Abstract: Described embodiments are directed toward prosthetic valves and systems and methods of making prosthetic valves. For example, a prosthetic valve can comprise a frame defining a generally tubular shape and comprising frame members defining an open pattern of apertures, where the open pattern of apertures includes a plurality of windows and a plurality of circumferentially extending rows of apertures. Each window has a first width, each aperture of the circumferentially extending rows of apertures has a second width, the first width being at least double the second width, and the widths defined in the circumferential direction. The prosthetic valve can further comprise a plurality of leaflets formed from a single sheet of material, where the plurality of leaflets extends from the frame.

Abstract: An improved medical device reduces the loss of longitudinal length during expansion of a stent-graft from a compressed state to an expanded state. For example, the stent-graft is placed over a cover that provides resistance to expansion of the balloon during inflation, which reduces longitudinal compressing forces exerted on the stent-graft.

Abstract: Described embodiments are directed toward prosthetic valves having leaflets of particular shapes that control bending character. In accordance with an embodiment, a prosthetic valve has a plurality of leaflets. Each leaflet includes a central region and two side regions on opposite sides of the central region. The central region is defined by a shape of an isosceles triangle defined by two central region sides, the leaflet base and the leaflet free edge, wherein the two central region sides converge from the leaflet base. Each of the two side regions has a shape of a triangle and each is defined by one of the central region sides, one of the leaflet sides, and the leaflet free edge.

Abstract: Valves are disclosed that include an outer frame forming an annular structure, an inner frame nested coaxially within an inner diameter of the outer frame, the inner frame including a plurality of posts on an outflow end thereof, wherein a majority of an axial dimension of the inner frame is disposed between axial inflow and outflow ends of the outer frame, and a plurality of leaflets supported by the inner frame. Valves are disclosed that include an outer frame having an annular form, an inner frame that is coaxial with and nested within the outer frame, and a plurality of leaflets supported by the inner frame, wherein leaflet commissure posts associated with the plurality of leaflets are not held in fixed engagement with the outer frame, such that the leaflet commissure posts are operable to flex under loading during valve operation.

Abstract: Described embodiments are directed toward prosthetic valves and systems and methods of making prosthetic valves. In accordance with an embodiment, a prosthetic valve comprises and leaflet frame, and outer frame and a film. The leaflet frame has a generally tubular shape defining a plurality of leaflet windows. The outer frame has a generally tubular shape. The leaflet frame is coaxially disposed at least partially within the outer frame. The leaflet frame and outer frame is coupled at least in part by a contiguous portion of the film. At least a portion of the contiguous portion of the film is contained between and coupling the leaflet frame and outer frame operable to prevent relative movement and contact therebetween. The film defines a leaflet extending from each of the leaflet windows.

Abstract: An occlusive device includes a covering component configured to modulate passage of blood or thrombus therethrough, and an occlusion frame that includes a plurality of elongate occlusion frame members. The elongate occlusion frame members are arranged to form a generally disc-shaped member. The occlusion frame is at least partially covered by the covering component. The device further includes an anchor frame that includes a plurality of elongate anchor frame members. The device further includes a first hub component from which the elongate frame members extend, and a second hub component from which the elongate frame members extend.

Abstract: A prosthetic implant transitionable between a delivery configuration and a deployed configuration in-situ, the prosthetic implant includes a first frame subcomponent and a second frame subcomponent. The first frame subcomponent and the second frame subcomponent each include a proximal end and a distal end. The second frame subcomponent is coupled to the first frame subcomponent. When situated in the delivery configuration, the first frame subcomponent and the second frame subcomponent are longitudinally offset from one another. When transitioned to the deployed configuration in-situ, the first frame subcomponent is nested within an interior region defined by the second frame subcomponent. The prosthetic implant is configured to capture one or more of the native leaflets of a native valve when the first frame subcomponent and the second frame subcomponent are nested in-situ.

Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valves having a frame and a leaflet construct. Leaflet frame attachments for prosthetic valves include the leaflet construct being at least partially coupled to a frame outer side by a looped structure.

Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having synthetic leaflets that are configured to promote and encourage tissue ingrowth thereon and/or therein. The leaflets are coupled to a leaflet frame to form a prosthetic valve suitable for use in biological anatomy.

Abstract: Described embodiments are directed toward prosthetic valves having leaflets of particular shapes that control bending character. In accordance with an embodiment, a prosthetic valve has a plurality of leaflets. Each leaflet includes a central region and two side regions on opposite sides of the central region. The central region is defined by a shape of an isosceles triangle defined by two central region sides, the leaflet base and the leaflet free edge, wherein the two central region sides converge from the leaflet base. Each of the two side regions has a shape of a triangle and each is defined by one of the central region sides, one of the leaflet sides, and the leaflet free edge.

Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having a leaflet frame coaxially disposed within a body frame, as well as methods of making the valve devices.

Abstract: A prosthetic valve includes an outer frame defining an outer frame lumen, the outer frame including an inflow flange that flares radially outward, a medial portion having a straight wall frame segment, and an outflow end portion that tapers radially inward. The prosthetic valve can further include a leaflet support structure, one or more leaflets secured to the leaflet support structure, and a retention structure configured to hold the leaflet support structure in a fixed position relative to the outer frame when the leaflet structure is disposed at least partially within the outer frame lumen in a deployed configuration of the prosthetic valve.

Abstract: An implantable device is disclosed. The device includes a leaflet frame subcomponent and an anchor frame subcomponent that are configured to be delivered in a series configuration and subsequently nested or telescoped in-situ.

Abstract: A covering for a prosthetic valve comprises a first portion configured to couple to an outflow side of a prosthetic valve and a second portion configured to couple to an inflow side of the prosthetic valve. The first portion is annular in shape and has a first edge alternating between one or more first tips and one or more first valleys. The second portion is also annular in shape and has a second edge alternating between one or more second tips and one or more second valleys. The one or more second tips are configured to couple to the one or more first tips to at least partially cover posts of the prosthetic valve. The one or more second tips have a tapered form.

Abstract: An implantable device is disclosed. The device includes a two or three-piece frame assembly that is configured to be delivered in a series configuration and subsequently nested or telescoped in-situ.

Abstract: Prosthetic valves having a frame and at least one leaflet. The leaflet comprises means for allowing fluid that is behind the leaflet to pass through to the front of the leaflet when the leaflet is not in the closed position. The prosthetic valve includes a leaflet moveable between an open position that permits antegrade flow through the prosthetic valve and a closed position that prevents regurgitant flow through the prosthetic valve, the leaflet having an aperture or gap, or a separation of portions of the leaflet to allow a flow or exchange of fluid between a front and back of the leaflet, when the leaflet is not in the closed position.

Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valves having a frame and a leaflet construct. Leaflet frame attachments for prosthetic valves include the leaflet construct being at least partially coupled to a frame outer side by a looped structure.

Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having synthetic leaflets that are configured to promote and encourage tissue ingrowth thereon and/or therein. The leaflets are coupled to a leaflet frame to form a prosthetic valve suitable for use in biological anatomy.

Abstract: Described embodiments are directed toward centrally-opening leaflet prosthetic valve devices having a leaflet frame and a mechanically coupled leaflet. The described leaflet frames have projections that are configured to couple with a leaflet attachment region of a leaflet. Some embodiments include a leaflet retention feature that engages the leaflet frame projections and operates to secure the leaflet to the leaflet frame. Methods of making and using such prosthetic valve devices are also described.

Abstract: A method can comprise: positioning a prosthetic heart valve in a collapsed configuration at an implantation site. In some examples, the prosthetic heart valve can comprise: a multi-part frame having a body frame and a leaflet frame, and at least one leaflet coupled to the multi-part frame. In some examples, the prosthetic heart valve can be expandable between the collapsed configuration and an expanded configuration. The method can further comprise expanding the prosthetic heart valve to the expanded configuration at the implantation site, transitioning the multi-part frame of the prosthetic heart valve from a non-everted configuration to an everted configuration, and securing the prosthetic heart valve at the implantation site.