Patents by Inventor Clyde W. Wellen

Clyde W. Wellen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080248095
    Abstract: The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.
    Type: Application
    Filed: January 25, 2008
    Publication date: October 9, 2008
    Inventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nedezhda Koshkina, Brian Gilbert, Clyde W. Wellen
  • Patent number: 7341739
    Abstract: The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: March 11, 2008
    Assignee: Research Development Foundation
    Inventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nadezhda Koshkina, Brian Gilbert, Clyde W. Wellen
  • Publication number: 20040208935
    Abstract: The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.
    Type: Application
    Filed: May 11, 2004
    Publication date: October 21, 2004
    Applicant: Research Development Foundation
    Inventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nadezhda Koshkina, Brian Gilbert, Clyde W. Wellen
  • Patent number: 6750329
    Abstract: The present invention provides a novel conjugate comprising an antibody directed toward a cell surface associated antigen, wherein said antigen is selected from the group consisting of 15A8 antigen and ZME-018 antigen; and a biological response modifier moiety, wherein said moiety is selected from the group consisting of TNF-alpha, TNF-beta and Interleukin-1. In addition, the present invention also provides a method of treating proliferative cell diseases comprising administration of a cytocidally effective dose of the composition of Claim 1 individual in need of said treatment.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: June 15, 2004
    Assignee: Research Development Foundation
    Inventors: Michael G. Rosenblum, Clyde W. Wellen
  • Publication number: 20030236301
    Abstract: The present invention provides a method for treating a cell proliferative disease by delivering a composition comprising a vitamin E based anti-cancer compound contained within a delivery vesicle of an individual in need of such treatment where the compound has a structural formula 1
    Type: Application
    Filed: December 19, 2002
    Publication date: December 25, 2003
    Inventors: Bob Sanders, Kimberly Kline, Karla A. Lawson, J. Vernon Knight, Marla S. Menchaca, Clyde W. Wellen
  • Patent number: 6638354
    Abstract: Disclosed are amorphous precipitated silicas, silica gels, and amorphous carbons derived from biomass and methods of producing them with and without adhered or deposited amorphous carbons produced by acidifying a caustic silicate solution produced by caustic digestion of biomass ash containing silica with and without activated carbon, the ash being obtained from thermal pyrolysis of the biomass, the acidifying effective to produce a slurry of the precipitated silica and silica gels with and without adhered or deposited amorphous carbon, and separated from the slurry the precipitated silicas and silica gels with and without the adhered or deposited amorphous carbons. The properties of the precipitated silica with adhered or deposited carbon being within the range as utilized in rubber compositions thereby avoiding the blending of silica and carbon components for such use.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: October 28, 2003
    Assignees: Agritec, Inc., Occidental Chemical Corporation
    Inventors: Douglas K. Stephens, Clyde W. Wellen, Jeffrey B. Smith, Kenneth F. Kubiak
  • Publication number: 20030097966
    Abstract: Disclosed are amorphous precipitated silicas, silica gels, and amorphous carbons derived from biomass and methods of producing them with and without adhered or deposited amorphous carbons produced by acidifying a caustic silicate solution produced by caustic digestion of biomass ash containing silica with and without activated carbon, the ash being obtained from thermal pyrolysis of the biomass, the acidifying effective to produce a slurry of the precipitated silica and silica gels with and without adhered or deposited amorphous carbon, and separated from the slurry the precipitated silicas and silica gels with and without the adhered or deposited amorphous carbons. The properties of the precipitated silica with adhered or deposited carbon being within the range as utilized in rubber compositions thereby avoiding the blending of silica and carbon components for such use.
    Type: Application
    Filed: January 30, 2002
    Publication date: May 29, 2003
    Applicant: Agritec, Inc.
    Inventors: Douglas K. Stephens, Clyde W. Wellen, Jeffrey B. Smith, Kenneth F. Kubiak
  • Publication number: 20020102296
    Abstract: The small particle liposome or lipid complex aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes or other lipid complexes. The liposomes and complexes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10,11 -methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.
    Type: Application
    Filed: October 1, 2001
    Publication date: August 1, 2002
    Applicant: Research Development Foundation
    Inventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nadezhda Koshkina, Brian Gilbert, Clyde W. Wellen
  • Patent number: 6375735
    Abstract: Disclosed are amorphous precipitated silicas, silica gels, and amorphous carbons derived from biomass and methods of producing them with and without adhered or deposited amorphous carbons produced by acidifying a caustic silicate solution produced by caustic digestion of biomass ash containing silica with and without activated carbon, the ash being obtained from thermal pyrolysis of the biomass, the acidifying effective to produce a slurry of the precipitated silica and silica gels with and without adhered or deposited amorphous carbon, and separated from the slurry the precipitated silicas and silica gels with and without the adhered or deposited amorphous carbons. The properties of the precipitated silica with adhered or deposited carbon being within the range as utilized in rubber compositions thereby avoiding the blending of silica and carbon components for such use.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: April 23, 2002
    Assignees: Agritec, Inc., Occidental Chemical Corporation
    Inventors: Douglas K. Stephens, Clyde W. Wellen, Jeffrey B. Smith, Kenneth F. Kubiak
  • Patent number: 5858911
    Abstract: Disclosed is a rigid fine-celled foam composition and a method of producing it. The foam composition is nontoxic, environmentally friendly, has improved absorption/adsorption and retention of liquids, is not as hard as prior art foams, does not include polymerization by-products detrimental to flower and plant life, and is a foamed mixture of a caustic silicate solution derived from the caustic digestion of rice hull ash having diffused activated carbon particles from thermal pyrolysis of rice hulls rather than from commercial sodium silicate solutions. Valuable by-products of commodity grade are obtained including activated carbon and sodium fluoride.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: January 12, 1999
    Assignee: Agritec, Inc.
    Inventors: Clyde W. Wellen, Douglas K. Stephens, Greg R. Wellen
  • Patent number: 5714000
    Abstract: Disclosed is a rigid fine-celled foam composition and a method of producing it. The foam composition is nontoxic, environmentally friendly, has improved absorption/adsorption and retention of liquids, is not as hard as prior art foams, does not include polymerization by-products detrimental to flower and plant life, and is a foamed mixture of a caustic silicate solution derived from the caustic digestion of rice hull ash having diffused activated carbon particles from thermal pyrolysis of rice hulls rather than from commercial sodium silicate solutions. Valuable by-products of commodity grade are obtained including activated carbon and sodium fluoride.
    Type: Grant
    Filed: July 10, 1996
    Date of Patent: February 3, 1998
    Assignee: Agritec, Inc.
    Inventors: Clyde W. Wellen, Douglas K. Stephens, Greg R. Wellen