Patents by Inventor Clyde M. OFNER III

Clyde M. OFNER III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High molecular weight biodegradable gelatin-doxorubicin conjugate
    Patent number: 10265413
    Abstract: Disclosed herein are high molecular weight compounds comprising gelatin and doxorubicin, where the gelatin is covalently linked to doxorubicin through a cleavable linker. The cleavable linker can be cleaved under appropriate physiological conditions, and thus lead to the freeing of doxorubicin. The free doxorubicin can then exert its cytotoxic effects on cancer cells. Disclosed herein are methods of making the high molecular weight gelatin-doxorubicin conjugates and methods of use of the same.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: April 23, 2019
    Assignee: UNIVERSITY OF THE SCIENCES IN PHILADELPHIA
    Inventors: Clyde M. Ofner, III, Chris Cammarata, Brian Rhodes, Darren Wu
  • HIGH MOLECULAR WEIGHT BIODEGRADABLE GELATIN-DOXORUBICIN CONJUGATE
    Publication number: 20170354741
    Abstract: Disclosed herein are high molecular weight compounds comprising gelatin and doxorubicin, where the gelatin is covalently linked to doxorubicin through a cleavable linker. The cleavable linker can be cleaved under appropriate physiological conditions, and thus lead to the freeing of doxorubicin. The free doxorubicin can then exert its cytotoxic effects on cancer cells. Disclosed herein are methods of making the high molecular weight gelatin-doxorubicin conjugates and methods of use of the same.
    Type: Application
    Filed: October 30, 2015
    Publication date: December 14, 2017
    Applicant: UNIVERSITY OF THE SCIENCES IN PHILADELPHIA
    Inventors: Clyde M. OFNER III, Chris CAMMARATA, Brian RHODES, Darren WU