Patents by Inventor Clyde W. Wellen
Clyde W. Wellen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080248095Abstract: The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.Type: ApplicationFiled: January 25, 2008Publication date: October 9, 2008Inventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nedezhda Koshkina, Brian Gilbert, Clyde W. Wellen
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Patent number: 7341739Abstract: The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.Type: GrantFiled: May 11, 2004Date of Patent: March 11, 2008Assignee: Research Development FoundationInventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nadezhda Koshkina, Brian Gilbert, Clyde W. Wellen
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Publication number: 20040208935Abstract: The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.Type: ApplicationFiled: May 11, 2004Publication date: October 21, 2004Applicant: Research Development FoundationInventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nadezhda Koshkina, Brian Gilbert, Clyde W. Wellen
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Patent number: 6750329Abstract: The present invention provides a novel conjugate comprising an antibody directed toward a cell surface associated antigen, wherein said antigen is selected from the group consisting of 15A8 antigen and ZME-018 antigen; and a biological response modifier moiety, wherein said moiety is selected from the group consisting of TNF-alpha, TNF-beta and Interleukin-1. In addition, the present invention also provides a method of treating proliferative cell diseases comprising administration of a cytocidally effective dose of the composition of Claim 1 individual in need of said treatment.Type: GrantFiled: May 31, 1994Date of Patent: June 15, 2004Assignee: Research Development FoundationInventors: Michael G. Rosenblum, Clyde W. Wellen
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Publication number: 20030236301Abstract: The present invention provides a method for treating a cell proliferative disease by delivering a composition comprising a vitamin E based anti-cancer compound contained within a delivery vesicle of an individual in need of such treatment where the compound has a structural formula 1Type: ApplicationFiled: December 19, 2002Publication date: December 25, 2003Inventors: Bob Sanders, Kimberly Kline, Karla A. Lawson, J. Vernon Knight, Marla S. Menchaca, Clyde W. Wellen
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Patent number: 6638354Abstract: Disclosed are amorphous precipitated silicas, silica gels, and amorphous carbons derived from biomass and methods of producing them with and without adhered or deposited amorphous carbons produced by acidifying a caustic silicate solution produced by caustic digestion of biomass ash containing silica with and without activated carbon, the ash being obtained from thermal pyrolysis of the biomass, the acidifying effective to produce a slurry of the precipitated silica and silica gels with and without adhered or deposited amorphous carbon, and separated from the slurry the precipitated silicas and silica gels with and without the adhered or deposited amorphous carbons. The properties of the precipitated silica with adhered or deposited carbon being within the range as utilized in rubber compositions thereby avoiding the blending of silica and carbon components for such use.Type: GrantFiled: January 30, 2002Date of Patent: October 28, 2003Assignees: Agritec, Inc., Occidental Chemical CorporationInventors: Douglas K. Stephens, Clyde W. Wellen, Jeffrey B. Smith, Kenneth F. Kubiak
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Publication number: 20030097966Abstract: Disclosed are amorphous precipitated silicas, silica gels, and amorphous carbons derived from biomass and methods of producing them with and without adhered or deposited amorphous carbons produced by acidifying a caustic silicate solution produced by caustic digestion of biomass ash containing silica with and without activated carbon, the ash being obtained from thermal pyrolysis of the biomass, the acidifying effective to produce a slurry of the precipitated silica and silica gels with and without adhered or deposited amorphous carbon, and separated from the slurry the precipitated silicas and silica gels with and without the adhered or deposited amorphous carbons. The properties of the precipitated silica with adhered or deposited carbon being within the range as utilized in rubber compositions thereby avoiding the blending of silica and carbon components for such use.Type: ApplicationFiled: January 30, 2002Publication date: May 29, 2003Applicant: Agritec, Inc.Inventors: Douglas K. Stephens, Clyde W. Wellen, Jeffrey B. Smith, Kenneth F. Kubiak
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Publication number: 20020102296Abstract: The small particle liposome or lipid complex aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes or other lipid complexes. The liposomes and complexes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10,11 -methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.Type: ApplicationFiled: October 1, 2001Publication date: August 1, 2002Applicant: Research Development FoundationInventors: Beppino C. Giovanella, J. Vernon Knight, J. Clifford Waldrep, Nadezhda Koshkina, Brian Gilbert, Clyde W. Wellen
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Patent number: 6375735Abstract: Disclosed are amorphous precipitated silicas, silica gels, and amorphous carbons derived from biomass and methods of producing them with and without adhered or deposited amorphous carbons produced by acidifying a caustic silicate solution produced by caustic digestion of biomass ash containing silica with and without activated carbon, the ash being obtained from thermal pyrolysis of the biomass, the acidifying effective to produce a slurry of the precipitated silica and silica gels with and without adhered or deposited amorphous carbon, and separated from the slurry the precipitated silicas and silica gels with and without the adhered or deposited amorphous carbons. The properties of the precipitated silica with adhered or deposited carbon being within the range as utilized in rubber compositions thereby avoiding the blending of silica and carbon components for such use.Type: GrantFiled: March 31, 2000Date of Patent: April 23, 2002Assignees: Agritec, Inc., Occidental Chemical CorporationInventors: Douglas K. Stephens, Clyde W. Wellen, Jeffrey B. Smith, Kenneth F. Kubiak
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Patent number: 5858911Abstract: Disclosed is a rigid fine-celled foam composition and a method of producing it. The foam composition is nontoxic, environmentally friendly, has improved absorption/adsorption and retention of liquids, is not as hard as prior art foams, does not include polymerization by-products detrimental to flower and plant life, and is a foamed mixture of a caustic silicate solution derived from the caustic digestion of rice hull ash having diffused activated carbon particles from thermal pyrolysis of rice hulls rather than from commercial sodium silicate solutions. Valuable by-products of commodity grade are obtained including activated carbon and sodium fluoride.Type: GrantFiled: November 24, 1997Date of Patent: January 12, 1999Assignee: Agritec, Inc.Inventors: Clyde W. Wellen, Douglas K. Stephens, Greg R. Wellen
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Patent number: 5714000Abstract: Disclosed is a rigid fine-celled foam composition and a method of producing it. The foam composition is nontoxic, environmentally friendly, has improved absorption/adsorption and retention of liquids, is not as hard as prior art foams, does not include polymerization by-products detrimental to flower and plant life, and is a foamed mixture of a caustic silicate solution derived from the caustic digestion of rice hull ash having diffused activated carbon particles from thermal pyrolysis of rice hulls rather than from commercial sodium silicate solutions. Valuable by-products of commodity grade are obtained including activated carbon and sodium fluoride.Type: GrantFiled: July 10, 1996Date of Patent: February 3, 1998Assignee: Agritec, Inc.Inventors: Clyde W. Wellen, Douglas K. Stephens, Greg R. Wellen