Abstract: The present invention is directed to overcoming immunologically mediated nutritional disturbances in pre-ruminant associated with plant protein antigens and to a vaccine therefor. In accordance with the present invention bovine can be fed dietary plant protein, such as soy protein, after being vaccinated in accordance with the vaccine disclosed herein. The regimen comprises administering orally or parenterally to the pre-ruminant bovine an effective amount of the plant protein which is later to be fed to the bovine. After a selected suitable time interval, the bovine then is parenterally administered a second effective amount of said plant protein, thereby permitting the bovine to be fed the dietary plant protein of the vaccine.

Abstract: An improved vaccine and method for immunizing cattle to Shipping Fever Complex type Bovine Respiratory Disease (BRD) which employs an intradermally administered vaccine containing a live culture of Pasteurella sp., particularly, Pasteurella hemolytica. Innoculation is carried out before the animals are subjected to stress factors, including weaning and transportation to feedlots. Also described is a method for preparing the vaccine by incubation of P. hemolytica within an infusion broth.