Abstract: An image processing apparatus for computing a quantitative imaging biomarker (QIB) of disease severity from variations in texture-based features in a tomographic image, the apparatus including a first preprocessing module for normalizing the intensities in the tomographic image; a second identification module for identifying at least one organ of interest in the tomographic image; a third ROI selection module for identifying and selecting a plurality of target ROIs and reference ROIs representative respectively of abnormal and normal pathology in the organ(s) of interest; a fourth ROI assessment module for extracting a plurality of texture-based feature signatures from the target ROIs and the reference ROIs, wherein the feature signatures are generated from distributions of statistical attributes extracted from each ROI; a fifth biomarker assessment module for computing the distance between the target ROI signatures and the reference ROI signatures, wherein the biomarker of disease severity is a function of t

Abstract: The invention concerns a device for measuring the position of the fixing point (P') of an eye on a video screen (19) comprising: a mobile support (10) positioned close to the eye and on which first illumination means (12) and a video camera (11) are fixed so as to embody images of the eye, and a fixed support (17) distant from the eye and on which the video screen orientated opposite the eye and a plurality of luminous sources illuminating the eye in alternative with the first illumination means are positioned and disposed around the video screen so as to create on the eye corneal reflections and means (20) for treating the images obtained from the eye.