Patents by Inventor CODEXIS, INC.

CODEXIS, INC. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED KETOREDUCTASE POLYPEPTIDES
    Publication number: 20130210098
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe.
    Type: Application
    Filed: February 11, 2013
    Publication date: August 15, 2013
    Applicant: CODEXIS, INC.
    Inventor: CODEXIS, INC.
  • KETOREDUCTASES AND USES THEREOF
    Publication number: 20130196408
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: March 11, 2013
    Publication date: August 1, 2013
    Applicant: CODEXIS, INC.
    Inventor: CODEXIS, INC.
  • KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES
    Publication number: 20130078692
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: November 20, 2012
    Publication date: March 28, 2013
    Applicant: CODEXIS, INC.
    Inventor: CODEXIS, INC.