cloud P. Paweletz, Elena Ivanova, Amir Aref
  • Methods for evaluating tumor cell spheroids using 3D microfluidic cell culture device
    Patent number: 11098369
    Abstract: Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: August 24, 2021
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: David Barbie, Russell W. Jenkins, Cloud P. Paweletz, Elena Ivanova, Amir Aref
  • DENATURATION-ENHANCED DNA MUTATION TESTING FOR LIMITED BIOLOGICAL SPECIMENS
    Publication number: 20210214778
    Abstract: Disclosed herein are methods to improve the efficiency of absolute quantification of nucleic acid targets such as digital PCR and digital isothermal amplification, and/or reduce the amount of nucleic acid sample required to determine the absolute quantity of target sequences in the sample.
    Type: Application
    Filed: May 24, 2019
    Publication date: July 15, 2021
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Gerassimos Makrigiorgos, Cloud P. Paweletz
  • NON-INVASIVE BLOOD BASED MONITORING OF GENOMIC ALTERATIONS IN CANCER
    Publication number: 20210207223
    Abstract: The invention provides methods to monitor cell free nucleic acids.
    Type: Application
    Filed: November 12, 2020
    Publication date: July 8, 2021
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Pasi A. Janne, Cloud P. Paweletz, Geoffrey Oxnard, Yanan Kuang
  • METHODS FOR EVALUATING TUMOR CELL SPHEROIDS USING 3D MICROFLUIDIC CELL CULTURE DEVICE
    Publication number: 20210087635
    Abstract: Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.
    Type: Application
    Filed: March 30, 2018
    Publication date: March 25, 2021
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Russell W. Jenkins, David Barbie, Cloud P. Paweletz, Elena Ivanova, Amir Aref
  • Non-invasive blood based monitoring of genomic alterations in cancer
    Patent number: 10865451
    Abstract: The invention provides methods to monitor cell free nucleic acids.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: December 15, 2020
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Pasi A. Janne, Cloud P. Paweletz, Geoffrey Oxnard, Yanan Kuang
  • Methods for evaluating tumor cell spheroids using 3d microfluidic cell culture device
    Publication number: 20190112666
    Abstract: Provided herein are methods for evaluating tumor cell spheroids in a three-dimensional microfluidic device by determining changes in the relative levels of live cells and dead cells in aliquots cultured under different conditions. Methods described herein allow ex vivo recapitulation of the tumor microenvironment such that the in vivo effectiveness of a test compound in treating tumor tissue may be predicted.
    Type: Application
    Filed: August 17, 2018
    Publication date: April 18, 2019
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: David Barbie, Russell W. Jenkins, Cloud P. Paweletz, Elena Ivanova, Amir Aref
  • NON-INVASIVE BLOOD BASED MONITORING OF GENOMIC ALTERATIONS IN CANCER
    Publication number: 20160138112
    Abstract: The invention provides methods to monitor cell free nucleic acids.
    Type: Application
    Filed: June 11, 2014
    Publication date: May 19, 2016
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Pasi A. Janne, Cloud P. Paweletz, Geoffrey Oxnard, Yanan Kuang
  • RECEPTOR FOR AMYLOID BETA AND USES THEREOF
    Publication number: 20100028333
    Abstract: Compositions and methods for identifying modulators of sortilin are described. The methods are particularly useful for identifying analytes that antagonize sortilin s effect on processing of amyloid precursor protein to A? peptide and thus useful for identifying analytes that can be used for treating Alzheimer disease.
    Type: Application
    Filed: December 11, 2007
    Publication date: February 4, 2010
    Inventors: Krista L. Getty, William J. Ray, Cloud P. Paweletz