Abstract: A capsule device (100) suitable for insertion or ingestion into a lumen, such as a gastrointestinal lumen, of a subject.

Abstract: The swallowable capsule device (10) comprises a capsule housing (12), a drug outlet (14) arranged relative to the capsule housing (12), a drug reservoir (16) configured to accommodate a drug substance (23) in use, and a needleless jet injector assembly. The needleless jet injector assembly includes a jet injector (22) and an actuator. The jet injector (22) has a plurality of jet nozzles (24) and the actuator is configured to actuate under predetermined conditions to expel the drug substance (23) in use from the drug reservoir out through the drug outlet (14) via the jet nozzles (24) to form a jet stream. Each jet nozzle (24) is configured to expel a separate collimated jet stream (28) having a peak jetting power of 1 W or below, and the plurality of jet nozzles (24) are arranged in a cluster so that the separate collimated jet streams (24) in combination form a contiguous jet stream (20) that is configured to be expelled towards the lumen wall.

Abstract: A capsule device (10) suitable for swallowing into a lumen of an intestinal tract of a patient comprises a housing section (12), a delivery outlet (20) for jet injection by a delivery assembly (22), an expansion assembly (26) and an expansion control mechanism (30). The expansion section (28) is arranged laterally opposite to and physically separated from the delivery outlet (20). An expansion section (28) of the expansion assembly (26) is laterally expandable from a non-expanded configuration to an expanded configuration for positioning the delivery outlet (20) against the lumen wall (14). The expansion control mechanism (30) is configured to activate the expansion assembly (26) under a predetermined condition to permit change of the expansion section (28) from the non-expanded configuration to the expanded configuration.