Patents by Inventor Colin A. Hill

Colin A. Hill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220184174
    Abstract: An isolated lantibiotic is provided comprising amino acid sequence SEQ. ID No. 2 and at least one of amino acid sequences SEQ. ID No. 4 and SEQ. ID. No 6. Also provided is use of the lantibiotic in the treatment or prevention of infection by Group B Streptococcus or Corynebacterium xerosis. The invention further relates to isolated S. hominis strains and use of same in producing the lantibiotic. A vector is provided comprising nucleotides sequences for producing the lantibiotic.
    Type: Application
    Filed: March 4, 2020
    Publication date: June 16, 2022
    Inventors: Reynolds Paul ROSS, Catherine Stanton, Colin Hill, Anthony Ryan, Julie O'Sullivan, Claire Watkins
  • Patent number: 11086717
    Abstract: Method and apparatus for managing data in a non-volatile memory (NVM) of a storage device, such as a solid-state drive (SSD). In some embodiments, flash memory cells are arranged along word lines to which read voltages are applied to sense programmed states of the memory cells, with the flash memory cells along each word line being configured to concurrently store multiple pages of data. An encoder circuit is configured to apply error correction encoding to input data to form code words having user data bits and code bits, where an integral number of the code words are written to each page. A reference voltage calibration circuit is configured to randomly select a single selected code word from each page and to use the code bits from the single selected code word to generate a set of calibrated read voltages for the associated page.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: August 10, 2021
    Assignee: Seagate Technology LLC
    Inventors: Mehmet Emin Aklik, Antoine Khoueir, Ara Patapoutian, Colin Hill, Kurt Walter Getreuer, Darshana H. Mehta
  • Publication number: 20210220411
    Abstract: Disclosed herein are compositions and methods for preventing, ameliorating, or treating Clostridium difficile infections and/or reducing the severity of one or more risk factors, signs, or symptoms associated with C. difficile infections. In particular, the technology of the present disclosure relates to methods for administering an effective amount of a composition comprising strains of Bacillus amyloliquefaciens bacteria identified as ART24, ART4, and ART 12, to a subject suffering from or at risk for C. difficile infections.
    Type: Application
    Filed: June 6, 2019
    Publication date: July 22, 2021
    Inventors: Ronald Farquhar, Christopher K. Murphy, Colin Hill, Paul Ross, Mary Rea, Michelle O'Donnell, Brian Healy, Laurent Chesnel
  • Publication number: 20210128657
    Abstract: The invention relates to the extraction of pharmaceutically active components from plant materials, and more particularly to the preparation of a botanical drug substance (BDS) for incorporation in to a medicament. It also relates to a BDS of given purity, for use in pharmaceutical formulations. In particular it relates to BDS comprising cannabinoids obtained by extraction from cannabis.
    Type: Application
    Filed: June 18, 2020
    Publication date: May 6, 2021
    Applicant: GW Pharma Limited
    Inventors: BRIAN ANTHONY WHITTLE, Colin A. Hill, Ian R. Flockhart, David Victor Downs, Peter Gibson, Gary William Wheatley
  • Publication number: 20210133025
    Abstract: Method and apparatus for managing data in a non-volatile memory (NVM) of a storage device, such as a solid-state drive (SSD). In some embodiments, flash memory cells are arranged along word lines to which read voltages are applied to sense programmed states of the memory cells, with the flash memory cells along each word line being configured to concurrently store multiple pages of data. An encoder circuit is configured to apply error correction encoding to input data to form code words having user data bits and code bits, where an integral number of the code words are written to each page. A reference voltage calibration circuit is configured to randomly select a single selected code word from each page and to use the code bits from the single selected code word to generate a set of calibrated read voltages for the associated page.
    Type: Application
    Filed: October 31, 2019
    Publication date: May 6, 2021
    Inventors: Mehmet Emin Aklik, Antoine Khoueir, Ara Patapoutian, Colin Hill, Kurt Walter Getreuer, Darshana H. Mehta
  • Publication number: 20200405787
    Abstract: The present invention provides a pharmaceutical composition comprising dead cells of Lactobacillus strains useful for the protection of subjects against the development of conditions with behavioral, psychological and/or physical components caused or exacerbated by stress or anxiety, and/or useful in treating existing conditions with behavioral, psychological and/or physical components caused or exacerbated by stress or anxiety. Examples of specific conditions include stress, anxiety, depression, mood disturbances, sociability disorders, irritable bowel syndrome, autism, autism spectrum disorder, post-traumatic stress disorder, chronic stress and a range of other stress-related diseases.
    Type: Application
    Filed: March 22, 2019
    Publication date: December 31, 2020
    Inventors: Colin HILL, Ted DINAN, Alicja WARDA, Stephen PERRETT
  • Publication number: 20200306328
    Abstract: The invention relates to the extraction of pharmaceutically active components from plant materials, and more particularly to the preparation of a botanical drug substance (BDS) for incorporation in to a medicament. It also relates to a BDS of given purity, for use in pharmaceutical formulations. In particular it relates to BDS comprising cannabinoids obtained by extraction from cannabis.
    Type: Application
    Filed: October 30, 2019
    Publication date: October 1, 2020
    Applicant: GW Pharma Limited
    Inventors: Brian Anthony Whittle, Colin A. Hill, Ian R. Flockhart, David Victor Downs, Peter Gibson, Gary William Wheatley
  • Publication number: 20190119158
    Abstract: An improved process for the preparation of aggregates for use with mixtures of various carbonatable substances, in particular mixtures comprising pulverised fuel ash and/or steel slag. The mixtures also comprise a carbonatable binder. The process comprises the steps of a. blending a combination of two carbonatable wastes, b. mixing the blended carbonatable waste with a carbonatable binder, c. mixing the blended carbonatable waste and binder with water, and d. carbonating the damp blended carbonatable waste in the presence of carbon dioxide.
    Type: Application
    Filed: May 11, 2017
    Publication date: April 25, 2019
    Inventors: Colin HILLS, Paula CAREY
  • Publication number: 20170290869
    Abstract: The invention relates to the extraction of pharmaceutically active components from plant materials, and more particularly to the preparation of a botanical drug substance (BDS) for incorporation in to a medicament. It also relates to a BDS of given purity, for use in pharmaceutical formulations. In particular it relates to BDS comprising cannabinoids obtained by extraction from cannabis.
    Type: Application
    Filed: March 23, 2017
    Publication date: October 12, 2017
    Applicant: GW Pharma Limited
    Inventors: Brian Anthony Whittle, Colin A. Hill, Ian R. Flockhart, David Victor Downs, Peter Gibson, Gary William Wheatley
  • Publication number: 20170253638
    Abstract: An antimicrobial peptide having potent antibacterial activity against Listeria monocytogenes and Staphylococcus aureus is described. Also described is an isolated Lactobacillus salivarius DPC6502 strain as deposited with the National Collection of Industrial and Marine Bacteria under the Accession No. NCIMB 41840, and variants thereof, wherein the isolated bacteria and variants thereof express an antimicrobial peptide of the invention.
    Type: Application
    Filed: April 3, 2017
    Publication date: September 7, 2017
    Applicants: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK, AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC)
    Inventors: Paul ROSS, Eileen O'SHEA, Colin HILL
  • Patent number: 9597362
    Abstract: The disclosure relates to the live cultures of probiotic bacteria to treat infectious diseases in humans and animals. Food-grade or non-pathogenic cultures are used to treat localised infections.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: March 21, 2017
    Assignees: TEAGASC, THE AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY, UNIVERSITY COLLEGE, CORK-NATIONAL UNIVERSITY OF IRELAND
    Inventors: Paul Ross, Colin Hill, William Meaney
  • Publication number: 20160120963
    Abstract: A non-therapeutic method of reducing weight gain, serum cholesterol levels, or liver triglyceride levels, in a non-obese mammal, comprises the step of administering to the gut of a mammal an effective amount of a bacteria expressing a BSH1 enzyme of SEQUENCE ID NO: 1, or a functional variant thereof; a BSH1 enzyme of SEQUENCE ID NO: 1, or a functional variant thereof for use as a medicament; isolated bacterial strains expressing functional variants of BSH1.
    Type: Application
    Filed: June 12, 2014
    Publication date: May 5, 2016
    Applicant: University College Cork, National University of Ireland
    Inventors: Susan Joyce, Cormac Gahan, Colin Hill
  • Patent number: 8987194
    Abstract: A Nisin derivative or variant, comprising an amino acid substitution at amino acid position 29 in the amino acid sequence. The Nisin derivative exhibits enhanced antimicrobial activity when compared to wild type Nisin. The Nisin derivative has an application as a natural food additive and as a therapeutic agent.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: March 24, 2015
    Assignees: University College Cork-National University of Ireland, Cork, Agriculture and Food Development Authority
    Inventors: Colin Hill, Paul Cotter, Paul R. Ross, Desmond Field
  • Patent number: 8987193
    Abstract: The present invention relates to a nisin derivative comprising amino acid substitutions in the peptide sequence encoding the hinge region of the protein, wherein the derivative exhibits an increased anti-microbial activity.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: March 24, 2015
    Assignee: University College Cork—National University of Ireland, Cork
    Inventors: Paul Cotter, Colin Hill, Desmond Field
  • Patent number: 8852917
    Abstract: The present invention relates to a new bacteriocin, to microbial strains which can produce it and to uses of the bacteriocin and the strains. The bacteriocin is effective against Clostridium difficile and Listeria monocytogenes amongst other organisms.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: October 7, 2014
    Assignees: University College Cork, TEAGASC, The Agriculture and Food Development Authority
    Inventors: Colin Hill, Mary Rea, Paul Ross
  • Publication number: 20140286904
    Abstract: An antimicrobial peptide having potent antibacterial activity against Listeria monocytogenes and Staphylococcus aureus is described. Also described is an isolated Lactobacillus salivarius DPC6502 strain as deposited with the National Collection of Industrial and Marine Bacteria under the Accession No. NCIMB 41840, and variants thereof, wherein the isolated bacteria and variants thereof express an antimicrobial peptide of the invention.
    Type: Application
    Filed: July 27, 2012
    Publication date: September 25, 2014
    Applicants: AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC), UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventors: Paul Ross, Eileen O'Shea, Colin Hill
  • Patent number: 8603461
    Abstract: The invention provides a probiotic composition to alleviate Salmonella infection in farm animals. The composition may comprise at least one of Lactobacillus murinus, Lactobacillus pentosus, Lactobacillus salivarius sub-species salivarius, and Pediococcus pentosaceus. The composition maybe formulated as an animal feedstuff, or as a pharmaceutical composition.
    Type: Grant
    Filed: April 6, 2006
    Date of Patent: December 10, 2013
    Assignees: TEAGASC—The Agriculture and Food Development Authority, University College Cork
    Inventors: Catherine Stanton, Colin Hill, Ger Fitzgerald, Paul Ross
  • Patent number: 8563292
    Abstract: Crude solid vanillin-containing material is precipitated from a solution obtained by biotransformation, and purified by a process comprising contacting it with a purification fluid selected from (a) a liquefied gas whose pressure exceeds its critical pressure and whose temperature is below its critical temperature; (b) a supercritical fluid; (c) a gas. The fluid is preferably liquid carbon dioxide. The temperature is maintained below 25° . The product may be further purified by treatment with CO2 in a fluid bed drier. The crude material is preferably one precipitated from a solution resulting from biotransformation of ferulic acid. A new strain of Amycolatopsis capable of generating high concentrations of vanillin with minimal odoriferous by-products (e.g. guaiacol) is also disclosed.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: October 22, 2013
    Assignee: SAF-ISIS
    Inventors: Steve Heald, Steve Myers, Tim Walford, Keith Robbins, Colin Hill
  • Publication number: 20130005647
    Abstract: A Nisin derivative or variant, comprising an amino acid substitution at amino acid position 29 in the amino acid sequence. The Nisin derivative exhibits enhanced antimicrobial activity when compared to wild type Nisin. The Nisin derivative has an application as a natural food additive and as a therapeutic agent.
    Type: Application
    Filed: December 22, 2010
    Publication date: January 3, 2013
    Applicants: University College Cork, National University of Ireland, Teagasc, The Agriculture and Food Development Authority
    Inventors: Colin Hill, Paul Cotter, Paul R. Ross, Desmond Field
  • Publication number: 20120177608
    Abstract: An isolated bacteriophage MR299-2 or NH-4 deposited under NCIMB Deposit Accession Nos. 41729 and 41730, respectively, is described. The phages have lytic activity against P. aeruginosa strains, including mucoid and CF clinical isolate strains. Variant hages are also described, wherein said variants retain the phenotypic characteristics of said phage and wherein said phage and variants thereof have lytic activity against P. aeruginosa strains.
    Type: Application
    Filed: December 20, 2011
    Publication date: July 12, 2012
    Applicants: AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC), UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventors: Paul Ross, Debebe Alemayehu, Colin Hill, James Gerard Martin