Patents by Inventor Colin A. Leach

Colin A. Leach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100179109
    Abstract: Disclosed are compounds of Formula (I) wherein the R, R1, R2, R3, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
    Type: Application
    Filed: April 4, 2008
    Publication date: July 15, 2010
    Inventors: Jonh J. Baldwin, Salvacion Cacatian, David Claremon, Lawrence W. Dillard, Patrick T. Flaherty, Bahman Ghavimi-Alagha, Damiano Ghirlanda, Alexey V. Ishchenko, Lara S. Kallander, Brian Lawhorn, Colin A. Leach, Qing Lu, Gerard McGeehan, Jaclyn R. Patterson, Robert D. Simpson, Suresh B. Singh, Patrick Stoy, Lamont R. Terrell, Colin Tice, Zhenrong Xu, Jing Yuan, Catherine C. K. Yuan, Jing Zhang, Wei Zhao
  • Publication number: 20090275581
    Abstract: Disclosed are compounds according to Formula I: wherein the variables are defined herein. Such compounds are can bind aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described herein are methods of antagonizing aspartic protease inhibitors in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound according to Formula I.
    Type: Application
    Filed: April 5, 2007
    Publication date: November 5, 2009
    Inventors: John J. Baldwin, David A. Claremon, Colin M. Tice, Salvacion Cacatian, Lawrence W. Dillard, Alexey V. Ishchenko, Jing Yuan, Zhenrong Xu, Gerard McGeehan, Wei Zhao, Robert D. Simpson, Suresh B. Singh, Patrick T. Flaherty, Lara S. Kallander, Colin A. Leach, Brian Lawhorn, Qing Lu, Lamont R. Terrell, Bahman Ghavini-Alagha, Jing Zhang, Damiano Ghirlanda, Xiaoping Hou, Simon Semus
  • Patent number: 5432182
    Abstract: Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention are the salts of strong acids of 3-butyryl-4-(2-methylphenylamino)-8-(hydroxymethyl)quinoline.
    Type: Grant
    Filed: January 29, 1992
    Date of Patent: July 11, 1995
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Robert J. Ife, Colin A. Leach
  • Patent number: 5420135
    Abstract: Substituted quinoline derivatives are described as inhibitors bone resorption with in particular, the compound 1-(2-methylphenyl)imidazo[4,5-c]quinoline hydrochloride.
    Type: Grant
    Filed: December 10, 1990
    Date of Patent: May 30, 1995
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach, David J. Keeling
  • Patent number: 5409943
    Abstract: The present invention relates to N-pyridylamidine and N-pyridylguanidine derivatives of general formula (I) in which: Ar.sup.1 is an optionally substituted phenyl ring; Ar.sup.2 is an optionally substituted phenyl ring; R.sup.1 is hydrogen or C.sub.1-4 alkyl; R.sup.2 is hydrogen or C.sub.1-4 alkyl; R.sup.3 is hydrogen or C.sub.1-4 alkyl; R.sup.4 is hydrogen, halogen, C.sub.1-6 alkyl or C.sub.1-6 alkoxy; X is CH.sub.2 or NR.sup.5, and R.sup.5 is hydrogen or C.sub.1-4 alkyl, and the salts thereof, and their use in therapy as gastric acid secretion inhibitors.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: April 25, 1995
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Robert J. Ife, Colin A. Leach, Dashyant Dhanak
  • Patent number: 5280026
    Abstract: Thienopyrimidine compounds are disclosed as inhibitors of the H.sup.+ K.sup.+ ATPase enzyme useful in the treatment of gastric acid secretion. A compound of the invention is 2-(2-methylphenylamino)-4-(N-methylphenylamino)thieno[3,2-d]pyrimidine.
    Type: Grant
    Filed: November 24, 1992
    Date of Patent: January 18, 1994
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • Patent number: 5200417
    Abstract: Isoquinoline compounds, compositions containing them and their use in the inhibition of gastric acid secretion in mammals. A compound of the invention is 1-[(2-Methoxyphenylmethyl)amino]isoquinoline hydrochloride.
    Type: Grant
    Filed: April 4, 1990
    Date of Patent: April 6, 1993
    Assignee: Smithkline Beecham Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • Patent number: 5143920
    Abstract: Substituted 4-aminoquinazoline derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkoxy C.sub.1-6 alkyl,C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl C.sub.1-6 alkyl, phenyl C.sub.1-6 alkyl, the phenyl group being optionally substituted;R.sup.2 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, C.sub.1-6 alkanoyl or trifuromethyl;m is 1 to 3;R.sup.3 is hydrogen, C.sub.1-6 alkyl, phenyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, C.sub.1-6 alkanoyl, amino, C.sub.1-6 alkylamino, ci-C.sub.1-6 alkylamino, halogen, trifluoromethyl or cyano;n is 1 or 2; andR.sup.4 is hydrogen; or a salt thereof are useful as inhibitors of gastric acid secretion.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: September 1, 1992
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Patent number: 5089498
    Abstract: Substituted 4-aminiquinazoline derivatives of the formula: ##STR1## in which R.sup.1 hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkylC.sub.1-6 alkyl, phenylC.sub.1-6 alkyl, the phenyl group being optionally substituted;R.sup.2 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C.sub.1-6 alkanoyl or trifluromethyl;m is 1 to 3;p is 0 to 4;R.sup.3 is COR.sup.4 ;R.sup.4 is hydroxy, C.sub.1-6 alkoxy, or NR.sup.5 R.sup.6 ;R.sup.5 and R.sup.6 are each hydrogen or C.sub.1-6 alkyl or together with the nitrogen atom to which they are attached form a heterocyclic ring; andR.sup.7 is hydrogen, C.sub.1-6 alkoxy or C.sub.1-6 alkyl;or a salt thereof.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: February 18, 1992
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Patent number: 5089504
    Abstract: Substituted 4-aminoquinazoline derivatives of the formula: ##STR1## in which R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkylC.sub.1-6 alkyl, phenylC.sub.1-6 alkyl, the phenyl group being optionally substituted;R.sup.2 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C.sub.1-6 alkanoyl or trifluoromethyl;m is 1 to 3;p is 0 to 4;R.sup.3 is COR.sup.4 ;R.sup.4 is hydroxy, C.sub.1-6 alkoxy, or NR.sup.5 R.sup.6 ;R.sup.5 and R.sup.6 are each hydrogen or C.sub.1-6 alkyl or together with the nitrogen atom to which they are attached form a heterocyclic ring; andR.sup.7 is hydrogen, C.sub.1-6 alkoxy or C.sub.1-6 alkyl;or a salt thereof.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: February 18, 1992
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Patent number: 5082841
    Abstract: Aminoquinoline derivatives are described as inhibitors of the H.sup.+ K.sup.+ ATPase enzyme useful in the treatment of gastric acidity. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-(3-dimethylaminopropoxy)quinoline.
    Type: Grant
    Filed: August 7, 1990
    Date of Patent: January 21, 1992
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • Patent number: 5082848
    Abstract: Substituted 4-aminoquinoline derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxyC.sub.1-6 alkyl; C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-6 alkyl, phenyl C.sub.1-6 alkyl, the phenyl groups being optionally substituted;R.sup.2 is hydroxy C.sub.1-6 alkyl, C.sub.1-6 alkoxyC.sub.1-6 alkyl or two adjacent groups R.sup.2 together form a C.sub.1-4 alkylenedioxy group;R.sup.3 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, C1-6alkanoyl, or trifluromethyl;R.sup.4 is hydrogen, C.sub.1-6 alkyl, phenyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, C.sub.1-6 alkanoyl, amino, C.sub.1-6 alkylamino, di- C.sub.1-6 alkyl amino, halogen, or trifluromethyl;n is 1 or 2;q is 0 to 4;m is 1, 2, or 3; andp is 1, 2, 3, or 4 provided that m+p is not greater than 5;or a salt thereof are useful as inhibitors of gastric acid secretion.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: January 21, 1992
    Assignee: Smith Kline & French Laboratories, Ltd.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Patent number: 5064833
    Abstract: 2,4-diaminoquinazoline compounds are inhibitors of the H.sup.+ K.sup.+ ATPase enzyme and useful for the treatment of diseases of the stomach based on excessive gastric acid secretion. A compound of the invention is 2-[2-methyl-4-fluorophenyl)amino]-4-(N-methylphenylamino)quinazoline.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: November 12, 1991
    Assignee: Smithkline Beecham Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach, David J. Keeling
  • Patent number: 5051508
    Abstract: 1,4-Substituted 2,3-dihydropyrrolo[3,2-c]quinolines which are inhibitors of H.sup.+ K.sup.+ ATPase activity and useful as inhibitors of gastric acid secretion. A compound of the invention is 1-(2-methylphenyl)-4-amino-6-methyl-2,3-dihydropyrrolo[3,2-c]quinoline.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: September 24, 1991
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • Patent number: 5049567
    Abstract: Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention is ethyl 8-methoxy-4-(4-methyl-3-thinenylamino)quinoline-3-carboxylate.
    Type: Grant
    Filed: January 9, 1991
    Date of Patent: September 17, 1991
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Patent number: 5006535
    Abstract: Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention is ethyl 8-methoxy-4-(4-methyl-3-thienyl-amino)quinoline-3-carboxylate.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: April 9, 1991
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Patent number: 4935431
    Abstract: Substituted 4-aminothienopyridine derivatives which are inhibitors of gastric acid secretion. A compound of the invention is 6-butyryl-7-(2-isopropylphenylamino)-thieno[3,2-b]pyridine.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: June 19, 1990
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Patent number: 4806550
    Abstract: This invention relates to novel substituted 4-aminoquinoline derivatives which are inhibitors of gastric acid secretion in mammals. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline.
    Type: Grant
    Filed: May 12, 1988
    Date of Patent: February 21, 1989
    Assignee: SmithKline & French Laboratories Limited
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Patent number: 4806549
    Abstract: This invention relates to novel substituted 4-aminoquinoline derivatives which are inhibitors of gastric acid secretion in mammals. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: February 21, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach