Patents by Inventor Clyde G. McNamee

Clyde G. McNamee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
    Patent number: 5686298
    Abstract: An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of compounds useful as intermediates in the preparation of taxanes.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: November 11, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Amit Banerjee, Clyde G. McNamee, John K. Thottathil, Laszlo J. Szarka
  • Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
    Patent number: 5420337
    Abstract: An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of compounds useful as intermediates in the preparation of taxanes.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: May 30, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Amit Banerjee, Clyde G. McNamee, John K. Thottathil, Laszlo J. Szarka
  • Process for selecting an enantiomer of a hydroxy lactone using pseudomonas lipase
    Patent number: 5413935
    Abstract: An enantiomerically pure compound of the formula ##STR1## is prepared when the associated racemic mixture is reacted with an acrylating agent R.sup.3 --C(O)--O--R in the presence of a microorganism or enzyme derived therefrom capable of catalyzing transesterification of an alcohol. X.sup.1 and X.sup.2 are each independently halogen, R is alkyl, R.sup.1 and R.sup.2 are each independently alkyl, cycloalkyl, aralkyl or aryl and R.sup.3 is alkyl, cycloalkyl, aryl or aralkyl.
    Type: Grant
    Filed: March 24, 1993
    Date of Patent: May 9, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Clyde G. McNamee, Laszlo J. Szarka
  • Stereoselective reduction of ketones
    Patent number: 5391495
    Abstract: The present invention concerns a process for the stereoselective enzymatic reduction of keto group-containing compounds such as N-(4-(2-chloroacetyl)phenyl)methanesulfonamido to form the corresponding hydroxyl-group containing compound. The process is selective for the D(+) enantiomer and is catalyzed by enzymes such as oxido-reductase or dehydrogense, or by microorganisms such as Hansenula, Rhodococcus, or Norcardia species.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: February 21, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ramesh N. Patel, Amit Banerjee, Clyde G. McNamee, Laszlo J. Szarka
  • Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
    Patent number: 5324662
    Abstract: Microorganisms or reductases derived therefrom reduce a diketo ester ##STR1## to form the associated 3-hydroxy, 5-hydroxy, or 3,5-dihydroxy esters.
    Type: Grant
    Filed: May 15, 1992
    Date of Patent: June 28, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Clyde G. McNamee, Amit Banerjee, Laszlo J. Szarka
  • Alkaline protease produced by a bacillus
    Patent number: 4764470
    Abstract: A novel enzyme exhibiting proteolytic activity in alkaline media and stability under alkaline conditions is produced by a novel Bacillus strain designated GX6644 or by its mutants or variants. The enzyme is well-suited for inclusion in washing compositions. A culture of GX6644 has been deposited with the American Type Culture Collection, Rockville, Maryland as ATCC No. 53441.
    Type: Grant
    Filed: February 5, 1986
    Date of Patent: August 16, 1988
    Assignee: Genex Corporation
    Inventors: Donald R. Durham, Edmund J. Stellwag, Clyde G. McNamee
  • Enzymatic reduction method for the preparation of halohydrins
    Patent number: H1893
    Abstract: An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of halohydrins from haloketones. The halohydrin products are particularly useful in the preparation of epoxides, which may be employed as intermediates in the preparation of protease inhibitors such as retroviral protease inhibitors.
    Type: Grant
    Filed: July 23, 1996
    Date of Patent: October 3, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ramesh N. Patel, Laszlo J. Szarka, Amit Banerjee, Clyde G. McNamee